Results 31 to 40 of about 10,376 (110)
Frontotemporal dementia and its subtypes: a genome-wide association study [PDF]
, 2014 SummaryBackground Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability.Al Pijnenburg, Yolande, Alexopoulos, Panagiotis, Alonso, Elena, Anfossi, Maria, Attems, Johannes, Baborie, Atik, Bagnoli, Silvia, Baker, Matt, Bartley, Lauren, Benussi, Luisa, Bernardi, Livia, Binetti, Giuliano, Blesa, Rafael, Boada, Merce, Boeve, Bradley F., Borroni, Barbara, Brice, Alexis, Brooks, William S., Bruni, Amalia C., Cairns, Nigel J., Capozzo, Rosa, Cappa, Stefano F., Chiang, Huei-Hsin, Clarimon, Jordi, Collinge, John, Conidi, Maria Elena, Cruchaga, Carlos, Cruts, Marc, Cupidi, Chiara, Danek, Adrian, Deramecourt, Vincent, Deschamps, William, Dickson, Dennis W., Diehl-Schmid, Janine, Dobson-Stone, Carol, Dopper, Elise G. P., et al., Fenoglio, Chiara, Ferrari, Raffaele, Ferrucci, Luigi, Forloni, Gianluigi, Fox, Nick C., Franceschi, Massimo, Frangipane, Francesca, Galimberti, Daniela, Gallo, Maura, Gasparoni, Gilles, Gerhard, Alexander, Ghidoni, Roberta, Giaccone, Giorgio, Golfier, Veronique, Graff, Caroline, Graff-Radford, Neill R., Grafman, Jordan, Griffiths, Timothy D., Grossman, Murray, Gu, Wei, Haan, Eric, Halliday, Glenda M., Hannequin, Didier, Hardy, John, Hernandez, Dena G., Hernandez, Isabel, Heutink, Peter, Hjermind, Lena E., Hodges, John R., Hsiung, Ging-Yuek R., Huey, Edward D., Ibach, Bernd, Jaros, Evelyn, Josephs, Keith A., Kapogiannis, Dimitrios, Karydas, Anna M., Knopman, David, Kristiansen, Mark, Kurz, Alexander, Kwok, John B. J., Le Ber, Isabelle, Lebert, Florence, Lleo, Alberto, Logroscino, Giancarlo, Mackenzie, Ian R. A., Maletta, Raffaele, Mann, David M. A., Mayhaus, Manuel, McKeith, Ian G., Mead, Simon, Milan, Graziella, Miller, Bruce L., Momeni, Parastoo, Morris, Christopher M., Morris, Huw R., Nacmias, Benedetta, Nalls, Michael A., Nielsen, Jorgen E., Nilsson, Christer, Nilsson, Karin, Novelli, Valeria, Ortega-Cubero, Sara, Padovani, Alessandro, Parisi, Joseph E., Pasquier, Florence, Pastor, Pau, Perneczky, Robert, Petersen, Ronald C., Piaceri, Irene, Pichler, Sabrina, Pickering-Brown, Stuart, Pietrini, P., Piguet, Olivier, Pinessi, Lorenzo, Postiglione, Alfredo, Puca, Annibale A., Rademakers, Rosa, Rainero, Innocenzo, Ramasamy, Adaikalavan, Razquin, Cristina, Richardson, Anna, Riemenschneider, Matthias, Rizzu, Patrizia, Rogaeva, Ekaterina, Rohrer, Jonathan D., Rollin, Adeline, Rollinson, Sara, Rosen, Howard, Rossi, Giacomina, Rossor, Martin N., Rowe, James B., Rubino, Elisa, Ruiz, Agustin, Scarpini, Elio, Scheltens, Philip, Schlachetzki, Johannes C. M., Schofield, Peter R., Seelaar, Harro, Seeley, William W., Serpente, Maria, Singleton, Andrew B., Smirne, Nicoletta, Snowden, Julie S., Sorbi, Sandra, Sorrentino, Paolo, Spillantini, Maria Grazia, St George-Hyslop, Peter, Tagliavini, Fabrizio, Thomas, Alan J., Thompson, Elizabeth, Tierney, Michael C., Trojanowski, John Q., Uphill, James, Van Broeckhoven, Christine, Van Deerlin, Vivianna M., van der Zee, Julie, Van Langenhove, Tim, van Swieten, John C., Vercelletto, Martine, Waldo, Maria Landqvist, Warren, Jason D., Wassermann, Eric M. +158 morecore +1 more sourceDSOK‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model
