Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding [PDF]
Proc Natl Acad Sci U S A, 2017 Aaron H. Nile +4 more
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E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors [PDF]
Life Sci AllianceJeroen M. Bugter +7 more
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Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. [PDF]
PLoS ONE, 2012 The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can antagonize Wnt/β-catenin signaling, including the decoy receptors known as secreted frizzled related proteins (SFRPs), which ...
Ismaïl Hendaoui +8 more
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FZD4 (frizzled class receptor 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Fzd4 is a receptor for Wnt proteins, belonging to the frizzled receptors family. Its stimulation can activate both Wnt/β-catenin canonical and Wnt/Ca2+ non canonical pathways. This receptor plays an important role in the development processes, in particular in the retinal vascularization: it binds the Norrin ligand, a Wnt-unrelated growth factor, and ...
A. Beghini, A. Cassaro
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FZD6 (Frizzled class receptor 6) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019 Frizzled-6 (FZD6) gene, located on chromosome 8 (8q22.3-q23.1), encodes a seven-transmembrane-spanning protein belonging to the frizzled’ family of receptors for the Wnt (Wingless/Int-1) ligands. FZD6 is classified as G-protein-coupling receptor with a prevalent role in the non-canonical Wnt signaling pathway, a series of steps that affect the way ...
A. Beghini, G. Postorino
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Residue 6.43 defines receptor function in class F GPCRs
Nature Communications, 2021 The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformational ...
Ainoleena Turku +4 more
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Fatty acid recognition in the Frizzled receptor family [PDF]
Journal of Biological Chemistry, 2019 Wnt signaling regulates physiological processes ranging from cell differentiation to bone formation. Dysregulation of Wnt signaling is linked to several human ailments, including colorectal, pancreatic, and breast cancers. As such, modulation of this pathway has been an attractive strategy for therapeutic development of anticancer agents.
Aaron H. Nile, Rami N. Hannoush
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Unraveling the dysregulation of Frizzled receptors in Alzheimer’s disease: Critical contributor for synapse loss [PDF]
Alzheimers DementNimisha Basavaraju, Reddy Peera Kommaddi
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Toxins, 2020 Toxin B (TcdB) produced by Clostridioides difficile is a main pathogenicity factor that affects a variety of different cell types within the colonic mucosa. TcdB is known to utilize frizzled-1,2,7 and chondroitin sulfate proteoglycan-4 (CSPG4) as protein
Daniel Henkel +5 more
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Functional role of the Frizzled linker domain in the Wnt signaling pathway
Communications Biology, 2022 The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.
Seung-Bum Ko +7 more
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