Results 131 to 140 of about 13,970,787 (337)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Invariant Theory for the free left-regular band and a q-analogue [PDF]

open access: green, 2022
Sarah Brauner   +2 more
openalex   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tumor‐Targeted Multimodal Optical Imaging with Versatile Cadmium‐Free Quantum Dots

open access: green, 2015
Xiangyou Liu   +13 more
openalex   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

FREE WILL HAS A NEURAL SUBSTRATE: CRITIQUE OF JOSEPH F. RYCHLAK'S DISCOVERING FREE WILL AND PERSONAL RESPONSIBILITY

open access: yesZygon, 1983
. Ably marshalling ideas from theology, philosophy, and neurology, personality theorist Joseph F. Rychlak criticizes mechanistic psychologists' neglect of will and responsibility; these human qualities involve dialectically considering alternatives.
doaj   +2 more sources

Upset ratios in laser-based free form heading

open access: diamond, 2010
Andreas Stephen, Frank Vollertsen
openalex   +1 more source

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