Results 21 to 30 of about 19,373 (224)
Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells [PDF]
Frontiers in Cellular Neuroscience, 2014 Cumulative evidence indicates that Wnt pathways play crucial and diverse roles to assemble the neuromuscular junction (NMJ), a peripheral synapse characterized by the clustering of acetylcholine receptors (AChR) on postsynaptic densities. The molecular determinants of Wnt effects at the NMJ are still to be fully elucidated.
Evelyn C. Avilés +9 more
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Frizzled receptors in neurons: From growth cones to the synapse
Cytoskeleton, 2012 AbstractThe Wnt signaling pathway has been implicated in several different aspects of neural development and function, including dendrite morphogenesis, axonal growth and guidance, synaptogenesis and synaptic plasticity. Here, we studied several Frizzled Wnt receptors and determined their differential expression during hippocampal development.
Lorena Varela‐Nallar +3 more
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Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. [PDF]
PLoS ONE, 2012 The Wnt/β-catenin pathway controls cell proliferation, death and differentiation. Several families of extracellular proteins can antagonize Wnt/β-catenin signaling, including the decoy receptors known as secreted frizzled related proteins (SFRPs), which ...
Ismaïl Hendaoui +8 more
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FZD4 (frizzled class receptor 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Fzd4 is a receptor for Wnt proteins, belonging to the frizzled receptors family. Its stimulation can activate both Wnt/β-catenin canonical and Wnt/Ca2+ non canonical pathways. This receptor plays an important role in the development processes, in particular in the retinal vascularization: it binds the Norrin ligand, a Wnt-unrelated growth factor, and ...
A. Beghini, A. Cassaro
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Expression analysis of chick Frizzled receptors during spinal cord development [PDF]
Gene Expression Patterns, 2021 Frizzleds (Fzds) are transmembrane receptors that can transduce signals dependent upon binding of Wnts, a large family of secreted glycoproteins homologous to the Drosophila wingless gene. FZDs are critical for a wide variety of normal and pathological developmental processes. In the nervous system, Wnts and Frizzleds play an important role in anterior-
Abdulmajeed Fahad Alrefaei +2 more
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Residue 6.43 defines receptor function in class F GPCRs
Nature Communications, 2021 The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformational ...
Ainoleena Turku +4 more
doaj +1 more source
Frizzled-1 receptor regulates adult hippocampal neurogenesis [PDF]
Molecular Brain, 2016 In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt signaling, which plays a complex role in regulating multiple steps of neurogenesis including maintenance, proliferation and differentiation of progenitor cells and the ...
Mardones, Muriel D. +8 more
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Functional role of the Frizzled linker domain in the Wnt signaling pathway
Communications Biology, 2022 The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.
Seung-Bum Ko +7 more
doaj +1 more source
Fatty acid recognition in the Frizzled receptor family [PDF]
Journal of Biological Chemistry, 2019 Wnt signaling regulates physiological processes ranging from cell differentiation to bone formation. Dysregulation of Wnt signaling is linked to several human ailments, including colorectal, pancreatic, and breast cancers. As such, modulation of this pathway has been an attractive strategy for therapeutic development of anticancer agents.
Aaron H. Nile, Rami N. Hannoush
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