Results 111 to 120 of about 25,607 (285)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

DT-CP: A Double-TTPs-Based Contract-Signing Protocol With Lower Computational Cost

open access: yesIEEE Access, 2019
This paper characterizes a contract signing protocol with high efficiency in Internet of Things. Recent studies show that existing contract-signing protocols can achieve abuse-freeness and resist inference attack, but cannot meet the high-efficiency and ...
Guangquan Xu   +6 more
doaj   +1 more source

Fair Division of Indivisible Items [PDF]

open access: yes
This paper analyzes criteria of fair division of a set of indivisible items among people whose revealed preferences are limited to rankings of the items and for whom no side payments are allowed.
Brams, S. J.   +2 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Faster and Simpler Distributed Algorithms for Testing and Correcting Graph Properties in the CONGEST-Model

open access: yes, 2017
In this paper we present distributed testing algorithms of graph properties in the CONGEST-model [Censor-Hillel et al. 2016]. We present one-sided error testing algorithms in the general graph model. We first describe a general procedure for converting
Even, Guy, Levi, Reut, Medina, Moti
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Vines and MAT-labeled graphs

open access: yesForum of Mathematics, Sigma
The present paper explores a connection between two concepts arising from different fields of mathematics. The first concept, called vine, is a graphical model for dependent random variables.
Hung Manh Tran   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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