Results 41 to 50 of about 310,394 (295)

Microstructure and mechanical properties of diffusion bonded joints of high-entropy alloy Al5(HfNbTiZr)95 and TC4 titanium alloy

Journal of Materials Research and Technology, 2021
TC4 (Ti–6Al–4V) titanium alloy and Al5(HfNbTiZr)95 refractory high-entropy alloy were successfully diffusion bonded at a temperature range of 800–1000 °C for 60 min under 5 MPa.
Yu Peng, Jinglong Li, Junmiao Shi, Shiwei Li, Jiangtao Xiong   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Performance of two different constitutive models and microstructural evolution of GH4169 superalloy

Mathematical Biosciences and Engineering, 2019
The hot compression tests of GH4169 superalloy were performed in the deformation temperature range of 970 to 1150 ℃ and at the strain rate range of 0.001 to 10 s−1. The flow stress is dependent on temperature and strain rate.
Xiawei Yang, Wenya Li, Yaxin Xu, Xiurong Dong, Kaiwei Hu, Yangfan Zou   +5 more
doaj   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Influence of Chemical Heterogeneity and Third Body on Adhesive Strength: Experiment and Simulation

Frontiers in Mechanical Engineering, 2021
We investigate experimentally and numerically the influence of chemical heterogeneity and of third-body particles on adhesive contact. Chemical heterogeneity is generated by chemical treatment of the contacting bodies changing locally the surface energy.
Iakov A. Lyashenko, Iakov A. Lyashenko, Qiang Li, Valentin L. Popov, Valentin L. Popov   +4 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Finite element modelling for temperature, stresses and strains calculation in linear friction welding of TB9 titanium alloy

Journal of Materials Research and Technology, 2019
In the present paper, finite element method (FEM) simulation of linear friction welding (LFW) TB9 titanium alloy was carried out using ABAQUS software.
Xiawei Yang, Wenya Li, Ying Fu, Qing Ye, Yaxin Xu, Xiurong Dong, Kaiwei Hu, Yangfan Zou   +7 more
doaj   +1 more source

The Case of a 28‐Year‐Old Woman With Medically Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present the case of a 28‐year‐old right‐handed woman with medically refractory focal epilepsy. Her seizure semiology and electroencephalography (EEG) indicated a seizure onset zone in the right central‐parietal area. However, both MRI and PET scans were unremarkable, showing no focal lesions or areas of altered metabolism.
Rishi Sharma, Ilo Leppik, Thomas Henry, Thaddeus Walczak, Sima Patel, Robert McGovern   +5 more
wiley   +1 more source

Friction in Adhesive Contact Between a Rough Hard Indenter and Smooth Soft Elastomer Layer

Machines
The friction between a hard steel indenter and a soft elastomer is studied experimentally. To investigate the influence of roughness, a series of experiments was conducted utilizing an indenter with varying degrees of surface roughness. There is a strong
Iakov A. Lyashenko, Thao H. Pham, Valentin L. Popov   +2 more
doaj   +1 more source