Results 11 to 20 of about 1,816 (73)

cIMPACT‐NOW update 11: Proposal on adaptation of diagnostic criteria for IDH‐ and H3‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors

Brain Pathology, EarlyView.
Abstract The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.
Pieter Wesseling, David Capper, Guido Reifenberger, Chitra Sarkar, Cynthia Hawkins, Arie Perry, Bette Kleinschmidt‐DeMasters, Takashi Komori, Werner Paulus, Vani Santosh, Martin van den Bent, Michael Weller, Stefan M. Pfister, Uri Tabori, Dominique Figarella‐Branger, Brent A. Orr, David N. Louis   +16 more
wiley   +1 more source

Comparative Cytokine and Histology Studies on HPV and Other Viral Vaccinations: No Pathogenicity of HPV Vaccine Adjuvants

Cancer Science, EarlyView.
Anti‐HPV vaccine activists claimed that aluminum (Al) adjuvants in HPV vaccines could cause immune abnormalities, leading to neurological diseases. We evaluated the cytokine and histology profiles following administrations of HPV vaccines and other viral vaccines containing adjuvants.
Reona Shiro, Fumitaka Sato, Seiichi Omura, Ah‐Mee Park, Cong Thanh Nguyen, Ijaz Ahmad, Sandesh Rimal, Koji Kinoshita, Noriomi Matsumura, Ikuo Tsunoda   +9 more
wiley   +1 more source

Morpho‐Histo‐Cytological Evaluation of Oral Tissues in Burning Mouth Syndrome: A Systematic Review

Journal of Oral Rehabilitation, EarlyView.
This systematic review on Burning Mouth Syndrome (BMS) included 14 studies that examined histological changes. 12 studies used incisional biopsies and 2 used exfoliative cytology. Histology and molecular biology techniques were used to assess morphological, phenotypical and genomic changes in oral tissues, primarily from the tongue.
André Luís Porporatti, Ângela Graciela Deliga Schroder, Ashley Lebel, Nathan Moreau, Annabelle Réaux‐Le Goazigo, Ihsène Taïhi, Heike Rittner, Tara Renton, Yves Boucher   +8 more
wiley   +1 more source

The PREVENT‐AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT‐AD) is an investigator‐driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median ...
Sylvia Villeneuve, Judes Poirier, John C. S. Breitner, Jennifer Tremblay‐Mercier, Jordana Remz, Jean‐Michel Raoult, Yara Yakoub, Jonathan Gallego‐Rudolf, Ting Qiu, Alfonso Fajardo Valdez, Bery Mohammediyan, Mohammadali Javanray, Amelie Metz, Safa Sanami, Valentin Ourry, Alfie Wearn, Alexandre Pastor‐Bernier, Manon Edde, Julie Gonneaud, Cherie Strikwerda‐Brown, Christine L. Tardif, Claudine J. Gauthier, Maxime Descoteaux, Mahsa Dadar, Étienne Vachon‐Presseau, Andrée‐Ann Baril, Simon Ducharme, Maxime Montembeault, Maiya R. Geddes, Jean‐Paul Soucy, Natasha Rajah, Robert Laforce, Christian Bocti, Christos Davatzikos, Lune Bellec, Pedro Rosa‐Neto, Sylvain Baillet, Alan C. Evans, D. Louis Collins, M. Mallar Chakravarty, Kaj Blennow, Henrik Zetterberg, R. Nathan Spreng, Alexa Pichet Binette, the PREVENT‐AD Research Group   +44 more
wiley   +1 more source

Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract BACKGROUND The apolipoprotein E (APOE) gene includes the strongest protective (ε2) and risk (ε4) variants for sporadic Alzheimer's disease (AD), but underlying mechanisms remain unclear. We studied APOE genotype effects on the cerebrospinal fluid (CSF) proteome.
Eleonora M. Vromen, Senne B. Lageman, Johan Gobom, Rik van der Kant, Valerija Dobricic, Lars Bertram, Johannes Streffer, Simon Lovestone, Stephanie J. B. Vos, Mikel Tainta, Yvonne Freund‐Levi, Lutz Frölich, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Frans Verhey, Rik Vandenberghe, Jolien Schaeverbeke, Kaj Blennow, Sven J. van der Lee, Philip Scheltens, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Charlotte E. Teunissen, Henrik Zetterberg, Pieter Jelle Visser, Betty Tijms   +26 more
wiley   +1 more source

Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Most individuals with isolated rapid eye movement sleep behavior disorder (iRBD) develop dementia with Lewy bodies (DLB) or Parkinson's disease (PD). Brain biomarkers predicting specific phenoconversion trajectories are lacking. METHODS In this multicenter diffusion magnetic resonance imaging study (261 iRBD, 177 controls), free ...
Celine Haddad, Véronique Daneault, Violette Ayral, Marie Filiatrault, Alexandre Pastor‐Bernier, Christina Tremblay, Arnaud Boré, Maxime Descoteaux, Andrew Vo, Jean‐François Gagnon, Ronald B. Postuma, Petr Dusek, Stanislav Marecek, Zsoka Varga, Johannes Klein, Michele T. Hu, Stéphane Lehéricy, Isabelle Arnulf, Marie Vidailhet, Jean‐Christophe Corvol, ICEBERG Study Group, Shady Rahayel   +21 more
wiley   +1 more source

Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Risk factors associated with sporadic non‐amnestic and early‐onset Alzheimer's disease (AD) remain underexamined. METHODS We investigated a large, clinically heterogeneous, AD cohort for frequencies of established risk factors (hypertension, hypercholesterolemia, diabetes mellitus) alongside novel factors (non–right‐handedness ...
Zachary A. Miller, Rik Ossenkoppele, Neill R. Graff‐Radford, Isabel E. Allen, Wendy Shwe, Lynne Rosenberg, Dustin J. Olguin, Michael G. Erkkinen, P. Monroe Butler, Salvatore Spina, Jennifer S. Yokoyama, Rahul S. Desikan, Philip Scheltens, Wiesje van der Flier, Yolande Pijnenburg, Emma Wolters, Rosa Rademakers, Daniel H. Geschwind, Joel H. Kramer, Howard J. Rosen, Katherine P. Rankin, Lea T. Grinberg, William W. Seeley, Virginia Sturm, David C. Perry, Bruce L. Miller, Gil D. Rabinovici, Maria Luisa Gorno‐Tempini   +27 more
wiley   +1 more source

The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract BACKGROUND Tau‐derived cerebrospinal fluid (CSF) biomarkers correlate with amyloid‐beta (Aβ) plaques or tau tangles in Alzheimer's disease (AD). This study assessed the effects of long‐term anti‐Aβ antibodies on amyloid plaques, tau tangles, and CSF tau species to determine the relationships between them.
Eric M. McDade, Nicolas R. Barthélemy, Guoqiao Wang, Yan Li, Yuchen Cao, Brian Gordon, Tammie L. S. Benzinger, David Clifford, Alison M. Goate, Alan E. Renton, Jason Hassenstab, Jorge J. Llibre‐Guerra, Richard J. Perrin, Chengjie Xiong, Carlos Cruchaga, Catherine J. Mummery, Sarah B. Berman, James Lah, Erik D. Roberson, Christopher Van Dyck, Serge Gauthier, Colin L. Masters, Mario Masellis, Tobias Bittner, Roy Yaari, Jasmeer Chhatwal, Patricio Chrem, William Brooks, Kazushi Suzuki, Johannes J. Levin, Mathias Jucker, John Ringman, David Wallon, Takeshi Ikeuchi, Jae‐Hong Lee, Jee Hoon Roh, Peter Schofield, Nick C. Fox, Natalie S. Ryan, Jonathan Vöglein, Celeste Karch, Laura Ibáñez, Gregory S. Day, Raquel Sánchez‐Valle, Alisha Daniels, John C. Morris, Charlene Supnet‐Bell, Allan I. Levey, Randall J. Bateman, The DIAN‐TU Study Team and DIAN Obs Team   +49 more
wiley   +1 more source

Rapid Review of Interventions Designed to Enhance Personalised Care for People With Dementia When There Are Concerns About Reduced Awareness of Difficulties

International Journal of Geriatric Psychiatry, Volume 40, Issue 9, September 2025.
ABSTRACT Objectives Awareness of difficulties varies in people with dementia. Low awareness, also termed anosognosia, has been implicated in carer stress and safety concerns, and can be a barrier to effective clinical communication. Little is known about how to manage situations arising from low awareness.
Catherine M. Alexander, Hannah Earle, Anthony Martyr, Linda Clare   +3 more
wiley   +1 more source

Lifespan Tree of Brain Anatomy: Diagnostic Values for Motor and Cognitive Neurodegenerative Diseases

Human Brain Mapping, Volume 46, Issue 13, September 2025.
The lifespan tree of brain anatomy improves multiclass differential diagnosis of neurodegenerative diseases by modeling brain volume changes over time. It outperforms SVM, provides interpretable disease trajectories, and enhances real‐world clinical applicability.
Pierrick Coupé, Boris Mansencal, José V. Manjón, Patrice Péran, Wassilios G. Meissner, Thomas Tourdias, Vincent Planche   +6 more
wiley   +1 more source