Results 61 to 70 of about 377,227 (256)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Direction of arrival estimation using the rotating equatorial microphone
Frontiers in Signal ProcessingIntroduction: Direction of arrival (DOA) estimation of sound sources is an essential task of sound field analysis which typically requires two or more microphones. In this study, we present an algorithm that allows for DOA estimation using the previously
Jeremy Lawrence +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Critical modulation frequency and critical band based on random amplitude and frequency changes
Archives of Acoustics, 2014 The presented paper deals with determination of the critical modulation frequency (CMF) and critical bandwidth in the case of random amplitude and frequency changes in a sinusoidal signal.
A. SĘK
doaj
Joint azimuth-range jamming for ISAR based on time delay
The Journal of Engineering, 2019 Aiming at the problem that azimuth cosinusoidal phase-modulation cannot be directly implemented in application, and two-dimensional modulation can only be carried out in azimuth and distance, respectively, a joint azimuth-range jamming method based on ...
Li Botao +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Simulation study on the frequency modulation of sawtooth oscillation by plasma shape in tokamak
Nuclear FusionThis study numerically investigates the impact of the tokamak plasma shape (elongation, triangularity, and aspect ratio) on the amplitude and period of sawtooth oscillations using the three-dimensional toroidal nonlinear magnetic fluid code CLT and the ...
Peijie Zhang +6 more
doaj +1 more source