Results 121 to 130 of about 19,373 (224)

The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5 [PDF]

, 2019
Zakia A. Abdelhamed, Dina Abdelmottaleb, Mohammed E. El‐Asrag, Subaashini Natarajan, Gabrielle Wheway, Chris F. Inglehearn, Carmel Toomes, Colin A. Johnson   +7 more
openalex   +1 more source

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

Cell Reports
Summary: The G protein-coupled receptors of the Frizzled (FZD) family, in particular FZD1,2,7, are receptors that are exploited by Clostridioides difficile toxin B (TcdB), the major virulence factor responsible for pathogenesis associated with ...
Julia Kinsolving, Julien Bous, Pawel Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, Geoffrey Masuyer, Yuankai Wang, Pål Stenmark, Min Dong, Gunnar Schulte   +10 more
doaj   +1 more source

Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells [PDF]

, 2007
Kestutis Planutis, Marina Planutiene, Mary Pat Moyer, Anthony V. Nguyen, Cherlyn A Pérez, Randall F. Holcombe   +5 more
openalex   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, Volume 10, Issue 2, 22 January 2026.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Osteochondrosis in horses: An overview of genetic and other factors

Equine Veterinary Journal, Volume 58, Issue 1, Page 6-19, January 2026.
Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez, Pablo J. Marín‐García, M. Lola Llobat   +2 more
wiley   +1 more source

Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model [PDF]

, 2022
Lukas Grätz, Joanna J. Sajkowska‐Kozielewicz, Janine Wesslowski, Katja Petzold, Gary Davidson, Gunnar Schulte, Paweł Kozielewicz   +6 more
openalex   +1 more source

Development of the neurohypophysis: A major neuroendocrine interface

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract The neurohypophysis is a major central neuroendocrine interface regulating reproductive functions and water homeostasis. Distinct neurovascular cell types interact via evolutionarily conserved signaling molecules in the developing neurohypophysis, providing a model system for studying principles in neuroendocrine interface morphogenesis.
Athul R. Ramesh, Naveen Nedunchezhian, Md Hasan Ali, Sebastian Pęcherz, Natalia Kowalewska, Savani Anbalagan   +5 more
wiley   +1 more source

Perlecan, CollagenXVIII, and Agrin Expression in Normo‐, Hypo‐, and Aganglionic Segments in Hirschsprung's Disease

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
The secretory heparan sulphate proteoglycans perlecan, agrin, collagen18A1 are expressed in the periganglionic sheath of enteric ganglia in resectates of Hirschsprung's disease patients and non‐Hirschsprung controls. ABSTRACT Background Secretory heparan sulphate proteoglycans (HSPGs) interact with various morphogens, growth factors, and signaling ...
Nico van den Beld, Melina Fischer, Melanie Scharr, Simon Scherer, Rudi Beschorner, Bernhard Hirt, Peter H. Neckel   +6 more
wiley   +1 more source