International Journal of Eating Disorders, Volume 59, Issue 1, Page 54-69, January 2026.ABSTRACT Objective
Anorexia nervosa (AN) is a metabolic‐psychiatric disorder characterized by severe weight loss, hypercortisolemia, and hypothalamic–pituitary–adrenal (HPA) axis activation. In this study, we investigated the effect of inhibiting cortisol regeneration via the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) on the ...Hiroki Kawai, Nanami Wada, Shinji Sakamoto, Kenji Miyazaki, Taro Kato, Yoshihiro Horiuchi, Hiroshi Kirii, Hoang Duy Nguyen, Kenji Hinotsu, Yoshio Ohya, Takahiro Asada, Akiyoshi Yokode, Yuko Okahisa, Haruko Miyazaki, Toshitaka Oohashi, Manabu Takaki +15 morewiley +1 more sourcecIMPACT‐NOW update 11: Proposal on adaptation of diagnostic criteria for IDH‐ and H3‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors
Brain Pathology, Volume 36, Issue 1, January 2026.Abstract
The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.Pieter Wesseling, David Capper, Guido Reifenberger, Chitra Sarkar, Cynthia Hawkins, Arie Perry, Bette Kleinschmidt‐DeMasters, Takashi Komori, Werner Paulus, Vani Santosh, Martin van den Bent, Michael Weller, Stefan M. Pfister, Uri Tabori, Dominique Figarella‐Branger, Brent A. Orr, David N. Louis +16 morewiley +1 more sourceA genetic cause of Alzheimer disease: mechanistic insights from Down syndrome [PDF]
, 2015 Down syndrome, caused by an extra copy of chromosome 21, is associated with a greatly increased risk of early onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor ...A Coppus, A Goate, A Hirayama, A Karmiloff-Smith, A Letourneau, A Llado, A Ma'ayan, A Murray, A Patel, A Rovelet-Lecrux, A Rovelet-Lecrux, A Salehi, A Serrano-Pozo, A Strydom, AC Phillips, AH Ropper, AJ Dalton, AJ Holland, AM Cataldo, AMW Coppus, AMW Coppus, André Strydom, Annette Karmiloff-Smith, AW Bero, B Schmidt-Sidor, BL Burgess, BL Handen, BP Wang, BT Hyman, BV Hooli, BV Hooli, C Balducci, C Canzonetta, C Chen, C Mori, C Oliver, CA Lemere, CC Draheim, CF Lippa, CJ Holler, CY Chang, D Adams, D Allsop, D Friedman, D Jennings, D McNaughton, D Powell, D Wallon, DA Devenny, DA Devenny, Dean Nizetic, DM Wilcock, DMA Mann, DMA Mann, DMA Mann, DMA Mann, DMA Mann, DMA Mann, DS Yang, E Head, EA Shukkur, EL Jones, Elizabeth M. C. Fisher, EW Wolvetang, F Fernandez, F Liu, F Struwe, F Yamaguchi, FE Visser, FK Wiseman, Frances K. Wiseman, G Azkona, G d'Orsi, G de Graaf, G Drewes, G Esposito, GA Carlson, GG Glenner, GH Tansley, GM Murphy, H Braak, H Godridge, H Seo, H Thonberg, HM Evenhuis, HM Wisniewski, IH Park, IT Lott, IT Lott, J Busciglio, J Busciglio, J Chapman, J Fraser, J Jiang, J Landt, J Lejeune, J Motte, J Noebels, J Shi, J Tyrrell, J van de Louw, J Wegiel, J Wegiel, JA Hardy, JB deHaan, JB Leverenz, JC Cossec, JC Lambert, JC Moller, JE Donahue, JG Sheng, JH Lee, JH Wu, JH Wu, JHK Choi, JK Teller, JL Vazquez-Higuera, JO Korbel, John Hardy, JP Weick, JS Anderson, K Kasuga, K Murakami, K Sleegers, KA Gyure, KA Vossel, KE Wisniewski, KE Wisniewski, KS Naito, KT Chang, KY Mok, L Cabrejo, L Crayton, L Mucke, L Torroja, L Zhu, LB Li, LBJ McIntire, LD Nelson, LD Nelson, LJ Whalley, M Adorno, M Bothwell, M Goedert, M McCarron, M Nicolas, M Picard, M Vilardell, MC