Cancer chemoprevention through Frizzled receptors and EMT [PDF]
Discover Oncology, 2021 Frizzled (FZD) transmembrane receptors are well known for their role in β-catenin signaling and development and now understanding of their role in the context of cancer is growing.
K. Sompel +3 more
doaj +6 more sources
Frizzled receptors: gatekeepers of Wnt signaling in development and disease [PDF]
Frontiers in Cell and Developmental BiologyFrizzled (FZD) receptors are a subset of G-protein-coupled receptors (GPCRs), the largest class of human cell surface receptors and a major target of FDA-approved drugs. Activated by Wnt ligands, FZDs regulate key cellular processes such as proliferation,
Dalia Martinez-Marin +3 more
doaj +6 more sources
Non-Coding RNA and Frizzled Receptors in Cancer [PDF]
Frontiers in Molecular Biosciences, 2021 Frizzled receptors have been long recognized for their role in Wnt/β-catenin signaling, a pathway known for its tumorigenic effects. More recent studies of frizzled receptors include efforts to understand non-coding RNA (ncRNA) regulation of these ...
Alex J. Smith +3 more
doaj +5 more sources
Frizzled receptors in melanomagenesis: From molecular interactions to target identification [PDF]
Frontiers in Oncology, 2022 Frizzled (FZD) proteins are receptors for the WNT family ligands. Inherited human diseases and genetic experiments using knockout mice have revealed a central role of FZDs in multiple aspects of embryonic development and tissue homeostasis.
Sheikh A. Umar +4 more
doaj +4 more sources
Frizzled receptors signal through G proteins. [PDF]
Cell Signal, 2013 Frizzled receptors have long been thought to couple to G proteins but biochemical evidence supporting such an interaction has been lacking. Here we expressed mammalian Wnt-Frizzled fusion proteins in Saccharomyces cerevisiae and tested the receptors' ability to activate the yeast mitogen-activated protein kinase (MAPK) pathway via heterotrimeric G ...
Nichols AS +4 more
europepmc +5 more sources
Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive [PDF]
Toxins, 2020 Toxin B (TcdB) produced by Clostridioides difficile is a main pathogenicity factor that affects a variety of different cell types within the colonic mucosa. TcdB is known to utilize frizzled-1,2,7 and chondroitin sulfate proteoglycan-4 (CSPG4) as protein
Daniel Henkel +5 more
doaj +2 more sources
Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. [PDF]
PLoS ONE, 2012 BackgroundWnt proteins are a large family of molecules that are critically involved in multiple central nervous system (CNS) developmental processes.
Pau Gonzalez +4 more
doaj +2 more sources
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein-Coupled Receptors. [PDF]
Pharmacol Res PerspectABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Hutchings CJ +6 more
europepmc +2 more sources
Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET [PDF]
CellsUpon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD1–10), a wide variety of cellular Wnt signaling responses can be elicited, the selectivity of which depends on the ...
Janine Wesslowski +4 more
doaj +2 more sources
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers. [PDF]
Acta Pharmacol SinLiu HY +13 more
europepmc +3 more sources