Results 91 to 100 of about 175,759 (266)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

CMOS IC master oscillator with quartz frequency stabilization

Технологія та конструювання в електронній апаратурі, 2003
The paper presents the block diagram and functional diagram of the developed CMOS IC, as well as the electrical circuit of the oscillator itself. A calculation method for the oscillator is provided to establish symmetry of its operating point and achieve
V. I. Zolotarevsky, L. I. Samotovka, Yu. D. Mazaletsky, B. A. Balai, E. S. Tovmach, A. F. Voshchinkin   +5 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Red-Pitaya-Based Frequency Stabilization of 1560-nm Fiber Laser to 780-nm Rubidium Atomic Transition via Single-Pass Frequency Doubling

Photonics
The single-step Rydberg excitation of cesium atoms requires a 319 nm ultraviolet laser with a narrow laser linewidth, high frequency stability, and high output power.
Yirong Wei, Ziwen Wang, Yuewei Wang, Yuhui Yang, Tao Wang, Rui Chang, Junmin Wang   +6 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Supersonic combustion instability in a hydrogen-fueled strut-based scramjet combustor

Kongqi donglixue xuebao
Combustion instability is a critical issue limiting the performance and reliability of hypersonic propulsion systems. In this study, Large Eddy Simulation (LES), Fast Fourier Transform (FFT), and Dynamic Mode Decomposition (DMD) were employed to ...
Xiaofei Niu, Qian Chen
doaj   +1 more source

Frequency Stabilization of Nanomechanical Resonators Using Thermally Invariant Strain Engineering. [PDF]

Nano Lett, 2020
Wang M, Zhang R, Ilic R, Aksyuk V, Liu Y.   +4 more
europepmc   +1 more source