Results 81 to 90 of about 9,722 (181)

Inhibition of Foot-and-Mouth Disease Virus Replicase by Frog Virus 3 Particles

Journal of General Virology, 1974
Summary A cell-free system synthesizing FMDV RNA has been shown to be inhibited efficiently by purified FV3 particles. Neither vaccinia nor herpes virus particles produced this effect. The results obtained provide direct evidence that a structural component (or components) or FV3 is responsible for the inhibition.
R, Barzilai, L H, Lazarus
openaire   +2 more sources

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Identification and Optimization of a Truncated Hs‐1‐Derived Antimicrobial Peptide for Enhanced Broad‐Spectrum Antiviral Activity

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Can a shorter peptide be a better antiviral? Structure‐guided optimization of the amphibian peptide Hs‐1 reveals a minimal α‐helical core that, after terminal modification, displays enhanced stability and submicromolar broad‐spectrum activity against enveloped viruses while maintaining a favorable safety profile. Antimicrobial peptides (AMPs) represent
Carla Zannella, Annalisa Chianese, Rosa Giugliano, Roberta Della Marca, Alessandra Monti, Martina Dragone, Gaetano Malgieri, Nunzianna Doti, Carla Isernia, Anna De Filippis, Massimiliano Galdiero   +10 more
wiley   +1 more source

Frog Virus 3 Morphogenesis: Effect of Temperature and Metabolic Inhibitors

Journal of General Virology, 1977
The different stages of frog virus 3 (FV 3) morphogenesis have been investigated in chick embryo fibroblasts infected at an optimal temperature for virus growth (29 degrees C). The metabolic requirements for morphogenesis were determined by adding inhibitors of macromolecular synthesis at different periods in the virus growth cycle. The effect of a non-
F, Tripier, J, Braunwald, L, Markovic, A, Kirn   +3 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, Volume 600, Issue 13, Page 1859-1871, July 2026.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

NaP‐TRAP: A Versatile and Accessible Workflow to Dissect Principles of Translational Regulation and mRNA Stability

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract The translation of messenger RNA (mRNA) into protein is tightly regulated by both cellular trans‐factors and cis‐regulatory elements encoded within transcripts. Although transcript fate can be measured by transcript abundance or translation efficiency, separating the contribution of individual cis‐element within a single transcript is an ...
Amit Gupta, Anna Z. Struba, Srihari Madhavan, Ethan Strayer, Jean‐Denis Beaudoin   +4 more
wiley   +1 more source

Complete blood counts for free-living Terrapene carolina carolina encountered during and after a frog virus 3-like ranavirus mortality event in Kennekuk Cove County Park, Vermilion County, Illinois in 2013. [PDF]

, 2018
Complete blood counts for free-living Terrapene carolina carolina encountered during and after a frog virus 3-like ranavirus mortality event in Kennekuk Cove County Park, Vermilion County, Illinois in 2013.
Michael J. Kinsel (5067086), Kayla Boers (5067092), Elizabeth Driskell (5067101), Matthew C. Allender (813919), Marta Rzadkowska (5067098), Chris Phillips (743668), Grace Archer (5067089), Caroline Chu (322930), Laura Adamovicz (5067095)   +8 more
core   +1 more source

Exploring the Effectiveness of Acyclovir against Ranaviral Thymidine Kinases: Molecular Docking and Experimental Validation in a Fish Cell Line

Life
The effectiveness of acyclovir, a selective anti-herpesvirus agent, was tested both in silico and in vitro against two ranaviruses, namely the European catfish virus (ECV) and Frog virus 3 (FV3).
Richárd Rácz, Ákos Gellért, Tibor Papp, Andor Doszpoly   +3 more
doaj   +1 more source

Temperature affects the host hematological and cytokine response following experimental ranavirus infection in red-eared sliders (Trachemys scripta elegans).

PLoS ONE, 2020
Pathogen-host interactions are important components of epidemiological research, but are scarcely investigated in chelonians. Red-eared sliders (Trachemys scripta elegans), are recognized as a model for frog virus-3 infection (FV3), a ranavirus in the ...
Jeremy M Rayl, Matthew C Allender
doaj   +1 more source

Pathogen Risk Analysis for Wild Amphibian Populations Following the First Report of a Ranavirus Outbreak in Farmed American Bullfrogs (Lithobates catesbeianus) from Northern Mexico

Viruses, 2019
Ranaviruses are the second deadliest pathogens for amphibian populations throughout the world. Despite their wide distribution in America, these viruses have never been reported in Mexico, the country with the fifth highest amphibian diversity in the ...
Bernardo Saucedo, José M. Serrano, Mónica Jacinto-Maldonado, Rob S. E. W. Leuven, Abraham A. Rocha García, Adriana Méndez Bernal, Andrea Gröne, Steven J. van Beurden, César M. Escobedo-Bonilla   +8 more
doaj   +1 more source