Results 161 to 170 of about 29,955 (198)

Localization of frog virus 3 proteins using monoclonal antibodies

Virology, 1984
Thirty-seven monoclonal antibodies to seven frog virus 3 (FV3) structural proteins were isolated and used to examine the distribution of viral proteins within virions and infected cells. Three monoclonal antibodies, one to the major capsid protein, VP55, and two to VP38 had detectable neutralizing activity suggesting that these proteins are located on ...
V G, Chinchar, D W, Metzger, A, Granoff, R, Goorha   +3 more
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The inhibition of vesicular stomatitis virus protein synthesis by frog virus 3

Virology, 1979
Abstract Heat-inactivated frog virus 3 (ΔFV 3) inhibited the synthesis of vesicular stomatitis virus (VSV) proteins in BHK cells by 40 to 60%. This inhibition was apparently a direct effect on translation because (i) inhibition occurred throughout the growth cycle of VSV and (ii) it did not depend on the ability of ΔFV 3 to inhibit transcription. The
J, Tannenbaum, R, Goorha, A, Granoff
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Frog Virus 3 DNA Replication

1989
Frog virus 3 (FV3) is a large icosahedral virus belonging to the Iridoviridae family. The genome is double—stranded, linear DNA with a molecular weight of 100 x 106 (Kelly and Avery, 1974; Murti et al., 1982). Among animal viruses, FV3 was the first demonstrated to contain a circularly permuted and terminally redundant genome (Goorha and Murti, 1982 ...
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Virus-Cytoskeleton Interaction during Replication of Frog Virus 3

1990
Frog virus 3 (FV3) induces selective and sequential changes in the eukaryotic cytoskeleton. Morphologically, the virus disrupts the microtubules, reorganizes the intermediate filaments, and disrupts and reorganizes the microfilaments. Biochemically, the virus selectively inhibits tubulin synthesis, increases the phosphorylation of vimentin, and ...
K. G. Murti, R. Goorha
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Macromolecular Synthesis in Cells Infected by Frog Virus 3

1985
The best studied member of the Iridoviridae is frog virus 3 (FV3), isolated by Granoff et al. (1966) from a renal adenocarcinoma of the leopard frog, Rana pipiens. Similar isolates were made from normal frog kidney and liver (FV1, FY 2, FV5–FY24), but FV3 was chosen for further investigation because of its presence in the tumor.
D B, Willis, R, Goorha, V G, Chinchar
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Frog virus 3 DNA is heavily methylated at CpG sequences

Virology, 1980
Abstract DNA extracted from frog virus 3 (FV 3) virions was resistant to the action of restriction endonucleases that cannot cleave DNA methylated at the sequence me CpG. However, viral DNA was susceptible to digestion with at least one enzyme that recognizes an identical sequence, independent of methylation.
D B, Willis, A, Granoff
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DNA-binding Proteins in Frog Virus 3-infected Cells

Journal of General Virology, 1981
At least 12 virus-induced DNA-binding proteins with mol. wt. ranging from 14 X 10(3) have been isolated from frog virus (FV 3)-infected fathead minnow cells by DNA affinity chromatography. Two enzymic activities, DNA-dependent DNA polymerase and endodeoxyribonuclease, were present in the DNA-binding proteins; these enzymic activities were similar to ...
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Thymidine kinase induction in frog virus 3 infected mouse cells

Virology, 1974
Abstract Infection of LTK− cells with FV3 at 28 °C was followed by the induction of thymidine kinase. The conditions for an optimal activity of the enzyme in vitro were determined. The enzyme induction occurred only under permissive conditions for viral multiplication; no thymidine kinase was detected after infection at 37 °C or with heatinactivated ...
A M, Aubertin, M O, Lonchampt
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A preliminary translational map of the frog virus 3 genome

Virus Genes, 1994
A preliminary map of the frog virus 3 (FV 3) genome was constructed by hybridization-selection of mRNAs to cloned DNA fragments and translation in reticulocyte lysates. FV 3 mRNAs were hybridized to KpnI, HindIII, and SalI restriction fragments representing the entire FV 3 genome.
P D, Foglesong, D B, Willis
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Instability of Frog Virus 3 mRNA in Productively Infected Cells

Virology, 1994
Cloned DNA restriction fragments encoding representative frog virus 3 messages were used as probes to assess the stability of viral transcripts in infected fathead minnow cells. Analysis of Northern blot hybridization profiles confirmed earlier findings and revealed that in infected cells the steady-state level of representative frog virus 3 (FV3 ...
V G, Chinchar, J, Han, J, Mao, I, Brooks, K, Srivastava   +4 more
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