Results 91 to 100 of about 508,717 (304)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Features of high-frequency CMOS IС designing for generators with quartz frequency stabilization [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2011
The use of certain circuit and constructive decisions when designing of two variants high-frequency CMOS integrated schemes for generators with quartz stabilization of frequency allowed to considerably improve a number of parameters in comparison with ...
Samotovka V. L., Zolotarevskiy V. I., Voschinkin A. F., Virozub T. M., Verbitskiy V. G., Samotovka L. I.   +5 more
doaj   +2 more sources

A Pathway to Reduce Energy Consumption in the Thermal Stabilization Process of Carbon Fiber Production

Energies, 2018
Process parameters, especially in the thermal stabilization of polyacrylonitrile (PAN) fibers, play a critical role in controlling the cost and properties of the resultant carbon fibers.
Srinivas Nunna, Maxime Maghe, Seyed Mousa Fakhrhoseini, Bhargav Polisetti, Minoo Naebe   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Operation Effect Analysis of Dynamic Stabilizer Considering the Characteristics of Fasteners

Chengshi guidao jiaotong yanjiu
［Objective］ Research is conducted on the influence and significance of the excitation frequency of the dynamic stabilization device and the mechanical characteristics of rail fasteners on the operation effect of the dynamic track stabilizer in order to ...
CHEN Taimao, WANG Lihua, HUANG Hongyi, WANG Jiongli, ZHAO Zemin, JIANG Wei   +5 more
doaj   +1 more source

Calibrating an interferometric laser frequency stabilization to MHz precision

, 2012
We report on a calibration procedure that enhances the precision of an interferometer based frequency stabilization by several orders of magnitude.
Barwood, Birch, Born, Heydemann, Kobtsev, Mack, Scholl   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Frequency stabilization for mobile satellite terminals via LORAN [PDF]

Digital satellite communication systems require careful management of frequency stability. Historically, frequency stability has been accomplished by continuously powered, high cost, high performance reference oscillators.
Ernst, Gregory J., Kee, Steven M., Marquart, Robert C.   +2 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Application of the Feshbach-resonance management to a tightly confined Bose-Einstein condensate

, 2009
We study suppression of the collapse and stabilization of matter-wave solitons by means of time-periodic modulation of the effective nonlinearity, using the nonpolynomial Schroedinger equation (NPSE) for BEC trapped in a tight cigar-shaped potential.
A. J. Leggett, B. A. Malomed, B. A. Malomed, G. Filatrella, I. Towers, L. Salasnich, L. Salasnich, M. C. Gutzwiller   +7 more
core   +1 more source