Results 141 to 150 of about 4,057,523 (305)

Landslide susceptibility analysis on road sections in Kaligesing District, Indonesia, using Frequency Ratio (FR) approaches

Journal of Degraded and Mining Lands Management
Road construction with intensive slope cutting increases landslide susceptibility along the road section, especially in hilly areas such as Kaligesing, Indonesia.
Rianita Pertiwi, Junun Sartohadi, M. Anggri Setiawan, Edwin Maulana   +3 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Landslide assessment considering spatial calibration zoning of physical and mechanical parameters of rock and soil mass

Zhongguo dizhi zaihai yu fangzhi xuebao
Landslide hazard assessment is a crucial component of regional landslide disaster risk warning and control. The distributed slope stability quantitative evaluation model SINMAP (stability index mapping) is widely used in landslide hazard assessment ...
Weimin YIN, Yuanyao LI, Xing LI, Ming LI, Le JU, Ou XIE   +5 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cyclone surge inundation susceptibility assessment in Bangladesh coast through geospatial techniques and machine learning algorithms: a comparative study between an island and a mangrove protected area

Frontiers in Earth Science
Tropical cyclones, including surge inundation, are a joint event in the coastal regions of Bangladesh. The surge washes out the life and property within a very short period. Besides, in most cases, the area remains flooded for several days. Prediction of
M. M. Abdullah Al Mamun, M. M. Abdullah Al Mamun, M. M. Abdullah Al Mamun, M. M. Abdullah Al Mamun, Li Zhang, Li Zhang, Yan Xuzhe, Yan Xuzhe, Yan Xuzhe, Bowei Chen, Bowei Chen, Jian Zuo, Jian Zuo, Jian Zuo, Shyamal Karmakar   +14 more
doaj   +1 more source

Human movement and gully erosion: Investigating feedback mechanisms using Frequency Ratio and Least Cost Path analysis in Tigray, Ethiopia. [PDF]

PLoS One, 2021
Nir N, Knitter D, Hardt J, Schütt B.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Repeat Frequency Ratio [PDF]

, 2020
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source