Results 11 to 20 of about 19,373 (224)
Signaling of human frizzled receptors to the mating pathway in yeast. [PDF]
PLoS ONE, 2007 Frizzled receptors have seven membrane-spanning helices and are considered as atypical G protein-coupled receptors (GPCRs). The mating response of the yeast Saccharomyces cerevisiae is mediated by a GPCR signaling system and this model organism has been ...
Dietmar Dirnberger, Klaus Seuwen
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Role of the
Neural Development, 2009 Background The Wnt signaling pathway regulates several fundamental developmental processes and recently has been shown to be involved in different aspects of synaptic differentiation and plasticity.
Alvarez Alejandra R +4 more
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FZD6 (Frizzled class receptor 6) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019 Frizzled-6 (FZD6) gene, located on chromosome 8 (8q22.3-q23.1), encodes a seven-transmembrane-spanning protein belonging to the frizzled’ family of receptors for the Wnt (Wingless/Int-1) ligands. FZD6 is classified as G-protein-coupling receptor with a prevalent role in the non-canonical Wnt signaling pathway, a series of steps that affect the way ...
Alessandro Beghini, Giovanni Postorino
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Non‐conventional Frizzled ligands and Wnt receptors [PDF]
Development, Growth & Differentiation, 2008 The Wnt family of secreted signaling factors plays numerous roles in embryonic development and in stem cell biology. In the adult, Wnt signaling is involved in tissue homeostasis and mutations that lead to the overexpression of Wnt can be linked to cancer. Wnt signaling is transduced intracellularly by the Frizzled (Fzd) family of receptors.
Marijke Hendrickx, Luc Leyns
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The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity [PDF]
Journal of Cell Science, 2015 Cranial neural crest cells (CNC) are a transient population of “stem cells” that originate at the border of the neural plate and the epidermis and migrate ventrally to contribute to most of the facial structures including bones, cartilage, muscles and ganglia. ADAM13 is a cell surface metalloprotease that is essential for CNC migration.
Genevieve Abbruzzese +6 more
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Frizzled Receptors in Development and Disease. [PDF]
Curr Top Dev Biol, 2016 Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr, Vangl, and a small number of additional membrane and membrane-associated proteins, they also play a central role in tissue polarity/planar cell polarity (PCP) signaling ...
Wang Y, Chang H, Rattner A, Nathans J.
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Deregulation of Frizzled Receptors in Hepatocellular Carcinoma. [PDF]
Int J Mol Sci, 2018 G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a “cancer driver”. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression.
Chan KK, Lo RC.
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Iloprost requires the Frizzled-9 receptor to prevent lung cancer [PDF]
iScience, 2022 Prevention of premalignant lesion progression is a promising approach to reducing lung cancer burden in high-risk populations. Substantial preclinical and clinical evidence has demonstrated efficacy of the prostacyclin analogue iloprost for lung cancer chemoprevention.
Kayla Sompel +11 more
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Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of receptors, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners ...
Bryan T. MacDonald, Xi He
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Frizzled Receptors as Potential Therapeutic Targets in Human Cancers. [PDF]
Int J Mol Sci, 2018 Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of ...
Zeng CM, Chen Z, Fu L.
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