Results 81 to 90 of about 18,461 (227)

Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells [PDF]

BMC Cell Biology, 2007
Abstract Background Norrin is a potent Wnt pathway ligand. Aberrant activation of this signaling pathway can result in colon tumors but the role of norrin-based signaling in the genesis of colon cancer, and its relationship to activation of the pathway by traditional Wnt ligands, is not defined.
Planutis, Kestutis, Planutiene, Marina, Moyer, Mary Pat, Nguyen, Anthony V, Perez, Cherlyn A, Holcombe, Randall F   +5 more
openaire   +5 more sources

Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor [PDF]

Current Biology, 2010
Wnt/Wg signaling pathways are of key importance during development and disease. Canonical and noncanonical Wnt/Frizzled (Fz) pathways share a limited number of signaling components that are part of the membrane proximal signaling complex. In Drosophila, Fz and Dishevelled (Dsh) are the only two components known to be involved in both Wnt/beta-catenin ...
Michael Boutros, Kerstin Spirohn, Bisei Ohkawara, Tina Buechling, Varun Chaudhary, Christof Niehrs, Kerstin Bartscherer   +6 more
openaire   +3 more sources

Documenting den characteristics of bears and wolves in the Greater Yellowstone Ecosystem using LIDAR technology

Wildlife Society Bulletin, EarlyView.
Previous studies have documented den site characteristics through physical measurements recorded by researchers in the field. Using the light detection and ranging (LiDAR) sensor onboard an Apple iPad Pro, we scanned the interior of black and grizzly bear dens (n = 9) located in the Greater Yellowstone Ecosystem (GYE) to generate point clouds of den ...
Tyler J. Brasington, Jessica M. Hadley, Justin K. Schwabedissen, John A. Stephenson   +3 more
wiley   +1 more source

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

Aging Cell, EarlyView.
Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targets collagen remodeling and stem cell function‐related genes.
Toby L. Chambers, Jaden Wells, Pieter Jan Koopmans, Francielly Morena, Zain B. Malik, Nicholas P. Greene, Antonio Filareto, Michael Franti, Patrizia Sini, Harald Weinstabl, Robert T. Brooke, Milda Milčiūtė, Juozas Gordevičius, Steve Horvath, Yuan Wen, Cory M. Dungan, Kevin A. Murach   +16 more
wiley   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Making sense of Wnt signaling – linking hair cell regeneration to development

Frontiers in Cellular Neuroscience, 2015
Wnt signaling is a highly conserved pathway crucial for development and homeostasis of multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to regulate diverse processes such as axis patterning, cell division, and cell fate specification.
Lina eJansson, Grace eKim, Alan G Cheng
doaj   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng, Jasper F. Ooms, Erik H. J. Danen, Laura H. Heitman   +3 more
wiley   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

Phenotypic patterns of metabolic dysfunction‐associated steatotic liver disease in type 2 diabetes: The impact of insulin

European Journal of Clinical Investigation, EarlyView.
Abstract Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) often leads to hepatic insulin resistance (IR), yet its link to liver‐specific insulin‐mediated glucose uptake (IGLU) in type 2 diabetes (T2D) remains unclear. We aimed to explore this MASLD‐T2D relationship, addressing organ‐specific IR for personalized management and
Queralt Martín‐Saladich, Rafael Simó, Andreea Ciudin, Julia Baguña, Clara Ramirez‐Serra, Santiago Aguadé‐Bruix, Albert Roque, Maria N. Pizzi, Hug Cuéllar, Nuria Roson‐Gradaille, Miguel A. González Ballester, Juan M. Pericàs, José Raul Herance   +12 more
wiley   +1 more source

Immunohistochemical study of the canonical and non-canonical Wnt signaling pathway in colorectal carcinoma and non-neoplastic mucosa

Journal of Coloproctology, 2015
Colorectal cancer is linked to several signaling pathways such as Wnt pathway. Our objective is to detect and verify the integrity of protein members of Wnt signaling pathway in colorectal carcinoma and non-neoplastic colorectal tissue.
Rodrigo Felippe Ramos, Celina Tizuko Fujyiama Oshima, Thiago Simão Gomes, Ana Maria Amaral Antonio Mader, Caio Dal Moro Alves, Jaques Waisberg   +5 more
doaj