Results 101 to 110 of about 313,545 (301)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Multiplexing a serial array of tapered optical fibre sensors using coherent optical frequency domain reflectometry [PDF]

, 2012
The use of high spatial resolution optical frequency domain reflectometry (OFDR) to facilitate the multiplexing of a serial array of tapered optical fibre sensors is presented.
Tatam, Ralph P., Chehura, Edmon, James, Stephen W., Jarzebinska, Renata   +3 more
core   +1 more source

A Study on Coupling Faults’ Characteristics of Fixed-Axis Gear Crack and Planetary Gear Wear

Shock and Vibration, 2018
To identify the fault frequency characteristics of the gear transmission system under coupling fault of fixed-axis gear crack and planetary gear wear, dimensionless dynamical equations of gear transmission system were established.
Xin Wang
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Measurement of the coupling constant in a two-frequency VECSEL

Optics Express, 2010
We measure the coupling constant between the two perpendicularly polarized eigenstates of a two-frequency Vertical External Cavity Surface Emitting Laser (VECSEL). This measurement is performed for different values of the transverse spatial separation between the two perpendicularly polarized modes.
Pal, V., Trofimoff, P., Miranda, B.-X., Baili, Ghaya, Alouini, Mehdi, Morvan, Loïc, Dolfi, Daniel, Goldfarb, Fabienne, Sagnes, Isabelle, Ghosh, R., Bretenaker, Fabien   +10 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Light-activated modulation and coupling in integrated polymer-liquid crystal systems [PDF]

, 2014
We explore the transfer of an incident light pattern onto the liquid crystal (LC) bulk in a photorefractive cell through an integrated photoconducting layer that modulates the electric field applied to the device.
Buchnev, Oleksandr, Kaczmarek, Malgosia, Podoliak, Nina, Bateman, James, Proctor, Matthew B., Daly, Keith, D'Alessandro, Giampaolo, Herrington, Mark   +7 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Evolution of cardiorespiratory interactions with age [PDF]

, 2013
We describe an analysis of cardiac and respiratory time series recorded from 189 subjects of both genders aged 16–90. By application of the synchrosqueezed wavelet transform, we extract the respiratory and cardiac frequencies and phases with better time ...
Iatsenko, D., Clarkson, P.B.M., Stefanovska, A., Owen-Lynch, P.J., Clarkson, Peter B. M., Bernjak, A., Shiogai, Yuri, Shiogai, Y., McClintock, P.V.E., Stankovski, Tomislav, Owen-Lynch, P. Jane, Stefanovska, Aneta, Iatsenko, Dima, McClintock, Peter V. E., Bernjak, Alan, Stankovski, T.   +15 more
core   +1 more source

Multivariate cross-frequency coupling via generalized eigendecomposition

eLife, 2017
This paper presents a new framework for analyzing cross-frequency coupling in multichannel electrophysiological recordings. The generalized eigendecomposition-based cross-frequency coupling framework (gedCFC) is inspired by source-separation algorithms ...
Michael X Cohen
doaj   +1 more source