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The emerging understanding of Frizzled receptors
FEBS LettersThe Wnt signaling pathway is a huge network governing development and homeostasis, dysregulation of which is associated with a myriad of human diseases. The Frizzled receptor (FZD) family comprises receptors for Wnt ligands, which indispensably mediate Wnt signaling jointly with a variety of co‐receptors.
Shaoqin Zheng, Ren Sheng
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Signaling Specificity by Frizzled Receptors in Drosophila
Science, 2000Wnt-Frizzled (Fz) signaling pathways play recurring important roles during the development and homeostasis of vertebrates and invertebrates. Fz receptors can signal through β-catenin–dependent and –independent pathways. In Drosophila , Fz and Fz2 are redundant receptors for Wg.
M, Boutros +3 more
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The Frizzled family of unconventional G-protein-coupled receptors
Trends in Pharmacological Sciences, 2007The Frizzled (FZD) family of receptors is critically involved in embryogenesis, and there is substantial evidence that members of this family also regulate tissue homeostasis in many different organs in the adult. FZD receptors have seven transmembrane-spanning domains and are activated by the WNT family of lipoglycoproteins. Many aspects of FZD signal
Gunnar, Schulte, Vítezslav, Bryja
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Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors
Trends in Biochemical Sciences, 2018Class Frizzled G protein-coupled receptors (GPCRs), which includes the Smoothened receptor (SMO) and 10 Frizzled receptors (FZDs), are responsible for mediating fundamental signaling in embryonic development and tissue homeostasis. Dysregulation of these receptors can lead to cancer.
Xianjun, Zhang, Shaowei, Dong, Fei, Xu
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Trimeric G protein-dependent signaling by Frizzled receptors in animal development
Frontiers in Bioscience, 2008Receptors of the Frizzled family transduce important signals during animal development and are conserved from sponges to humans. Frizzled receptors belong to the superfamily of G protein-coupled receptors (GPCRs), but until recently were considered G protein-independent in their signaling.
Diane, Egger-Adam, Vladimir L, Katanaev
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Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma
Gastroenterology, 2004The molecular pathogenesis of human hepatocellular carcinoma (HCC) is understood poorly. In some tumors, activation of the Wnt/beta-catenin pathway as a result of beta-catenin gene mutations has been found. However, in many other HCCs, activation of the Wnt/beta-catenin pathway has been shown in the absence of such mutations.We previously have ...
Philippe, Merle +8 more
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The mouse frizzled 8 receptor is expressed in anterior organizer tissues
Gene Expression Patterns, 2004Wnt signaling has been shown to be important for axis formation in vertebrates. However, no Wnt ligand or receptor has been shown to be specifically expressed in all the organizer tissues in the mouse embryo. Here we report that the mouse frizzled 8 (mfz8) gene, a Wnt receptor, is expressed in the anterior visceral endoderm (AVE) and the anterior ...
C C, Lu, E J, Robertson, J, Brennan
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Frizzleds: new members of the superfamily of G-protein-coupled receptors
Frontiers in Bioscience, 2004The superfamily of membrane receptors that signal via heterotrimeric G-proteins includes more than 1500 members, classified into five basic groups, representing about 5-10% of the human genome. These G-protein-coupled receptors operate through a comparatively smaller group of heterotrimeric G-protein family of approximately 20 members, each displaying ...
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Synthesis and Frizzled-receptor binding of a WNT5A hairpin-3 peptide
Chemical CommunicationsWe synthesized the three-disulfide crosslinked hairpin-3 from Wnt proteins as a peptide ligand for Frizzled.
Yuanyuan Hei +4 more
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Pioneering Frizzled family receptor structure solved
Nature Reviews Drug Discovery, 2013openaire +1 more source