Results 41 to 50 of about 19,373 (224)

Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes [PDF]

Osteoarthritis and Cartilage, 2010
Differentiated articular chondrocytes express a functional bisoform of the leptin receptor (LRb); however, leptin-LRb signaling in these cells is poorly understood. We hypothesized that leptin-LRb signaling in articular chondrocytes functions to modulate canonical Wnt signaling events by altering the expression of Frizzled (FZD) receptors.Human ...
Ohba, S., Lanigan, T.M., Roessler, B.J.
openaire   +2 more sources

The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility. [PDF]

PLoS Genetics, 2014
Wnt proteins regulate many developmental processes and are required for tissue homeostasis in adult animals. The cellular responses to Wnts are manifold and are determined by the respective Wnt ligand and its specific receptor complex in the plasma ...
Karen Linnemannstöns, Caroline Ripp, Mona Honemann-Capito, Katja Brechtel-Curth, Marie Hedderich, Andreas Wodarz   +5 more
doaj   +1 more source

Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling

Frontiers in Oncology, 2022
WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various cellular processes. While WNT ligands usually signal through their dedicated Frizzled receptors, the decision to signal in a β-catenin-dependent or -independent ...
Kinjal Shah, Kinjal Shah, Julhash U. Kazi, Julhash U. Kazi   +3 more
doaj   +1 more source

Remote activation of the Wnt/β-catenin signalling pathway using functionalised magnetic particles.

PLoS ONE, 2015
Wnt signalling pathways play crucial roles in developmental biology, stem cell fate and tissue patterning and have become an attractive therapeutic target in the fields of tissue engineering and regenerative medicine.
Michael Rotherham, Alicia J El Haj
doaj   +1 more source

Structural dynamics of receptor recognition and pH-induced dissociation of full-length Clostridioides difficile Toxin B.

PLoS Biology, 2022
Clostridioides difficile secretes Toxin B (TcdB) as one of its major virulence factors, which binds to intestinal epithelial and subepithelial receptors, including frizzled proteins and chondroitin sulfate proteoglycan 4 (CSPG4). Here, we present cryo-EM
Mengqiu Jiang, Joonyoung Shin, Rudo Simeon, Jeng-Yih Chang, Ran Meng, Yuhang Wang, Omkar Shinde, Pingwei Li, Zhilei Chen, Junjie Zhang   +9 more
doaj   +1 more source

Binding of sFRP-3 to EGF in the extra-cellular space affects proliferation, differentiation and morphogenetic events regulated by the two molecules. [PDF]

PLoS ONE, 2008
sFRP-3 is a soluble antagonist of Wnts, widely expressed in developing embryos. The Wnt gene family comprises cysteine-rich secreted ligands that regulate cell proliferation, differentiation, organogenesis and oncogenesis of different organisms ranging ...
Raffaella Scardigli, Cesare Gargioli, Daniela Tosoni, Ugo Borello, Maurilio Sampaolesi, Clara Sciorati, Stefano Cannata, Emilio Clementi, Silvia Brunelli, Giulio Cossu   +9 more
doaj   +1 more source

Control of bone formation by the serpentine receptor Frizzled-9 [PDF]

Journal of Cell Biology, 2011
Although Wnt signaling in osteoblasts is of critical importance for the regulation of bone remodeling, it is not yet known which specific Wnt receptors of the Frizzled family are functionally relevant in this process. In this paper, we show that Fzd9 is induced upon osteoblast differentiation and that Fzd9−/− mice display low bone mass caused by ...
Albers, Joachim, Schulze, Jochen, Beil, Frank Timo, Gebauer, Matthias, Baranowsky, Anke, Keller, Johannes, Marshall, Robert P., Wintges, Kristofer, Friedrich, Felix W., Priemel, Matthias, Schilling, Arndt F., Rueger, Johannes M., Cornils, Kerstin, Fehse, Boris, Streichert, Thomas, Sauter, Guido, Jakob, Franz, Insogna, Karl L., Pober, Barbara, Knobeloch, Klaus-Peter, Amling, Michael, Schinke, Thorsten, Francke, Uta   +22 more
openaire   +3 more sources

Immunohistochemical study of the canonical and non-canonical Wnt signaling pathway in colorectal carcinoma and non-neoplastic mucosa

Journal of Coloproctology, 2015
Colorectal cancer is linked to several signaling pathways such as Wnt pathway. Our objective is to detect and verify the integrity of protein members of Wnt signaling pathway in colorectal carcinoma and non-neoplastic colorectal tissue.
Rodrigo Felippe Ramos, Celina Tizuko Fujyiama Oshima, Thiago Simão Gomes, Ana Maria Amaral Antonio Mader, Caio Dal Moro Alves, Jaques Waisberg   +5 more
doaj   +1 more source

Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants

Stem Cells International, 2016
The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors.
Katharina Nothelfer, Florian Obermayr, Nadine Belz, Ellen Reinartz, Petra M. Bareiss, Hans-Jörg Bühring, Rudi Beschorner, Lothar Just   +7 more
doaj   +1 more source

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts. [PDF]

PLoS ONE, 2017
Wnt3a is a major regulator of bone metabolism however, very few of its target genes are known in bone. Wnt3a preferentially signals through transmembrane receptors Frizzled and co-receptors Lrp5/6 to activate the canonical signaling pathway.
Aimy Sebastian, Nicholas R Hum, Deepa K Murugesh, Sarah Hatsell, Aris N Economides, Gabriela G Loots   +5 more
doaj   +1 more source