Results 81 to 90 of about 4,608 (301)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A practical application of sharing and freeness inference
, 1992 is not ...
Hermenegildo, Manuel V. +1 more
core
On (non-) freeness of some tridendriform algebras [PDF]
, 2016 International audienceWe present some results on the freeness or non freeness of some tridendriform algebras. In particular, we give a combinatorial proof of the freeness of WQSym, an algebra based on packed words, result already known with an algebraic ...
Vong, Vincent
core
Acting Semicircular Elements Induced by Orthogonal Projections on Von-Neumann-Algebras
Mathematics, 2017 In this paper, we construct a free semicircular family induced by Z -many mutually-orthogonal projections, and construct Banach ∗-probability spaces ...
Ilwoo Cho
doaj +1 more source
Union-Freeness, Deterministic Union-Freeness and Union-Complexity
, 2019 Union-free expressions are regular expressions without using the union operation. Consequently, union-free languages are described by regular expressions using only concatenation and Kleene star. The language class is also characterised by a special class of finite automata: 1CFPAs have exactly one cycle-free accepting path from each of their states ...
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Heavy hyperplanes in multiarrangements and their freeness
, 2018 Abe T, Kühne L. Heavy hyperplanes in multiarrangements and their freeness. Journal of Algebraic Combinatorics. 2018;48(4):581-606.Only few categories of free arrangements are known in which Terao's conjecture holds.
Kühne, Lukas ; https://orcid.org/ +1 more
core +1 more source
Smooth Counterexamples to Frame Bundle Freeness
Mathematics, 2019 We provide counterexamples to P. Olver’s freeness conjecture for C ∞ actions. In fact, we show that a counterexample exists for any connected real Lie group with noncompact center, as well as for the additive group of the integers.
Scot Adams
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source