Results 71 to 80 of about 31,608 (289)

Cleavage-stage or blastocyst-stage embryo biopsy has no impact on growth and health in children up to 2 years of age

Reproductive Biology and Endocrinology, 2023
Background Studies show conflicting results on neonatal outcomes following embryo biopsy for PGT, primarily due to small sample sizes and/or heterogeneity in the timing of embryo biopsy (day 3; EBD3 or day 5/6; EBD5) and type of embryo transfer.
Florence Belva, Fiskani Kondowe, Anick De Vos, Kathelijn Keymolen, Andrea Buysse, Frederik Hes, Veerle Berckmoes, Pieter Verdyck, Willem Verpoest, Martine De Rycke   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fertility and pregnancy outcomes following fresh versus frozen-thawed embryo transfer in assisted reproductive technology [PDF]

, 2019
Background and aims: Assisted reproductive technology has provided great hope for millions of infertile couples. In recent years, frozen-thawed embryo transfer has no longer been merely an add-on to the conventional fresh embryo transfer.
Li, Zhuoyang
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Machine learning prediction of clinical pregnancy in endometriosis patients following fresh IVF/ICSI-ET

European Journal of Medical Research
Background Fresh embryo transfer reduces waiting time and minimizes embryo cryodamage for endometriosis (EM) patients. The current prediction models for fresh embryo transfer outcomes in EM primarily rely on logistic regression, with limited application ...
Xiaoju Wan, Min Yu, Xingwu Wu, Zhihui Huang, Jun Tan   +4 more
doaj   +1 more source

Birthweight difference of singletons conceived through in vitro fertilization with frozen versus fresh embryo transfer: An analysis of 5406 embryo transfers in a retrospective study 2013-2018

, 2020
International audienceINTRODUCTION: Perinatal risks after frozen embro transfer (FET) have been reassuring but some authors suggest that birthweights are higher after FET than after fresh embryo transfer (ET).
Garlantezec, Ronan, Laval, Maude, Guivarc'H-Levêque, Anne   +2 more
core   +1 more source

A Nonsurgical Embryo Transfer Technique for Fresh and Cultured Blastocysts in Rats

Journal of the American Association for Laboratory Animal Science, 2020
The use of a nonsurgical embryo transfer technique in rodents eliminates the potential pain, distress, and health complications that may result from a surgical procedure and as such, represents a refinement in rodent assisted reproductive techniques. A nonsurgical technique has not been previously developed for use with rat embryos.
Barbara J, Stone, Kendra H, Steele, Hongsheng, Men, Sarah J, Srodulski, Elizabeth C, Bryda, Angelika, Fath-Goodin   +5 more
openaire   +3 more sources

Combined fresh and frozen embryo transfer resulting in a twin delivery [PDF]

Human Reproduction, 1998
We report the delivery of non-identical twins resulting from the combined transfer of one fresh and one frozen embryo to a 31 year old patient. To our knowledge, this is the first reported case where both a fresh and a frozen embryo implanted in the same cycle led to non-identical twins.
N, Abusheikha, S, Marcus, F, Akagbosu, S, Avery, P, Brinsden   +4 more
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source