Results 111 to 120 of about 313,545 (301)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Fluid coupling between the elements in a discrete model of cochlear mechanics
, 2010 When analysing the coupled mechanics of the cochlea, due to the interaction between fluid coupling and basilar membrane motion, it is convenient to divide the cochlea longitudinally into a discrete number of sections.
Ni, G., Elliott, S.J., Lineton, B.
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
PLoS ONE, 2019 The self-synchronization of rotors mounted on different vibrating bodies can be easily controlled by adjusting the coupling parameters. To reveal the synchronization characteristics of a weakly damped system with two rotors mounted on different vibrating
Bang Chen, Xiao'ou Xia, Xiaobo Wang
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2010 The purpose of this study is to investigate the influence of hull flexibility on the hydrodynamic forces and moments associated with liquid sloshing, as well as the dynamic characteristics = (e.g. resonance frequencies) of the whole system.
Tan, M. +3 more
core
Hybrid nanomechanical systems embedding a quantum light emitter, such as a semiconductor quantum dot (QD), are actively investigated both for their fundamental interest and for potential applications to quantum information technologies.
Julien Claudon (9980345) +10 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Mutual Coupling Reduction Techniques in Electronic Steering Antennas in X Band
, 2011 This work provides the development of an antenna for satellite communications onboard systems based on the recommendations ITU-R S.580-6 [1] and ITU-R S.465-5 [2].
Fernández González, José Manuel +3 more
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