Results 111 to 120 of about 2,195,899 (341)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Estimate of intense rainfall equation parameters for rainfall stations of the Paraíba State, Brazil

Pesquisa Agropecuária Tropical, 2017
Rainfall is the primary water source for hydrographic basins. Hence, the quantification and knowledge of its temporal and spatial distribution are indispensable in dimensioning hydraulic projects.
Alcinei Ribeiro Campos, João Batista Lopes da Silva, Glenio Guimarães Santos, Rafael Felippe Ratke, Itauane Oliveira de Aquino   +4 more
doaj   +1 more source

EXACT SOLUTIONS OF THE HIGHER-ORDER NONLINEAR SCHR\"{O}DINGER EQUATION WITH CUBIC-QUINTIC NONLINEARITIES, SELF-STEEPING AND SELF-FREQUENCY SHIFT EFFECTS [PDF]

, 2016
M. M. Hassan, N. H. Abdel-Wahab, M.S. Abdel-Daym   +2 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Synchronization of Two Non-Identical Coupled Exciters in a Non-Resonant Vibrating System of Linear Motion. Part I: Theoretical Analysis

Shock and Vibration, 2009
In this paper an analytical approach is proposed to study the feature of frequency capture of two non-identical coupled exciters in a non-resonant vibrating system.
Chunyu Zhao, Hongtao Zhu, Ruizi Wang, Bangchun Wen   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Analysis of the Main Factors Influencing the Dominant Frequency of Blast Vibration

Shock and Vibration, 2019
At present, the study on the dominant frequency of blasting vibration is still a worldwide problem. Compared with the mature research on the particle peak velocity of blasting vibration, the researches on the dominant frequency of blasting vibration are ...
Da Liu, Wenbo Lu, Yijia Liu, Ming Chen, Peng Yan, Pengchang Sun   +5 more
doaj   +1 more source

Low frequency acoustic and electromagnetic scattering [PDF]

This paper deals with two classes of problems arising from acoustics and electromagnetics scattering in the low frequency stations. The first class of problem is solving Helmholtz equation with Dirichlet boundary conditions on an arbitrary two ...
Hariharan, S. I., Maccamy, R. C.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Exact solution of the differential equation of transverse oscillations of the rod taking into account own weight

MATEC Web of Conferences, 2017
The free transverse oscillations of the rod of uniform cross section taking into account its own weight are considered in this work. The appropriate partial differential equation of transverse oscillations of a rod was reduced to two ordinary ...
Krutii Yurii, Suriyaninov Mykola, Vandynskyi Victor   +2 more
doaj   +1 more source