Results 81 to 90 of about 19,373 (224)

Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition

PROTEOMICS, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs) to the EMT process, a proteome analysis of MBRs released from Madin–Darby canine kidney (MDCK) cells and
Adnan Shafiq, Alin Rai, Rong Xu, Maoshan Chen, Wittaya Suwakulsiri, David W. Greening, Richard J. Simpson   +6 more
wiley   +1 more source

Mapping River Bed Topography in Whitewater Rapids Using Bathymetric LiDAR

River Research and Applications, EarlyView.
ABSTRACT Bathymetric LiDAR captures river topography efficiently for clear and shallow water, but for mountain rivers, whitewater rapids still pose challenges. This study proposes a novel method to enable the extraction of bottom returns specifically in turbulent whitewater sections.
Jan Rhomberg‐Kauert, Theresa Himmelsbach, Florian Pöppl, Lucas Dammert, Martin Pfennigbauer, Gottfried Mandlburger   +5 more
wiley   +1 more source

Frizzled Proteins are bona fide G Protein-Coupled Receptors

Nature Precedings, 2009
AbstractReceptors of the Frizzled family initiate Wnt ligand-dependent signaling controllingmultiple steps in organism development and highly conserved in evolution.Misactivation of the Wnt/Frizzled signaling is cancerogenic. Frizzled receptorslaunch several signaling cascades: the canonical pathway regulating beta-catenin-dependent transcription; the ...
Vladimir L. Katanaev, Silke Buestorf
openaire   +2 more sources

Plasma Proteomics Analysis Identifying IGFBP2 as a Potential Diagnostic Biomarker for Laryngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Currently, there are no blood biomarkers available for the early diagnosis of laryngeal squamous cell carcinoma (LSCC). The objective of this study was to search for potential plasma biomarkers for the diagnosis of LSCC. Methods Plasma samples were taken from patients with LSCC and healthy controls for proteomic analysis.
Shuang Teng, Ling‐Mei Qu, Jun‐Jie Liu, Yu‐Shan Li, Zi‐Qi Chen, Shuo Liu, Zhao‐Nan Xu, Meng Jin, Qiu‐Ying Li, Qin Wu, Hong‐Tian Yi, Xian‐Ji Shen, Bing‐Rui Yan, Ya‐Nan Sun   +13 more
wiley   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Making sense of Wnt signaling – linking hair cell regeneration to development

Frontiers in Cellular Neuroscience, 2015
Wnt signaling is a highly conserved pathway crucial for development and homeostasis of multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to regulate diverse processes such as axis patterning, cell division, and cell fate specification.
Lina eJansson, Grace eKim, Alan G Cheng
doaj   +1 more source

Microtubule Inhibitors Induce Cross‐Resistance to Osimertinib Through CaMKII Activation in EGFR‐Mutated NSCLC

Cancer Science, EarlyView.
Eighteen‐week treatment with microtubule inhibitors induces resistance to osimertinib in EGFR‐mutated NSCLC cells. Vinorelbine‐ and paclitaxel‐resistant cells showed activation of FZD7 and CaMKII and increased sensitivity to CaMKII inhibition, with additive or synergistic effects when combined with osimertinib.
Kento Kono, Ryosuke Tanino, Yukari Tsubata, Eshat Fahmida Haque, Takeshi Isobe, Tamio Okimoto   +5 more
wiley   +1 more source

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis

Mechanisms of Development, 1999
The expression of eight murine Frizzled (1,3-9) genes was studied during mouse somitogenesis, in order to correlate the Wnt-dependent activation of myogenesis with the expression of specific Frizzled putative receptors. Frizzled 1, 3, 6, 7, 8, and 9 have specific expression in the forming and differentiating somites.
Borello U, Buffa V, Sonnino C, Melchionna R, Vivarelli E, Cossu G   +5 more
openaire   +3 more sources

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source