Results 31 to 40 of about 18,461 (227)

Frizzled-1 receptor regulates adult hippocampal neurogenesis [PDF]

Molecular Brain, 2016
In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt signaling, which plays a complex role in regulating multiple steps of neurogenesis including maintenance, proliferation and differentiation of progenitor cells and the ...
Maria I. Behrens, Maria I. Behrens, Gabriela A. Andaur, Manuel Varas-Godoy, Felipe Salech, Lorena Varela-Nallar, Andrés Couve, Muriel D. Mardones, Nibaldo C. Inestrosa, Nibaldo C. Inestrosa, Nibaldo C. Inestrosa, Jenny F. Henriquez   +11 more
openaire   +7 more sources

Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing.

PLoS Biology, 2023
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus.
Francisco Nualart, Manuel Cifuentes, Eder Ramírez, Fernando Martínez, María José Barahona, Luciano Ferrada, Natalia Saldivia, Ernesto R Bongarzone, Bernard Thorens, Katterine Salazar   +9 more
doaj   +1 more source

The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. [PDF]

PLoS ONE, 2012
G protein-coupled receptors (GPCRs) in humans are classified into the five main families named Glutamate, Rhodopsin, Adhesion, Frizzled and Secretin according to the GRAFS classification. Previous results show that these mammalian GRAFS families are well
Arunkumar Krishnan, Markus Sällman Almén, Robert Fredriksson, Helgi B Schiöth   +3 more
doaj   +1 more source

Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/β-catenin signaling

Cell Communication and Signaling, 2005
Background Secreted Frizzled related proteins (SFRPs) are extracellular regulators of Wnt signaling. These proteins contain an N-terminal cysteine rich domain (CRD) highly similar to the CRDs of the Frizzled family of seven-transmembrane proteins that ...
Medina Araceli, Katoh Masaru, Swain Rajeeb, Steinbeisser Herbert   +3 more
doaj   +1 more source

Control of bone formation by the serpentine receptor Frizzled-9 [PDF]

Journal of Cell Biology, 2011
Although Wnt signaling in osteoblasts is of critical importance for the regulation of bone remodeling, it is not yet known which specific Wnt receptors of the Frizzled family are functionally relevant in this process. In this paper, we show that Fzd9 is induced upon osteoblast differentiation and that Fzd9−/− mice display low bone mass caused by ...
Albers, Joachim, Schulze, Jochen, Beil, Frank Timo, Gebauer, Matthias, Baranowsky, Anke, Keller, Johannes, Marshall, Robert P., Wintges, Kristofer, Friedrich, Felix W., Priemel, Matthias, Schilling, Arndt F., Rueger, Johannes M., Cornils, Kerstin, Fehse, Boris, Streichert, Thomas, Sauter, Guido, Jakob, Franz, Insogna, Karl L., Pober, Barbara, Knobeloch, Klaus-Peter, Amling, Michael, Schinke, Thorsten, Francke, Uta   +22 more
openaire   +4 more sources

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

eLife, 2019
Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6.
Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu   +14 more
doaj   +1 more source

Expression of the Frizzled receptors and their co-receptors in calcified human aortic valves [PDF]

Canadian Journal of Physiology and Pharmacology, 2018
The cellular mechanisms that induce calcific aortic stenosis are yet to be unraveled. Wnt signaling is increasingly being considered as a major player in the disease process. However, the presence of Wnt Frizzled (Fzd) receptors and co-receptors LRP5 and 6 in normal and diseased human aortic valves remains to be elucidated.
Siddique, Ateeque, Yu, Bin, Khan, Kashif, Buyting, Ryan, Al-Kindi, Hamood, Alaws, Hossny, Rhéaume, Eric, Tardif, Jean-Claude, Cecere, Renzo, Schwertani, Adel   +9 more
openaire   +3 more sources

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. [PDF]

PLoS Biology, 2006
The Wnts comprise a large class of secreted proteins that control essential developmental processes such as embryonic patterning, cell growth, migration, and differentiation.
Amanda J Mikels, Roel Nusse
doaj   +1 more source

Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene

BMC Evolutionary Biology, 2019
Background Frizzled family members belong to G-protein coupled receptors and encode proteins accountable for cell signal transduction, cell proliferation and cell death. Members of Frizzled receptor family are considered to have critical roles in causing
Suman Seemab, Nashaiman Pervaiz, Rabail Zehra, Saneela Anwar, Yiming Bao, Amir Ali Abbasi   +5 more
doaj   +1 more source

Role of Sfrps in cardiovascular disease

Therapeutic Advances in Chronic Disease, 2020
Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt signaling cascade, and Sfrps interact with their corresponding receptors.
Anqing Huang, Yuli Huang
doaj   +1 more source