Results 101 to 110 of about 6,492 (292)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2022 We define a new integer invariant of a finite graph G, the freeness index, that measures the extent to which G can be embedded in the 3-sphere so that it and its subgraphs have ``simple" complements, i.e., complements which are homeomorphic to a connect ...
Thompson, Abigail
core
An Ideal Criterion for Torsion Freeness [PDF]
Proceedings of the American Mathematical Society, 1972 Auslander and Bridger have shown that, under conditions somewhat weaker than finite projective dimension, the “torsion freeness” properties of a module M (e.g. being reflexive, being the k th syzygy of another module) are determined by certain ...
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Tensor product construction of 2-freeness [PDF]
, 1998 From a sequence of m-fold tensor product constructions that give a hierarchy of freeness indexed by natural numbers m we examine in detail the first non-trivial case corresponding to m=2 which we call 2-freeness. We show that in this case the constructed
Lenczewski, R.
core
BioResources, 2010 Malaysian cultivated kenaf has been identified as a suitable raw material for linerboard production. This study examines the soda-antraquinone (soda-AQ) pulp of kenaf fibers versus old corrugated container (OCC) and unbleached softwood kraft pulps as the
Ahmad Azizi Mossello +6 more
doaj
DT-CP: A Double-TTPs-Based Contract-Signing Protocol With Lower Computational Cost
IEEE Access, 2019 This paper characterizes a contract signing protocol with high efficiency in Internet of Things. Recent studies show that existing contract-signing protocols can achieve abuse-freeness and resist inference attack, but cannot meet the high-efficiency and ...
Guangquan Xu +6 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source