Results 11 to 20 of about 18,461 (227)
Frizzled receptors in melanomagenesis: From molecular interactions to target identification [PDF]
Frontiers in Oncology, 2022 Frizzled (FZD) proteins are receptors for the WNT family ligands. Inherited human diseases and genetic experiments using knockout mice have revealed a central role of FZDs in multiple aspects of embryonic development and tissue homeostasis.
Sheikh A. Umar +4 more
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Frizzled receptors: gatekeepers of Wnt signaling in development and disease [PDF]
Frontiers in Cell and Developmental BiologyFrizzled (FZD) receptors are a subset of G-protein-coupled receptors (GPCRs), the largest class of human cell surface receptors and a major target of FDA-approved drugs. Activated by Wnt ligands, FZDs regulate key cellular processes such as proliferation,
Dalia Martinez-Marin +3 more
doaj +3 more sources
Frizzled Receptors in Development and Disease [PDF]
Curr Top Dev Biol, 2016 Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr, Vangl, and a small number of additional membrane and membrane-associated proteins, they also play a central role in tissue polarity/planar cell polarity (PCP) signaling ...
Amir Rattner +3 more
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Frizzled receptors signal through G proteins [PDF]
Cellular Signalling, 2013 Frizzled receptors have long been thought to couple to G proteins but biochemical evidence supporting such an interaction has been lacking. Here we expressed mammalian Wnt-Frizzled fusion proteins in Saccharomyces cerevisiae and tested the receptors' ability to activate the yeast mitogen-activated protein kinase (MAPK) pathway via heterotrimeric G ...
Thomas J. Baranski +4 more
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Frizzled Receptors as Potential Therapeutic Targets in Human Cancers [PDF]
International Journal of Molecular Sciences, 2018 Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of ...
Chui-Mian Zeng, Zhe Chen, Li Fu
openaire +4 more sources
Signaling Specificity by Frizzled Receptors in Drosophila [PDF]
Science, 2000 Wnt-Frizzled (Fz) signaling pathways play recurring important roles during the development and homeostasis of vertebrates and invertebrates. Fz receptors can signal through β-catenin–dependent and –independent pathways. In Drosophila , Fz and Fz2 are redundant receptors for Wg.
Michael Boutros +3 more
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The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity [PDF]
Journal of Cell Science, 2015 Cranial neural crest cells (CNC) are a transient population of “stem cells” that originate at the border of the neural plate and the epidermis and migrate ventrally to contribute to most of the facial structures including bones, cartilage, muscles and ganglia. ADAM13 is a cell surface metalloprotease that is essential for CNC migration.
Genevieve Abbruzzese +6 more
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Frizzleds: new members of the superfamily of G-protein-coupled receptors [PDF]
Frontiers in Bioscience, 2004 The superfamily of membrane receptors that signal via heterotrimeric G-proteins includes more than 1500 members, classified into five basic groups, representing about 5-10% of the human genome. These G-protein-coupled receptors operate through a comparatively smaller group of heterotrimeric G-protein family of approximately 20 members, each displaying ...
Coopersmith M Craig
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Receptor endocytosis: Frizzled joins the ubiquitin club [PDF]
The EMBO Journal, 2010 Wnt/β‐catenin signalling is initiated by binding of secreted Wnt ligands to Frizzled and LRP5/6/Arrow co‐receptors. A new study in this issue of The EMBO Journal provides compelling evidence that the level of cell surface Frizzled is controlled by a cycle of mono‐ubiquitylation–deubiquitylation, the latter being mediated by the deubiquitylating ...
Ken M. Cadigan
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Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET [PDF]
CellsUpon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD1–10), a wide variety of cellular Wnt signaling responses can be elicited, the selectivity of which depends on the ...
Janine Wesslowski +4 more
doaj +2 more sources