Results 101 to 110 of about 12,878,813 (328)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Earlier Buddhist Theories of Free Will: Compatibilism [PDF]

open access: yes, 2010
A critical review of the first wave of publications on Buddhism and free will between the 1960s and ...
Repetti, Rick
core   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

Free will as private determinism [PDF]

open access: yes
This article suggests that our sense of free will is formed when others react to our behavior with surprise, even though our private knowledge tells us our behavior was determined by our preferences.
Markovitch, J. S.
core  

Free Will, Moral Responsibility, and Scientific Epiphenomenalism

open access: yesFrontiers in Psychology, 2018
This article addresses two influential lines of argument for what might be termed “scientific epiphenomenalism” about conscious intentions – the thesis that neither conscious intentions nor their physical correlates are among the causes of bodily motions
Alfred R. Mele
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Free Will: Who Can Know [PDF]

open access: yes
I have inquired as to what sort of knowledge humans need to make justifiable claims regarding free will. I defended the thesis that humans do not have the sort of knowledge which would allow them to make such claims.
Zafer, Kılıç
core  

Free will, robots, and the axiom of choice [PDF]

open access: yes, 2012
There are quite a number of similarities between the moral concept of choice and the mathematical axiom of choice. These similarities shed light on how to adapt law to solve cases that arise with the increasing “autonomy” of ...
Schuhr, Jan C.
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy