Results 91 to 100 of about 31,608 (289)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Single-embryo transfer reduces clinical pregnancy rates and live births in fresh IVF and Intracytoplasmic Sperm Injection (ICSI) cycles: a meta-analysis

Reproductive Biology and Endocrinology, 2009
Background It has become an accepted procedure to transfer more than one embryo to the patient to achieve acceptable ongoing pregnancy rates. However, transfers of more than a single embryo increase the probability of establishing a multiple gestation ...
Oliveira João, Pontes Anagloria, Nicoletti Andréia, Petersen Claudia G, Mauri Ana L, Baruffi Ricardo LR, Franco José G   +6 more
doaj   +1 more source

Fresh embryos versus freeze-all embryos - transfer strategies: Nuances of a meta-analysis

JBRA Assisted Reproduction, 2017
The present meta-analysis aimed to evaluate whether the freeze-all strategy (Freeze/All-ET) could bring about improvements in the clinical assisted reproductive technique (ART) outcomes when compared with the fresh embryo transfer strategy (Fresh-ET) in patients undergoing an ART cycle in accordance with the mean number of oocytes collected.A ...
Dieamant, Felipe C, Petersen, Claudia G, Mauri, Ana L, Comar, V., Mattila, Mariana, Vagnini, Laura D, Renzi, Adriana, Petersen, Bruna, Nicoletti, Andreia, Oliveira, João Batista A, Baruffi, Ricardo LR, Franco Jr, Jose G   +11 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Embryo transfer impact: a comprehensive national cohort analysis comparing maternal and neonatal outcomes across varied embryo stages in fresh and frozen transfers

Frontiers in Endocrinology
IntroductionThe utilization of frozen embryo transfer not only enhances reproductive outcomes by elevating the likelihood of live birth and clinical pregnancy but also improves safety by mitigating the risks associated with ovarian hyperstimulation ...
Chih-Ting Chang, Shih-Feng Weng, Shih-Feng Weng, Shih-Feng Weng, Hui-Yu Chuang, I-Le Hsu, Chia-Yi Hsu, Chia-Yi Hsu, Eing-Mei Tsai, Eing-Mei Tsai   +9 more
doaj   +1 more source

Baseline characteristics in matched fresh and deferred frozen-thawed embryo transfer groups.

, 2018
Baseline characteristics in matched fresh and deferred frozen-thawed embryo transfer groups.
Chloé Maignien (5076434), Pietro Santulli (443960), Vanessa Gayet (5076431), Louis Marcellin (697563), Mathilde Bourdon (5076440), Khaled Pocate-Cheriet (5076437), Charles Chapron (443963)   +6 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?

Gynecology Obstetrics & Reproductive Medicine, 2020
OBJECTIVE: Nowadays, fresh embryo transfers and frozen embryo transfers are frequently employed in the treatment of in vitro fertilization. This study aims to compare the pregnancy outcomes in patients who underwent fresh embryo transfers and frozen ...
Ayse Zehra Ozdemir, Pervin Karli
doaj   +1 more source

Clinical aspects of embryo implantation: from the perspective of tissue perfusion.

, 2006
Hypothesis: Pelvic perfusion is the pivotal factor for the outcome of in vitro fertilisation (IVF) treatment once clinical and embryological variables are controlled for their effect.;Demonstration of Hypothesis: In a series of three studies, the ...
Ozturk, O., Ozturk, Ozkan
core