Results 1 to 10 of about 560 (150)
Cancer chemoprevention through Frizzled receptors and EMT [PDF]
Discover Oncology, 2021 Frizzled (FZD) transmembrane receptors are well known for their role in β-catenin signaling and development and now understanding of their role in the context of cancer is growing.
K. Sompel +3 more
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Role of the
Neural Development, 2009 Background The Wnt signaling pathway regulates several fundamental developmental processes and recently has been shown to be involved in different aspects of synaptic differentiation and plasticity.
Alvarez Alejandra R +4 more
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Non-Coding RNA and Frizzled Receptors in Cancer [PDF]
Frontiers in Molecular Biosciences, 2021 Frizzled receptors have been long recognized for their role in Wnt/β-catenin signaling, a pathway known for its tumorigenic effects. More recent studies of frizzled receptors include efforts to understand non-coding RNA (ncRNA) regulation of these ...
Alex J. Smith +3 more
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Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats. [PDF]
PLoS ONE, 2012 BackgroundWnt proteins are a large family of molecules that are critically involved in multiple central nervous system (CNS) developmental processes.
Pau Gonzalez +4 more
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Deregulation of Frizzled Receptors in Hepatocellular Carcinoma [PDF]
International Journal of Molecular Sciences, 2018 G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a “cancer driver”. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression.
K.K. Chan, Regina Cheuk‐Lam Lo
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Signaling of human frizzled receptors to the mating pathway in yeast. [PDF]
PLoS ONE, 2007 Frizzled receptors have seven membrane-spanning helices and are considered as atypical G protein-coupled receptors (GPCRs). The mating response of the yeast Saccharomyces cerevisiae is mediated by a GPCR signaling system and this model organism has been ...
Dietmar Dirnberger, Klaus Seuwen
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Pathway Specificity by the Bifunctional Receptor Frizzled Is Determined by Affinity for Wingless [PDF]
Molecular Cell, 2000 The Frizzled (Fz) protein in Drosophila is a bifunctional receptor that acts through a GTPase pathway in planar polarity signaling and as a receptor for Wingless (Wg) using the canonical Wnt pathway. We found that the ligand-binding domain (CRD) of Fz has an approximately 10-fold lower affinity for Wg than the CRD of DFz2, a Wg receptor without ...
E RULIFSON
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Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants [PDF]
Stem Cells International, 2016 The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors.
Katharina Nothelfer +7 more
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The G protein-coupled receptor identity of the frizzled proteins [PDF]
Cell Communication and Signaling, 2009 Receptors of the Frizzled family initiate Wnt ligand-dependent signal transduction cascades controlling multiple steps in organism development and are highly conserved in animal evolution. Misactivation of the Wnt/Frizzled signaling underlies many cases of cancerogenesis.
Vladimir L. Katanaev, Silke Buestorf
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The Frizzled family: receptors for multiple signal transduction pathways. [PDF]
Genome biology, 2004 Frizzled genes encode integral membrane proteins that function in multiple signal transduction pathways. They have been identified in diverse animals, from sponges to humans. The family is defined by conserved structural features, including seven hydrophobic domains and a cysteine-rich ligand-binding domain. Frizzled proteins are receptors for secreted
Hui‐Chuan Huang, Peter S. Klein
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