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CD44 is a macrophage receptor for TcdB from <i>Clostridioides difficile</i> that <i>via</i> its lysine-158 succinylation contributes to inflammation. [PDF]

Gut Microbes
Chen Z, Zhang W, Wang D, Luo R, Yao Y, Tao X, Li L, Pan Q, Sun X.   +8 more
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frizzled 5 mutant zebrafish are genetically sensitised to developing microphthalmia and coloboma.

Dis Model Mech
Monfries C, Carter S, Ataliotis P, Bseisu A, Shaikh M, Hernández-Bejarano M, Fourteia M, Maftei MI, Young RM, Wilson SW, Gestri G, Cavodeassi F.   +11 more
europepmc   +1 more source

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Non‐conventional Frizzled ligands and Wnt receptors

Development, Growth & Differentiation, 2008
The Wnt family of secreted signaling factors plays numerous roles in embryonic development and in stem cell biology. In the adult, Wnt signaling is involved in tissue homeostasis and mutations that lead to the overexpression of Wnt can be linked to cancer. Wnt signaling is transduced intracellularly by the Frizzled (Fzd) family of receptors.
Hendrickx, Marijke, Leyns, Luc
openaire   +4 more sources

Expression profile of frizzled receptors in human medulloblastomas

Journal of Neuro-Oncology, 2011
Secreted WNT proteins signal through ten receptors of the frizzled (FZD) family. Because of the relevance of the WNT/β-catenin (CTNNB1) signaling pathway in medulloblastomas (MBs), we investigated the expression of all ten members of the FZD gene family (FZD1-10) in 17 human MBs, four MB cell lines and in normal human cerebellum, using real-time PCR ...
Miriam Figus, Carlo L. Solero, Bianca Pollo, Gaetano Finocchiaro, Rosina Paterra, Francesca Menghi, Luca Massimi, Emanuela Maderna, Ettore Salsano   +8 more
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The emerging understanding of Frizzled receptors

FEBS Letters
The Wnt signaling pathway is a huge network governing development and homeostasis, dysregulation of which is associated with a myriad of human diseases. The Frizzled receptor (FZD) family comprises receptors for Wnt ligands, which indispensably mediate Wnt signaling jointly with a variety of co‐receptors.
Shaoqin Zheng, Ren Sheng
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The Frizzled family of unconventional G-protein-coupled receptors

Trends in Pharmacological Sciences, 2007
The Frizzled (FZD) family of receptors is critically involved in embryogenesis, and there is substantial evidence that members of this family also regulate tissue homeostasis in many different organs in the adult. FZD receptors have seven transmembrane-spanning domains and are activated by the WNT family of lipoglycoproteins. Many aspects of FZD signal
Gunnar Schulte, Vítězslav Bryja, Vítězslav Bryja   +2 more
openaire   +3 more sources

Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors

Trends in Biochemical Sciences, 2018
Class Frizzled G protein-coupled receptors (GPCRs), which includes the Smoothened receptor (SMO) and 10 Frizzled receptors (FZDs), are responsible for mediating fundamental signaling in embryonic development and tissue homeostasis. Dysregulation of these receptors can lead to cancer.
Fei Xu, Xianjun Zhang, Shaowei Dong, Shaowei Dong   +3 more
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Crystal structure of the Frizzled 4 receptor in a ligand-free state

Nature, 2018
Frizzled receptors (FZDs) are class-F G-protein-coupled receptors (GPCRs) that function in Wnt signalling and are essential for developing and adult organisms1,2. As central mediators in this complex signalling pathway, FZDs serve as gatekeeping proteins both for drug intervention and for the development of probes in basic and in therapeutic research ...
Fei Xu, Suwen Zhao, Lu Yang, Laurence J. Miller, Gye Won Han, Karsten Melcher, Kaleeckal G. Harikumar, Wenqing Shui, Shifan Yang, Parker W. de Waal, Yiran Wu, Yu Guo, Mengchen Pu, Yuxiang Chen, Ting-Hai Xu, Shaowei Dong, Kelly Suino-Powell, Zachary J. DeBruine, Yuanzheng He, Bingjie Zhang, Vsevolod Katritch, Vsevolod Katritch, H. Eric Xu, H. Eric Xu, Raymond C. Stevens, Petr Popov, Petr Popov, Saheem A. Zaidi   +27 more
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Identification and characterization of the epithelial polarity receptor ”Frizzled” in Hydra vulgaris

Development Genes and Evolution, 2000
The Wnt signaling pathway plays an important role in the specification of cell patterning during development in many species. Here we report the isolation and characterization of a putative Wnt receptor, Frizzled, in Hydra vulgaris. Analysis of the amino acid sequence of Frizzled in hydra reveals that this receptor contains many strong sequence ...
Michael P. Sarras, M. J. Werle, S. Minobe, Kaiyin Fei, Li Yan   +4 more
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