Results 71 to 80 of about 313,545 (301)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The electromagnetic effect study of GIS enclosure under high-frequency electromagnetic pulse

The Journal of Engineering, 2019
In gas insulated switchgear (GIS) substation, due to the operation of disconnect switch and circuit breaker, as well as short-circuit fault, SF6 will break down very rapidly.
Shu Chen, Jie Guo, Chengbo Hu, Fengbo Tao, Tianxi Xie, Yang Xu, Jun Jia   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

A new method for Synthetic Impulse and Aperture Radar transmitting waveform design based on non‐sequential positive, negative and random carrier frequency coding with dot product approach

IET Radar, Sonar & Navigation, 2022
Synthetic Impulse and Aperture Radar (SIAR) is a kind of Multiple Input Multiple Output (MIMO) radar. It is a four‐dimensional radar that has advantages against stealth targets, multi targets, anti‐radiated missile, reconnaissance and interference, as ...
Pourya Yaghoubi Aliabad, Hossein Soleimani, Mohammad Soleimani   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Frequency conversion based on three-wave parametric solitons [PDF]

, 2010
Parametric three-wave mixing in quadratic nonlinear crystals provides a versatile means of achieving widely tunable frequency conversion of laser light, thus permitting a substantial extension of the wavelength coverage of laser sources across broad ...
Degasperis, Antonio, A. DE GASPERIS, de Angelis, Costantino, Wabnitz, Stefan, DE ANGELIS C, Lombardo, Sara, S. LOMBARDO, CONFORTI M, DE GASPERIS, Antonio, Baronio, Fabio, Matteo Conforti, BARONIO F, Stefan Wabnitz, Sara Lombardo, Costantino De, Conforti, Matteo, Fabio Baronio, Antonio Degasperis   +17 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microsrip Ring Antennas Operating at Higher-Oder Modes for Mobile Communications [PDF]

, 1995
An experimental study of microstrip ring antennas suitable for use in mobile communication systems is presented. Conical radiated beams are generated by the TM(21) and TM(41) modes.
Langley, Richard J., Batchelor, John C.
core   +1 more source