Results 121 to 130 of about 18,461 (227)
PLoS Biology, 2004 The Frizzled (Fz; called here Fz1) and Fz2 receptors have distinct signaling specificities activating either the canonical Wnt/beta-catenin pathway or Fz/planar cell polarity (PCP) signaling in Drosophila.
Jun Wu, Thomas J Klein, Marek Mlodzik
doaj +1 more source
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression [PDF]
, 2006 Ju‐Suk Nam +4 more
openalex +1 more source
The Potential Role of Egg‐Derived Xeno‐miRs in Chemotherapy Response: An In Silico Approach
Food Science &Nutrition, Volume 13, Issue 6, June 2025.Dietary microRNAs (Xeno‐miRs), especially those homologous to human miRNAs found in animal‐based foods, may influence chemotherapy responses across cancer types. This study highlights the underexplored potential of human homolog egg‐derived Xeno‐miRs as biomarkers and therapeutic targets.
Berkcan Doğan
wiley +1 more source
Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer
MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.This review explores integrated approach of nanotechnology to breast cancer diagnosis and treatment. We highlight imaging techniques for tumor detection and biomarker analysis in biological samples for early diagnosis. Advanced therapies, including targeted drug delivery and antibody‐drug conjugates, enable precise medication transport to cancer cells,
Mohan Liu +7 more
wiley +1 more source
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
Cell Reports, 2018 Summary: The structural and functional plasticity of synapses is critical for learning and memory. Long-term potentiation (LTP) induction promotes spine growth and AMPAR accumulation at excitatory synapses, leading to increased synaptic strength ...
Faye McLeod +10 more
doaj
Phosphatase Dysregulation in Cancer: Signaling Pathways and Therapeutic Opportunities
MedComm – Oncology, Volume 4, Issue 2, June 2025.Schematic depiction of the role of phosphatases in cancer, highlighting their involvement in proliferation, exosome secretion, and immunosuppression. The SHP2 crystal structure (PDB:5EHR) is shown as the representative phosphatase. ABSTRACT Phosphatases are increasingly recognized as critical regulators of cancer biology, with important roles in both ...
Maryam Jama +2 more
wiley +1 more source
MultiPassMerger: Automated data processing for multipass cyclic ion mobility HDX‐MS
Protein Science, Volume 34, Issue 6, June 2025.Abstract Hydrogen/deuterium exchange‐mass spectrometry (HDX‐MS) is a powerful tool for studying protein structure and dynamics. As a bottom‐up LC‐MS technique, its success largely depends on peptide identifications made by peptide mapping prior to HDX measurements.
Vanessa Duerr +2 more
wiley +1 more source
Multi‐Omic Analysis of Glutamate Excitotoxicity in Primary Neuronal Cultures
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.Our study on rat neuron cells found 250 μM glutamate to be toxic, causing neuron death. We identified genes in pathways linked to apoptosis, neuron plasticity, and cell signaling, along with proteins regulating the cell cycle and tumor proliferation.
Jennifer H. Nguyen +13 more
wiley +1 more source
Sea anemone Frizzled receptors play partially redundant roles in oral-aboral axis patterning.
Development, 2022 Niedermoser I +2 more
europepmc +1 more source