Results 151 to 160 of about 92,917 (264)
Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
NAD+‒circadian rhythm coupling in dementia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang +7 more
wiley +1 more source
Bibliometric analysis of Alzheimer's and dementia research in Latin America
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Dementia is increasing rapidly in Latin America and the Caribbean (LAC), but research output remains limited. Tracking publication trends, themes, and collaborations is key to guiding regional research and policy. METHODS Bibliometric analysis was conducted on dementia‐related publications from 21 LAC countries (1990 to 2024 ...
Mauricio Vazquez‐Guajardo +7 more
wiley +1 more source
Peripheral immune profiling in frontotemporal dementia. [PDF]
Brain CommunGamez N +7 more
europepmc +1 more source
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Accurate clinical diagnosis of neurodegenerative diseases remains challenging, particularly when individuals have mixed pathologies. We implemented the generalizable protein‐based neurodegenerative disease artificial intelligence (GPND‐AI) classifier using the NUcleic acid‐Linked Immuno‐Sandwich Assay (NULISA) central nervous ...
Ying Xu +25 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Cognitive reserve (CR) refers to the brain's ability to maintain cognitive performance despite neurodegeneration. Studying CR in semantic variant primary progressive aphasia (svPPA) may clarify variability in disease progression and identify protective factors.
Lauren A. Grebe +17 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Functional decline in activities of daily living (ADL)—advanced (AADL), instrumental (IADL), and basic (BADL)—is a hallmark of Alzheimer's disease (AD). However, integrated clinical–neuroanatomical evidence on progression across the AD continuum remains limited, particularly in Latin American populations.
Fernando Henríquez +11 more
wiley +1 more source
Annals of Neurology, Volume 99, Issue 5, Page 1315-1326, May 2026.Objective Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f‐FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f‐FTLD.
Shubir Dutt +82 more
wiley +1 more source
Aberrant Brain Entropy in Alzheimer's Disease: Evidence From a Resting‐State fMRI Study
Brain and Behavior, Volume 16, Issue 5, May 2026.ABSTRACT Background The neurodegenerative disorder, Alzheimer's disease (AD), is typified by insidious onset and increasing prevalence with advancing age. It primarily causes comprehensive functional decline in memory, language, and executive control.
Xuke Zhang +10 more
wiley +1 more source
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory [PDF]
, 2018 et al,, Fagan, Anne M, Jerome, Gina
core +1 more source