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Untangling Frizzled functions

The FASEB Journal, 2022
Wnt signaling is a complex network of cellular signals with multiple downstream pathways regulated by signaling complexes comprised of combinations of the 19 Wnt ligands, 10 Frizzled (FZD) receptors, various co‐receptors and Dishevelled (DVL) second messengers.
Katie Hollis, Bart Williams
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Structure-function analysis of Frizzleds

Cellular Signalling, 2006
Frizzleds, cell surface receptors that mediate the actions of Wnt ligands on early development, are heptahelical (based upon hydropathy analysis) and couple to heterotrimeric G proteins. The primary structure of all ten mammalian Frizzleds display many landmarks observed in virtually all G protein-coupled receptors, including an exofacial N-terminus ...
Hsien-yu, Wang   +2 more
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