Results 131 to 140 of about 499,713 (313)
High-intensity focused ultrasound ablation by the dual-frequency excitation
, 2018 High-intensity focused ultrasound (HIFU) has emerged as an effective and noninvasive therapeutic modality for cancer and solid tumor. Despite its promising clinical outcomes and the approval of the Food and Drug Administration of many countries, the ...
Zhou, Yufeng, Law, Berlinda Siu Kwun
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
This whitepaper introduces the MEI5 Time-Frequency Equation, a novel mathematical model for time distortion (Delta t) using modulation strength (mu), environmental resonance (r), and universal physical constants. Derived from Planck’s and Einstein’s principles, this equation enables measurable, repeatable synchronization behavior in systems with no ...
openaire +2 more sources
Nonlinear Transformation of Differential Equations into Phase Space
EURASIP Journal on Advances in Signal Processing, 2004 Time-frequency representations transform a one-dimensional function into a two-dimensional function in the phase-space of time and frequency. The transformation to accomplish is a nonlinear transformation and there are an infinite number of such ...
Galleani Lorenzo, Cohen Leon
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2008 This brief paper provides a novel derivation of the known asymptotic values of three-dimensional (3D) added mass and damping of marine structures in waves.
Fossen, Thor I., Perez, Tristan
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Second-order moments of frequency asymmetric cycles [PDF]
Second-order moments, as even functions in time, are conventionally regarded as containing no information about the time irreversible nature of a sequence and therefore about its frequency asymmetry. However, this paper shows that the frequency asymmetry
Miguel Artiach
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source