Results 121 to 130 of about 7,179,590 (297)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Distortion Product Otoacoustic Emission Component Behavior as a Function of Primary Frequency Ratio and Primary Level. [PDF]
Ear Hear, 2022 Durante AS, Shaheen Akhtar U, Dhar S.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Landslide Susceptibility Evaluation of Machine Learning Based on Information Volume and Frequency Ratio: A Case Study of Weixin County, China. [PDF]
Sensors (Basel), 2023 He W +6 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Effect of Loading Frequency Ratio on Multiaxial Asynchronous Fatigue Failure of 30CrMnSiA Steel. [PDF]
Materials (Basel), 2021 Liu T +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Applied SciencesIn response to the shortage of theoretical support for negative sample selection and the imbalance between positive and negative samples in landslide susceptibility assessment (LSA), this study presents a dual optimization framework of sampling strategy ...
Zhen Yang +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Peak-to-average Power Ratio of Orthogonal Frequency Division Multiplexing [PDF]
, 2002 Orthogonal frequency division multiplexing (OFDM) is successfully used in many wireless digital communication systems over multipath channels. One of the principal disadvantages of OFDM is the occurrence of high peak to average power ratios (PAR). Many
Jayalath, Dhammika, Tellambura, Chintha
core