Results 141 to 150 of about 2,229,339 (290)

The high-frequency spectrum of tungsten [PDF]

Journal of the Franklin Institute, 1916
A W, Hull, M, Rice
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Effects of Insole Type and Fatigue on the Electrical Activity of Lower Limb Muscles During Running in Men With Foot Pronation and ACL Reconstruction: A Clinical Trial [PDF]

Journal of Rehabilitation
Objective The purpose of this study was to investigate the effects of different types of insoles and fatigue on the electrical activity of lower limb muscles during running in men with foot pronation (FP) at different post-anterior cruciate ligament ...
Ebrahim Piri, AmirAli Jafarnezhadgero, Mahrokh Dehghani   +2 more
doaj  

Identification approach of acoustic cavitation via frequency spectrum of sound pressure wave signals in numerical simulation. [PDF]

Ultrason Sonochem, 2022
Lin W, Xiao J, Wen J, Wang S.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Controlling for Variable Transposition Rate with an Age-Adjusted Site Frequency Spectrum. [PDF]

Genome Biol Evol, 2022
Horvath R, Menon M, Stitzer M, Ross-Ibarra J.   +3 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

[Frequency, spectrum and risk factors of long COVID]. [PDF]

Inn Med (Heidelb), 2022
Pink I, Welte T.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Signatures of Introgression across the Allele Frequency Spectrum. [PDF]

Mol Biol Evol, 2021
Martin SH, Amos W.
europepmc   +1 more source