Results 41 to 50 of about 18,461 (227)

The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. [PDF]

PLoS Genetics, 2015
Wnt and Netrin signaling regulate diverse essential functions. Using a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the UNC-6/Netrin receptor UNC-5.
Naomi Levy-Strumpf, Meghan Krizus, Hong Zheng, Louise Brown, Joseph G Culotti   +4 more
doaj   +1 more source

The PTK7-related transmembrane proteins off-track and off-track 2 are co-receptors for Drosophila Wnt2 required for male fertility. [PDF]

PLoS Genetics, 2014
Wnt proteins regulate many developmental processes and are required for tissue homeostasis in adult animals. The cellular responses to Wnts are manifold and are determined by the respective Wnt ligand and its specific receptor complex in the plasma ...
Karen Linnemannstöns, Caroline Ripp, Mona Honemann-Capito, Katja Brechtel-Curth, Marie Hedderich, Andreas Wodarz   +5 more
doaj   +1 more source

Remote activation of the Wnt/β-catenin signalling pathway using functionalised magnetic particles.

PLoS ONE, 2015
Wnt signalling pathways play crucial roles in developmental biology, stem cell fate and tissue patterning and have become an attractive therapeutic target in the fields of tissue engineering and regenerative medicine.
Michael Rotherham, Alicia J El Haj
doaj   +1 more source

Structural dynamics of receptor recognition and pH-induced dissociation of full-length Clostridioides difficile Toxin B.

PLoS Biology, 2022
Clostridioides difficile secretes Toxin B (TcdB) as one of its major virulence factors, which binds to intestinal epithelial and subepithelial receptors, including frizzled proteins and chondroitin sulfate proteoglycan 4 (CSPG4). Here, we present cryo-EM
Mengqiu Jiang, Joonyoung Shin, Rudo Simeon, Jeng-Yih Chang, Ran Meng, Yuhang Wang, Omkar Shinde, Pingwei Li, Zhilei Chen, Junjie Zhang   +9 more
doaj   +1 more source

Frizzled receptors in neurons: From growth cones to the synapse

Cytoskeleton, 2012
AbstractThe Wnt signaling pathway has been implicated in several different aspects of neural development and function, including dendrite morphogenesis, axonal growth and guidance, synaptogenesis and synaptic plasticity. Here, we studied several Frizzled Wnt receptors and determined their differential expression during hippocampal development.
Varela-Nallar, Lorena, Ramirez, Valerie T., Gonzalez-Billault, Christian, Inestrosa, Nibaldo C.   +3 more
openaire   +9 more sources

Iloprost requires the Frizzled-9 receptor to prevent lung cancer

iScience, 2022
Prevention of premalignant lesion progression is a promising approach to reducing lung cancer burden in high-risk populations. Substantial preclinical and clinical evidence has demonstrated efficacy of the prostacyclin analogue iloprost for lung cancer chemoprevention.
Kayla Sompel, Lori D. Dwyer-Nield, Alex J. Smith, Alamelu Elango, Don S. Backos, Bicheng Zhang, James Gross, Kristina Ternyak, Jennifer L. Matsuda, Katrina Kopf, Robert L. Keith, Meredith A. Tennis   +11 more
openaire   +3 more sources

Binding of sFRP-3 to EGF in the extra-cellular space affects proliferation, differentiation and morphogenetic events regulated by the two molecules. [PDF]

PLoS ONE, 2008
sFRP-3 is a soluble antagonist of Wnts, widely expressed in developing embryos. The Wnt gene family comprises cysteine-rich secreted ligands that regulate cell proliferation, differentiation, organogenesis and oncogenesis of different organisms ranging ...
Raffaella Scardigli, Cesare Gargioli, Daniela Tosoni, Ugo Borello, Maurilio Sampaolesi, Clara Sciorati, Stefano Cannata, Emilio Clementi, Silvia Brunelli, Giulio Cossu   +9 more
doaj   +1 more source

FZD5 (frizzled class receptor 5) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019
The Wnt signalling pathways are ways of signalling that transduce signals into cells through cell surface receptors; they are three different type of pathways and all of these are activated by binding a Wnt-protein ligand to a Frizzled family receptor.
openaire   +3 more sources

Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling

Frontiers in Oncology, 2022
WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various cellular processes. While WNT ligands usually signal through their dedicated Frizzled receptors, the decision to signal in a β-catenin-dependent or -independent ...
Kinjal Shah, Kinjal Shah, Julhash U. Kazi, Julhash U. Kazi   +3 more
doaj   +1 more source

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of receptors, including their structures and interactions with Wnt proteins, and signaling mechanisms from receptor activation to the engagement of intracellular partners ...
Bryan T. MacDonald, Xi He
openaire   +2 more sources