Results 121 to 130 of about 1,755,884 (316)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bootstrapping frequency domain tests in multivariate time series with an application to comparing spectral densities [PDF]

We propose a general bootstrap procedure to approximate the null distribution of nonparametric frequency domain tests about the spectral density matrix of a multivariate time series.
Paparoditis, Efstathios, Dette, Holger
core  

Flood Susceptibility Mapping Using Machine Learning and Geospatial-Sentinel-1 SAR Integration for Enhanced Early Warning Systems

Remote Sensing
This study presents a comprehensive framework for flood susceptibility mapping by integrating geospatial factors with both statistical and machine learning models.
Mahdi Feizbahr, Nicholas Brake, Homayoon Arbabkhah, Hossein Hariri Asli, Kolby Woods   +4 more
doaj   +1 more source

Serum neuronal pentraxin 2 is related to cognitive dysfunction and electroencephalogram slow wave/fast wave frequency ratio in epilepsy. [PDF]

World J Psychiatry, 2023
Huang XF, Xu MX, Chen YF, Lin YQ, Lin YX, Wang F.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Realising the future: forecasting with high frequency based volatility (HEAVY) models [PDF]

This paper studies in some detail a class of high frequency based volatility (HEAVY) models. These models are direct models of daily asset return volatility based on realized measures constructed from high frequency data. Our analysis identifies that the
Neil Shephard, Kevin Sheppard
core  

Least cost path analysis for alternative road network assessment of landslide-prone NH-2, Mizoram, NE India

Geocarto International
Mizoram, one of the hilly states in northeast India, is prone to frequent landslides. Such regular calamities prove to be catastrophic to the road networks of the region.
Jonmenjoy Barman, Brototi Biswas, Jayanta Das, Fahdah Falah Ben Hasher, Mohamed Zhran   +4 more
doaj   +1 more source

Multifrequency controlled synchronization of four inductor motors by the fixed frequency ratio method in a vibration system. [PDF]

Sci Rep, 2023
Jia L, Wang C, Liu Z.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Psychoacoustic Study of Simple-Tone Dyads: Frequency Ratio and Pitch

Acoustics
This study investigates how listeners perceive consonance and dissonance in dyads composed of simple (sine) tones, focusing on the effects of frequency ratio (R) and mean frequency (F).
Stefania Kaklamani, Constantinos Simserides   +1 more
doaj   +1 more source