Results 91 to 100 of about 19,373 (224)

Growth‐regulating proteins differ between British seawater fish species, shedding light on their ecological adaptations

Journal of Fish Biology, EarlyView.
Abstract Wnt proteins are a family of molecules that help control how cells grow, develop and communicate – processes that are fundamental to the development and health of all animals. Although Wnt pathways have been studied extensively in model species, very little is known about how they operate in marine fish.
Angeliki Maravelia, Soniya Malik, Clare Murcott, Ioannis Batzakas, Paraskevi Goggolidou   +4 more
wiley   +1 more source

A novel, PCP‐dependent tissue organising principle coordinating morphogenesis between embryonic skin epidermal layers

Journal of Anatomy, EarlyView.
‘Outside‐in’ expression of Fz6 across multiple layers of mouse embryo epidermis is connected to Fz6 asymmetry in the basal layer plane. Fz6 loss‐of‐function correlated with failure to: coordinate axial bias of cell long axis orientation across epidermal layers, switch axial cell long axis orientation during suprabasal layer development and establish ...
C. J. Formstone
wiley   +1 more source

The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate

Neural Development, 2008
Background Secreted frizzled related proteins (SFRPs) are multifunctional modulators of Wnt and BMP (Bone Morphogenetic Protein) signalling necessary for the development of most organs and the homeostasis of different adult tissues.
Esteve Pilar, Lopez-Rios Javier, Ruiz Jose, Bovolenta Paola   +3 more
doaj   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

The evolution and expression of panarthropod frizzled genes

Frontiers in Ecology and Evolution, 2015
Wnt signaling regulates many important processes during metazoan development. It has been shown that Wnt ligands represent an ancient and diverse family of proteins that likely function in complex signaling landscapes to induce target cells via receptors
Ralf eJanssen, Anna eSchönauer, Melanie eWeber, Melanie eWeber, Natascha eTuretzek, Matthias eHogvall, Georgina E. Goss, Neel H. Patel, Alistair Peter McGregor, Maarten eHilbrant, Maarten eHilbrant   +10 more
doaj   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors

BMC Evolutionary Biology, 2008
Background G protein-coupled receptors (GPCRs) are one of the largest families of genes in mammals. Branchiostoma floridae (amphioxus) is one of the species most closely related species to vertebrates.
Schiöth Helgi B, Fredriksson Robert, Nordström Karl JV   +2 more
doaj   +1 more source

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination [PDF]

, 2022
Naotaka Tsutsumi, Sun‐Hee Hwang, Simon Hansen, Deepa Waghray, Nan Wang, Yi Miao, Caleb R. Glassman, Nathanael A. Caveney, Kevin M. Jude, Claudia Y. Janda, Rami N. Hannoush, K. Christopher García   +11 more
openalex   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface. [PDF]

EMBO Rep, 2023
Li M, Zheng J, Luo D, Xu K, Sheng R, MacDonald BT, He X, Zhang X.   +7 more
europepmc   +1 more source