Results 91 to 100 of about 4,543,260 (298)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Hierarchical bases for non-hierarchic 3Dtriangular meshes [PDF]
, 2008 We describe a novel basis of hierarchical, multiscale functions that are linear combinations of standard Rao-Wilton- Glisson (RWG) functions. When the basis is used for discretizing the electric field integral equation (EFIE) for PEC objects it gives ...
Vecchi, Giuseppe +2 more
core +1 more source
Here I unify frequency across the domains, using Venus...as my guide...sounds crazy...it works..I DID IT!!!!! Yayayayayay I actually did it!!!! Yay me!!
openaire +4 more sources
Description of Multichannel Amplification in Semiconductor Optical Amplifier
International Journal of Engineering Business Management, 2012 In this paper, a generalized equation of pulse propagation in semiconductor optical amplifier (SOA) under the effects of four wave mixing (FWM) has been derived.
Sadiq Jaafar Kadhim +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Neumann problem on the semi-line for the Burgers equation [PDF]
, 2011 In this article, the Neumann problem on the semi-line for the Burgers equation is considered. The problem is reduced to a nonlinear integral equation in one independent variable, whose unique solution is proven to exist for small time.
Sommacal, Matteo, de Lillo, Silvana
core +1 more source
SensorsBased on the energy equation of the hemispherical resonator, this study analyzes the influence of ion beam balancing on the frequency split of the hemispherical resonator.
Boran Li, Changhong Wang, Zhen Fang
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Jixie chuandong, 2014 Based on Lagrange equation,the vibration equation of the belt drive mechanism with strongly nonlinear is established.By means of the method of L-P,the primary resonance of the belt drive mechanism system with strongly nonlinear is analyzed.The amplitude ...
李高峰
doaj