Irizarry, MC Masters, MC Phillips, MC Royston, MJ Ball, MJ Stampfer, ML Margallo-Lana, MO McCarron, MP Cosgrave, MS Cheon, N Schupf, N Schupf, P Zis, PC Burger, PJW Naude, PM Moran, PV Belichenko, QS Xue, R De Simone, R Egensperger, R Kimura, RA Armstrong, S Barbosa, S Deb, S Govoni, S Griffiths-Jones, S Horvath, S Moore, S Swaminathan, S Swaminathan, S Takashima, S Ylaherttuala, SA Cooper, SA Purro, SJ Krinsky-McHale, SJ Krinsky-McHale, SL Ball, SL Ball, SL Hartley, SM Mills, SR Ryoo, SV Matveev, T Iwatsubo, T Lu, T Mendel, T Mori, Tamara Al-Janabi, V Brault, V Cvetkovska, V Dorval, VH Perry, Victor L. J. Tybulewicz, VP Prasher, VP Prasher, VP Prasher, WB Zigman, WB Zigman, WB Zigman, WB Zigman, WK Dowjat, WRG Gibb, WS Kim, WST Griffin, X Wang, XL Sun, Y Hibaoui, Y Jiang, Y Stern, YC Shi, YH Li, YL Woods, YS Davidson +219 morecore +1 more sourceTissue‐Resident Myeloid and Histiocytic Cells in Health and Disease: Novel Emerging Concepts
American Journal of Hematology, Volume 100, Issue 12, Page 2305-2319, December 2025.ABSTRACT
Although all myeloid cells are considered to derive from hematopoietic stem cells, the cells in each myeloid lineage are heterogeneous populations, and their distribution and functions vary, depending on underlying physiologic and pathologic processes, age, sex, and genetic and epigenetic signatures.Peter Valent, Johann Wojta, Petri T. Kovanen, Olivier Hermine, Falko Fend, Karl Sotlar, Hildegard Greinix, Klaus Geissler, Karin Hartmann, Juliana Schwaab, Marco Herling, Laura Boccuni, Lukas Kazianka, Max Vincent John, Wolfgang R. Sperr, Carina Zierfuss, Alexandar Tzankov, Christian Sillaber, Milen Minkov, Gregor Hoermann, Matthew Collin, Hans‐Peter Horny, Torsten Haferlach, Maria Sibilia, Julien Haroche, Paul La Rosée, Alberto Orfao, Michel Arock +27 morewiley +1 more sourceOligogenic inheritance of optineurin (OPTN) and C9ORF72 mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions of C9ORF72-ALS. [PDF]
, 2015 Amyotrophic lateral sclerosis (ALS) is characterized by motor neurone loss resulting in muscle weakness, spasticity and ultimately death. 5-10% are caused by inherited mutations, most commonly C9ORF72, SOD1, TARDBP and FUS.Al-Sarraj, Albagha, Anborgh, Ash, Belzil, Blitterswijk, Blitterswijk, Buchman, Byrne, Cady, Chio, Chio, Cooper-Knock, Cooper-Knock, Cooper-Knock, Dejesus-Hernandez, Hewitt, Hortobagyi, Iida, Iida, Ince, Ince, Johnson, Kachaner, Kenna, Kirby, Kirby, Korac, Liu, Majounie, Maruyama, McCombe, McDermott, Millecamps, Mori, Mori, Osawa, Renton, Renton, Rezaie, Rosen, Schwab, Schwamborn, Shen, Solski, Sreedharan, Toro, Tumer, Weishaupt, Wong, Ying, Zhang +51 morecore +1 more sourceThe Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong +31 morewiley +1 more sourceAngiotensin II-inhibition:effect on Alzheimer's pathology in the aged triple transgenic mouse [PDF]
, 2012 Reducing excessive accumulation of amyloid-β (Aβ) in Alzheimer's disease (AD) is a key objective of most AD therapies, and inhibition of angiotensin-converting enzyme (ACE) may delay onset or progression of AD. The effects of an ACE-inhibitor (ACE-I) and Ferrington, Linda, Horsburgh, Karen J, Kehoe, Patrick G, Kelly, Paul At, Love, Seth, Palmer, Laura E +5 morecore +6 more sources
