Results 31 to 40 of about 10,373 (113)

Use of anti–amyloid‐β monoclonal antibodies in persons with Down syndrome Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The recent development and licensing of anti–amyloid‐β monoclonal antibodies for the treatment of early‐stage Alzheimer's disease have significantly shifted the clinical landscape. However, current use recommendations preclude the administration of these new drugs to persons who have Down syndrome.
Clíona Farrell, Fedal Saini, Mona M. Beidas, Natalie S. Ryan, Andre Strydom, Frances K. Wiseman   +5 more
wiley   +1 more source

Examining language functions: a reassessment of Bastian's contribution to aphasia assessment [PDF]

, 2013
Henry Charlton Bastian (1837–1915) developed his network model of language processing, modality deficits and correlated lesion localizations in the 1860s and was a leading clinical authority for over four decades. Although his ideas are little referenced
Lorch, Marjorie
core   +1 more source

Sleep enhances gamma oscillations in the seizure onset zone and broadband activity in the irritative zone of focal cortical dysplasia

Epilepsia Open, Volume 11, Issue 2, Page 435-451, April 2026.
Abstract Objective Focal cortical dysplasia (FCD) is a leading cause of drug‐resistant epilepsy and is associated with sleep‐related seizures, yet the underlying electrophysiological mechanisms during different brain states remain poorly understood. We investigated whether fast oscillations (FOs) within the seizure onset zone (SOZ) and irritative zone (
Mohammad F. Khazali, Nina Schwoon, Armin Brandt, Matthias Dümpelmann, Yiwen Li Hegner, Nicolas Roehri, Dirk‐Matthias Altenmüller, Victoria San Antonio‐Arce, Peter C. Reinacher, Julia M. Nakagawa, Soroush Doostkam, Theo Demerath, Horst Urbach, Andreas Schulze‐Bonhage, Marcel Heers   +14 more
wiley   +1 more source

Identification of sex hormone-binding globulin in the human hypothalamus [PDF]

, 2005
Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin ( SHBG) may act by a non-genomic mechanism independent of classical steroid receptors.
Becchis M, Caldwell JD, Caldwell JD, Caldwell JD, Caldwell JD, Christian Melle, Englebienne P, Fassler R, Feldman M, Ferdinand von Eggeling, Forunati N, Gao G, Gustav F. Jirikowski, Hammond GL, Hans-Gert Bernstein, Herbert Z, Hoskins EK, Hryb DJ, Jack D. Caldwell, Jirikowski GF, John Lewis, Joseph DR, Khan MS, Krupenko SA, Lewis JG, Melle C, Paoletti AM, Pardridge WM, Remington SG, Reventos J, Rosner W, Selva DM, Susanne Göthe, Vigh Teichmann I, Wang YM, Zsófia Herbert   +35 more
core   +1 more source

Shared genetic variants across substance use disorders implicate common neurobiological pathways, a genome‐wide mixed methods study

General Psychiatry, Volume 39, Issue 2, April 2026.
ABSTRACT Background Substance use disorders (SUDs) are highly heritable, but the extent of shared and distinct genetic architecture across different SUDs is unclear. Aims To compare the genetic architectures of alcohol use disorder (AUD), cannabis use disorder (CUD) and opioid use disorder (OUD) and to identify shared and unique genetic loci.
Børge Holen, Zillur Rahman, Alexey A. Shadrin, Romain Icick, Kevin S. O’Connell, Linn Rødevand, Nadine Parker, Markos Tesfaye, Piotr Jaholkowski, Oleksandr Frei, Anders M. Dale, Srdjan Djurovic, Ole A. Andreassen, Olav B. Smeland   +13 more
wiley   +1 more source

Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi‐cohort study

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Psychological distress has been linked with cognitive impairment. However, whether the relationship is causal, reflects preclinical dementia neuropathology, or confounding by common causes remains unclear. METHODS In five UK longitudinal studies, we examined associations of psychological distress with subsequent cognition using ...
Jean Stafford, Serhiy Dekhtyar, Tom C Russ, Archana Singh‐Manoux, Jane Maddock, Kate Walters, Vasiliki Orgeta, Neil Davies, James B Kirkbride, Marcus Richards, Robert Howard, Praveetha Patalay   +11 more
wiley   +1 more source

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome [PDF]

