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British Journal of Psychiatry, 2002 BackgroundFrontotemporal dementia accounts for up to 20% of cases of dementia in the presenium, yet remains poorly recognised. Diagnostic criteria have been devised to aid clinical diagnosis.AimsTo provide an overview of clinical and pathological characteristics of frontotemporal dementia and its nosological status.MethodsThe review summarises ...
Snowden, Julie S. +2 more
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BMJ, 2013 Frontotemporal dementia (FTD) encompasses several clinical syndromes that involve a progressive change in behavior and/or language; it is more common than Alzheimer's disease in early-onset dementia under the age of 60 years. In the behavioral variant of FTD (bvFTD) patients have social and emotional changes with prominent disinhibition, apathy, lack ...
Warren, JD, Rohrer, JD, Rossor, MN
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Neurologic Clinics, 2017 Frontotemporal dementia (FTD) is a heterogeneous disorder with distinct clinical phenotypes associated with multiple neuropathologic entities. Presently, the term FTD encompasses clinical disorders that include changes in behavior, language, executive control, and often motor symptoms.
Olney, Nicholas T +2 more
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The Lancet, 2015 Frontotemporal dementia is an umbrella clinical term that encompasses a group of neurodegenerative diseases characterised by progressive deficits in behaviour, executive function, or language. Frontotemporal dementia is a common type of dementia, particularly in patients younger than 65 years. The disease can mimic many psychiatric disorders because of
Bang, Jee +2 more
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Neurologic Clinics, 2016 Frontotemporal dementia (FTD) is a not-uncommon explanation for progressive cognitive deficit in patients who often have a genetic susceptibility for such a neurodegenerative process. However, FTD does not seem to identify one particular pathogenetic mechanism but rather a spectrum of pathologies with particular predilection for the frontal and ...
Roger E, Kelley, Ramy, El-Khoury
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Frontotemporal Dementias: A Review [PDF]
Annals of General Psychiatry, 2007 Abstract Dementia is a clinical state characterized by loss of function in multiple cognitive domains. It is a costly disease in terms of both personal suffering and economic loss. Frontotemporal dementia (FTD) is the term now preferred over Picks disease to describe the spectrum of non-Alzheimers dementias characterized by focal atrophy of ...
Rehan Aziz +3 more
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Frontotemporal Dementias [PDF]
CONTINUUM: Lifelong Learning in Neurology, 2016 This article reviews the common behavioral and cognitive features of frontotemporal dementia (FTD) and related disorders as well as the distinguishing clinical, genetic, and pathologic features of the most common subtypes.Advances in clinical phenotyping, genetics, and biomarkers have enabled improved predictions of the specific underlying molecular ...
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Treatment of Frontotemporal Dementia [PDF]
Current Treatment Options in Neurology, 2014 Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative diseases with heterogeneous clinical presentations and two predominant types of underlying neuropathology. FTD typically comprises three distinct clinical syndromes: behavioral variant frontotemporal dementia (bvFTD), semantic variant primary progressive aphasia (svPPA), and ...
Tsai, Richard M, Boxer, Adam L
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Genetics of Frontotemporal Dementia [PDF]
Current Neurology and Neuroscience Reports, 2016 Frontotemporal dementia (FTD) is the second most common cause of dementia following Alzheimer's disease (AD). Between 20 and 50% of cases are familial. Mutations in MAPT, GRN and C9orf72 are found in 60% of familial FTD cases. C9orf72 mutations are the most common and account for 25%. Rarer mutations (
Emer Fallon +3 more
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Inheritance of Frontotemporal Dementia [PDF]
Archives of Neurology, 1999 Previous studies of families with fronto-temporal dementia (FTD) support an autosomal dominant inheritance pattern, but most studies have described genetic transmission in individual families specifically selected for the presence of multiple affected individuals.To investigate the familial presentation and inheritance of FTD and related disorders ...
Tiffany W. Chow +3 more
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