Results 31 to 40 of about 19,373 (224)

Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing.

PLoS Biology, 2023
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus.
Francisco Nualart, Manuel Cifuentes, Eder Ramírez, Fernando Martínez, María José Barahona, Luciano Ferrada, Natalia Saldivia, Ernesto R Bongarzone, Bernard Thorens, Katterine Salazar   +9 more
doaj   +1 more source

The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. [PDF]

PLoS ONE, 2012
G protein-coupled receptors (GPCRs) in humans are classified into the five main families named Glutamate, Rhodopsin, Adhesion, Frizzled and Secretin according to the GRAFS classification. Previous results show that these mammalian GRAFS families are well
Arunkumar Krishnan, Markus Sällman Almén, Robert Fredriksson, Helgi B Schiöth   +3 more
doaj   +1 more source

Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/β-catenin signaling

Cell Communication and Signaling, 2005
Background Secreted Frizzled related proteins (SFRPs) are extracellular regulators of Wnt signaling. These proteins contain an N-terminal cysteine rich domain (CRD) highly similar to the CRDs of the Frizzled family of seven-transmembrane proteins that ...
Medina Araceli, Katoh Masaru, Swain Rajeeb, Steinbeisser Herbert   +3 more
doaj   +1 more source

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. [PDF]

PLoS Biology, 2006
The Wnts comprise a large class of secreted proteins that control essential developmental processes such as embryonic patterning, cell growth, migration, and differentiation.
Amanda J Mikels, Roel Nusse
doaj   +1 more source

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

eLife, 2019
Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6.
Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu   +14 more
doaj   +1 more source

FZD5 (frizzled class receptor 5) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019
The Wnt signalling pathways are ways of signalling that transduce signals into cells through cell surface receptors; they are three different type of pathways and all of these are activated by binding a Wnt-protein ligand to a Frizzled family receptor.
openaire   +2 more sources

Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene

BMC Evolutionary Biology, 2019
Background Frizzled family members belong to G-protein coupled receptors and encode proteins accountable for cell signal transduction, cell proliferation and cell death. Members of Frizzled receptor family are considered to have critical roles in causing
Suman Seemab, Nashaiman Pervaiz, Rabail Zehra, Saneela Anwar, Yiming Bao, Amir Ali Abbasi   +5 more
doaj   +1 more source

Role of Sfrps in cardiovascular disease

Therapeutic Advances in Chronic Disease, 2020
Secreted frizzled-related proteins (Sfrps) are a family of secreted proteins that bind extracellularly to Wnt ligands and frizzled receptors. This binding modulates the Wnt signaling cascade, and Sfrps interact with their corresponding receptors.
Anqing Huang, Yuli Huang
doaj   +1 more source

The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. [PDF]

PLoS Genetics, 2015
Wnt and Netrin signaling regulate diverse essential functions. Using a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the UNC-6/Netrin receptor UNC-5.
Naomi Levy-Strumpf, Meghan Krizus, Hong Zheng, Louise Brown, Joseph G Culotti   +4 more
doaj   +1 more source

Receptor endocytosis: Frizzled joins the ubiquitin club [PDF]

The EMBO Journal, 2010
Wnt/β‐catenin signalling is initiated by binding of secreted Wnt ligands to Frizzled and LRP5/6/Arrow co‐receptors. A new study in this issue of The EMBO Journal provides compelling evidence that the level of cell surface Frizzled is controlled by a cycle of mono‐ubiquitylation–deubiquitylation, the latter being mediated by the deubiquitylating ...
openaire   +3 more sources