Results 11 to 20 of about 1,936 (76)
A lifespan staging model of basal forebrain cholinergic vulnerability. [PDF]
Alzheimers DementAbstract The cholinergic neurons of the basal forebrain are among the most vulnerable cell types to age‐ and Alzheimer's disease‐related dysfunction and neurodegeneration. However, the biological bases of basal forebrain cholinergic vulnerability (the why) and the temporal sequence (the how) have yet to be fully resolved.
Shanks HRC +3 more
europepmc +2 more sources
High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena +7 more
wiley +1 more source
Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies
Brain Pathology, EarlyView.Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom +7 more
wiley +1 more source
Brain Pathology, EarlyView.Using the Infinium MethylationEPIC v2.0 array and Heidelberg Brain Tumor Classifier v12.8, 24 international laboratories achieved highly reproducible CNS tumor classification (97.9% correct; median β‐correlation r = 0.99), while copy number variation interpretation showed substantial interlaboratory variability, highlighting the need for harmonized CNV
Katrin Mauch‐Mücke +50 more
wiley +1 more source
A Comparative Study of Aging and Cortical Folding in Chimpanzees and Olive Baboons
American Journal of Primatology, Volume 88, Issue 7, July 2026.This figure shows 3D renderings of a chimpanzee (top) and olive baboon (bottom) brain with each sulcus label used in this study. After sulci were labeled, we exported metrics including mean depth and fold opening (width) of each sulcus to examine age‐related changes in these measures, as well as sex differences within species.
William D. Hopkins +7 more
wiley +1 more source
Early and Progressive Spinal Cord Atrophy in Spinocerebellar Ataxia Type 1
Movement Disorders, Volume 41, Issue 7, Page 1836-1846, July 2026.Abstract Background Spinocerebellar ataxia type 1 (SCA1) is a rare, autosomal dominant neurodegenerative disorder characterized by progressive cerebellar and brainstem degeneration. Previous studies have shown that spinal cord atrophy is also a key aspect of SCA1 neuropathology.
Colette J.M. Reniers +11 more
wiley +1 more source
Brain Pathology, Volume 36, Issue 4, July 2026.Proteomics‐guided exome re‐analysis identifies bi‐allelic variants in the nuclear envelope LEMD2 gene, expanding its phenotypic spectrum. Created in BioRender. Pauper, M. (2026) https://BioRender.com/xamvo92.
Marc Pauper +17 more
wiley +1 more source
Emerging directions in tauopathy research
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of
Luc Buée +41 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Growing evidence supports a critical role of sleep slow waves (SW) in Alzheimer's disease (AD). However, wake SW (sleep‐like SW potentially reflecting local intrusions of sleep) remain unexplored in AD. METHODS A total of 274 older adults with subjective cognitive decline (SCD) (INSIGHT‐preAD cohort, 76.6 ± 3.5 years) underwent (i)
Pierre Champetier +14 more
wiley +1 more source
The include network: Advancing cross‐linguistic equity in brain health research
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Speech and language measures are increasingly recognized as sensitive, scalable, non‐invasive markers of diverse brain disorders. Yet, current research is overwhelmingly English‐centric, neglecting the world's vast linguistic diversity and undermining these markers’ global applicability.
Adolfo M. García +13 more
wiley +1 more source