Results 131 to 140 of about 1,755,884 (316)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Subjective Validity of Figures of Merit for Room Aspect Ratio Design

open access: yes, 2009
Attempts have long been made to classify a room's low frequency audio reproduction capability with regards to its aspect ratio. Common metrics used have relied on the homogeneous distribution of modal frequencies and from these a number of 'optimal ...
Wankling, Matthew, Fazenda, Bruno
core  

Compact Substrate-Integrated Hexagonal Cavity-Backed Self-Hexaplexing Antenna for Sub-6 GHz Applications

open access: yesIEEE Access
A self-multiplexing SIW antenna based on hexagonal SIW cavity is proposed. The structure consists of resonating elements of different sizes, which provide the hexaband operations.
V. Jayaprakash   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Assessment of landslide susceptibility in southeast Xizang Region based on multiple models

open access: yesZhongguo dizhi zaihai yu fangzhi xuebao
The geological environment in southeast Xizang is complicated and disasters occur frequently. Landslides pose a great threat to engineering construction and human and financial safety in the region.
Yeqi ZANG   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Landslide susceptibility analysis on road sections in Kaligesing District, Indonesia, using Frequency Ratio (FR) approaches

open access: yesJournal of Degraded and Mining Lands Management
Road construction with intensive slope cutting increases landslide susceptibility along the road section, especially in hilly areas such as Kaligesing, Indonesia.
Rianita Pertiwi   +3 more
doaj   +1 more source

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