, 2015
Down syndrome, caused by an extra copy of chromosome 21, is associated with a greatly increased risk of early onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor ...
A Coppus, A Goate, A Hirayama, A Karmiloff-Smith, A Letourneau, A Llado, A Ma'ayan, A Murray, A Patel, A Rovelet-Lecrux, A Rovelet-Lecrux, A Salehi, A Serrano-Pozo, A Strydom, AC Phillips, AH Ropper, AJ Dalton, AJ Holland, AM Cataldo, AMW Coppus, AMW Coppus, André Strydom, Annette Karmiloff-Smith, AW Bero, B Schmidt-Sidor, BL Burgess, BL Handen, BP Wang, BT Hyman, BV Hooli, BV Hooli, C Balducci, C Canzonetta, C Chen, C Mori, C Oliver, CA Lemere, CC Draheim, CF Lippa, CJ Holler, CY Chang, D Adams, D Allsop, D Friedman, D Jennings, D McNaughton, D Powell, D Wallon, DA Devenny, DA Devenny, Dean Nizetic, DM Wilcock, DMA Mann, DMA Mann, DMA Mann, DMA Mann, DMA Mann, DMA Mann, DS Yang, E Head, EA Shukkur, EL Jones, Elizabeth M. C. Fisher, EW Wolvetang, F Fernandez, F Liu, F Struwe, F Yamaguchi, FE Visser, FK Wiseman, Frances K. Wiseman, G Azkona, G d'Orsi, G de Graaf, G Drewes, G Esposito, GA Carlson, GG Glenner, GH Tansley, GM Murphy, H Braak, H Godridge, H Seo, H Thonberg, HM Evenhuis, HM Wisniewski, IH Park, IT Lott, IT Lott, J Busciglio, J Busciglio, J Chapman, J Fraser, J Jiang, J Landt, J Lejeune, J Motte, J Noebels, J Shi, J Tyrrell, J van de Louw, J Wegiel, J Wegiel, JA Hardy, JB deHaan, JB Leverenz, JC Cossec, JC Lambert, JC Moller, JE Donahue, JG Sheng, JH Lee, JH Wu, JH Wu, JHK Choi, JK Teller, JL Vazquez-Higuera, JO Korbel, John Hardy, JP Weick, JS Anderson, K Kasuga, K Murakami, K Sleegers, KA Gyure, KA Vossel, KE Wisniewski, KE Wisniewski, KS Naito, KT Chang, KY Mok, L Cabrejo, L Crayton, L Mucke, L Torroja, L Zhu, LB Li, LBJ McIntire, LD Nelson, LD Nelson, LJ Whalley, M Adorno, M Bothwell, M Goedert, M McCarron, M Nicolas, M Picard, M Vilardell, MC Irizarry, MC Masters, MC Phillips, MC Royston, MJ Ball, MJ Stampfer, ML Margallo-Lana, MO McCarron, MP Cosgrave, MS Cheon, N Schupf, N Schupf, P Zis, PC Burger, PJW Naude, PM Moran, PV Belichenko, QS Xue, R De Simone, R Egensperger, R Kimura, RA Armstrong, S Barbosa, S Deb, S Govoni, S Griffiths-Jones, S Horvath, S Moore, S Swaminathan, S Swaminathan, S Takashima, S Ylaherttuala, SA Cooper, SA Purro, SJ Krinsky-McHale, SJ Krinsky-McHale, SL Ball, SL Ball, SL Hartley, SM Mills, SR Ryoo, SV Matveev, T Iwatsubo, T Lu, T Mendel, T Mori, Tamara Al-Janabi, V Brault, V Cvetkovska, V Dorval, VH Perry, Victor L. J. Tybulewicz, VP Prasher, VP Prasher, VP Prasher, WB Zigman, WB Zigman, WB Zigman, WB Zigman, WK Dowjat, WRG Gibb, WS Kim, WST Griffin, X Wang, XL Sun, Y Hibaoui, Y Jiang, Y Stern, YC Shi, YH Li, YL Woods, YS Davidson   +219 more
core   +1 more source

Advancing global precision in dementia research: Examining Normative Heterogeneity of Aging and Neurodegeneration in Chinese Elders (ENHANCE)

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract The Examining Normative Heterogeneity of Aging and Neurodegeneration in Chinese Elders (ENHANCE) project addresses gaps in Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD) research by prioritizing Chinese‐speaking communities—an underrepresented but rapidly growing population in the United States (US) and globally ...
Boon Lead Tee, Jessica Spat‐Lemus, Spencer Xinyi Zhang, Shreya Upendra, Xinge Zhao, GuanXue Chen, Yu Chen, Xin Wen, Anna Yao, FangDa Leng, Clara Li   +10 more
wiley   +1 more source

Can oral infection be a risk factor for Alzheimer’s disease? [PDF]

, 2015
Alzheimer’s disease (AD) is a scourge of longevity that will drain enormous resources from public health budgets in the future. Currently, there is no diagnostic biomarker and/or treatment for this most common form of dementia in humans.
Alzheimer A, Ball MJ, Bünzli D, Cicci[ugrave] M, Dunn N, Hachinsky V, Ingar Olsen, Kovács T, Lin WR, Miklossy J, Mori I, Oldfield BJ, Ouerfurth HW, Regitz C, Sim K. Singhrao, Song Y, Urovesic N, Whittum-Hudson JA   +17 more
core   +2 more sources

Accelerating real‐world prediction and research in Alzheimer's: The M3AD study

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Chronic diseases, including Alzheimer's disease (AD) and related dementia (ADRD), do not exist solely as isolated entities. Instead, they weave concomitant trajectories of multiple diseases, conditions, behaviors, and risks, mutually influencing each other's course and natural history, in ways yet unexplored.
Moïse Desvarieux, Tatjana Rundek, Habibul Ahsan, Javier Narvaez, Felipe Diaz, Daniel Malinsky, Luis Marco Ruiz, Maxim Topaz, Thomas Falconer, Karthik Natarajan, James Noble, Barbara Entwisle, Deepthi Puram, Tara Anand, Hsin Yi Chen, Xinzhuo Jiang, Yian Gu, Alan Cohen, Mary Beth Terry, Brandon Pierce, Howard Andrews, Emily Rogalsky, Shahla Farzana, George Gulotta, John Beard, Danielle Landron, Samuel L Volchenboum, Philippe Ravaud, Julie Johnson, Ezra Susser, Andrew Rundle, Ying Wei, Nick Tsinoremas, David Loewenstein, Linda Fried, Allison Aiello, Richard Mayeux, George Hripcsak   +37 more
wiley   +1 more source