Results 111 to 120 of about 4,294,743 (304)
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Effective base point freeness [PDF]
Let \(X\) be a projective variety with ``good'' \(K_X\) and \(L\in\text{Pic}(X)\). It is very important to know when \(K_X+mL\) is base point free or very ample. Here the author uses a technique due to Ein and Lazarsfeld to extend Ein-Lazarsfeld's theorems to singular 3-folds and prove the following result: Theorem.
openaire +3 more sources
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
HYDROGEN PEROXIDE BLEACHING OF CMP PULP USING MAGNESIUM HYDROXIDE
Conventional bleaching of hardwood CMP pulp with magnesium hydroxide (Mg(OH)2) show significant benefits over bleaching with sodium hydroxide (NaOH) under various conditions.
Farhad Zeinaly +3 more
doaj
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
The groupoid attached to the action of PSL(2,Z) on the irrational reals by linear fractional transformations is free.
openaire +2 more sources
Inductive Freeness of Ziegler’s Canonical Multiderivations
Abstract Let $${{\mathscr {A}}}$$ A be a free hyperplane arrangement. In 1989, Ziegler showed that the restriction $${{\mathscr {A}}}''$$
Torsten Hoge, Gerhard Röhrle
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