Journal of Diabetes Investigation, EarlyView.Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang +5 more
wiley +1 more source
A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A [PDF]
, 1997 Xi He +5 more
openalex +1 more source
Wingless Capture by Frizzled and Frizzled2 in Drosophila Embryos
Developmental Biology, 2001 A variety of factors could influence how far developmental signals spread. For example, the Patched receptor limits the range of its ligand Hedgehog. Somehow, the Frizzled2 receptor has the opposite effect on its ligand. Increasing the level of Frizzled2 stabilizes Wingless and thus extends the Wingless gradient in Drosophila wing imaginal disks.
Lecourtois, Magalie +3 more
openaire +4 more sources
Periodontology 2000, EarlyView.Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi +4 more
wiley +1 more source
Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner. [PDF]
, 2019 Heterogeneous prostatic carcinoma-associated fibroblasts (CAF) contribute to tumor progression and resistance to androgen signaling deprivation therapy (ADT).
Agarwal, Priyanka +14 more
core +1 more source
Insulin resistance is associated with Sfrp5 in obstructive sleep apnea
Brazilian Journal of Otorhinolaryngology, 2019 Introduction: Obstructive sleep apnea, a common disease, is usually complicated by insulin resistance and type 2 diabetes mellitus. Adipokine is considered to play an important role in the development of insulin resistance and type 2 diabetes mellitus in
Shibo Sun +5 more
doaj
Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling [PDF]
, 1999 Anna Bafico +5 more
openalex +1 more source
OncoTarget, 2016 Sox9, an SRY-related HMG box transcription factor, is a progenitor/precursor cell marker of the liver expressed during embryogenesis and following liver injury. In this study, we investigated the role of Sox9 and its molecular mechanism with reference to
C. Leung +6 more
semanticscholar +1 more source
Inflammation and mechanical force‐induced bone remodeling
Periodontology 2000, EarlyView.Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon +6 more
wiley +1 more source
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. [PDF]
, 1996 Hitoshi Sawa +2 more
openalex +1 more source