Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
On the geometric phases during radio frequency pulses with sine and cosine amplitude and frequency modulation. [PDF]
AIP Adv, 2023 Sorce DJ, Michaeli S.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
The Influence of Temperature on Frequency Modulation Spectroscopy in Atom Gravimeter. [PDF]
Sensors (Basel), 2022 Weng K +6 more
europepmc +1 more source
Radio Frequency Amplitude-Modulation to Frequency-Modulation Signal Converter
23 pages, 27 figures, equal ...
Parthasarathy, Rishab +2 more
openaire +2 more sources
Modulation Characteristics of Active Frequency Selective Surface Trihedral Corner Reflector
, 2019 Lei Liu +4 more
openalex +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A novel approach to wireless electromagnetic tracking using frequency modulation radio communication. [PDF]
Int J Comput Assist Radiol Surg, 2023 Crowley D +2 more
europepmc +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Deconvolved Fractional Fourier Domain Beamforming for Linear Frequency Modulation Signals. [PDF]
Sensors (Basel), 2023 Liu Z, Tao Q, Sun W, Fu X.
europepmc +1 more source