Results 151 to 160 of about 315,827 (302)

Neuropathology of frontotemporal lobar degeneration: A review

Dementia & Neuropsychologia
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD)
Valéria Santoro Bahia, Leonel Tadao Takada, Vincent Deramecourt   +2 more
doaj   +1 more source

One of the Many Things That I've Learned on This Journey…: A Co‐operative, Narrative Inquiry With Two Care Partners of Spouses With Young Onset Dementia

Health Expectations, Volume 29, Issue 5, October 2026.
ABSTRACT Introduction Young‐onset dementia (YOD) is a term used when people demonstrate symptoms or are diagnosed with dementia before 65 years of age. YOD can be challenging to diagnose because health practitioners often do not initially consider dementia as the cause of someone's change in health or function in their 40 s, 50 s or even early 60 s ...
Elissa Burton, Vicki Barry, Bronte Parkin, Deborah Hersh   +3 more
wiley   +1 more source

Involving People With Dementia in Research: Contributions, Barriers and Evaluation From a Meta‐Synthesis and Qualitative Interview Study

Health Expectations, Volume 29, Issue 5, October 2026.
ABSTRACT Background Patient and Public Involvement and Engagement (PPIE) can enhance the relevance, acceptability and quality of research; however, its meaningful implementation in dementia research remains insufficiently understood. Aim (1) To identify methodological procedures for involving people with dementia (PwD) across the research lifecycle ...
Jörg Meisser, Susanne de Wolf‐Linder, Christina Ramsenthaler   +2 more
wiley   +1 more source

Clean, Pleasant, Governed: A Critical Discourse Analysis of Bathing Without a Battle

Nursing Inquiry, Volume 33, Issue 4, October 2026.
ABSTRACT Bathing Without a Battle is a widely circulated video training resource in residential dementia care, but the assumptions it advances about bathing, refusal, and appropriate nursing practice have received limited critical attention. This paper analyzes how the text constructs resistance to assisted bathing and how it frames legitimate nursing ...
Patricia Morris, Rose McCloskey, Janet Durkee‐Lloyd, Karla O'Regan   +3 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1780-1790, September 2026.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Non-verbal sound processing in the primary progressive aphasias [PDF]

, 2010
Little is known about the processing of non-verbal sounds in the primary progressive aphasias. Here, we investigated the processing of complex non-verbal sounds in detail, in a consecutive series of 20 patients with primary progressive aphasia [12 with ...
Goll, J. C., Loo, J. H. Y., Warren, J. D., Frost, C., Rohrer, J. D., Crutch, S. J., Bamiou, D.-E.   +6 more
core  

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, Volume 13, Issue 51, 14 September 2026.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, Volume 13, Issue 51, 14 September 2026.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Co‐pathologies – including Lewy body, vascular, and TDP‐43 lesions – are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co‐pathologies remains unclear.
Madison M. Reeves, Anna Calliari, Tiffany W. Todd, Candela Maroto Cidfuentes, Karen Jansen‐West, Mei Yue, Yuping Song, Judith Dunmore, Bailey Rawlinson, Erica Engelberg‐Cook, Michael DeTure, Gregory S. Day, Neill R. Graff‐Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Casey N. Cook, Melissa E. Murray, Dennis W. Dickson, Keith A. Josephs, Leonard Petrucelli, Mercedes Prudencio   +21 more
wiley   +1 more source

Longitudinal functional network connectivity changes across the clinical stages of C9orf72 hexanucleotide repeat expansion carriers

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross‐sectional abnormalities and longitudinal connectivity changes across clinical stages.
Liwen Zhang, Suvi Häkkinen, Youjin Jung, Maria Luisa Mandelli, Dana Leichter, Chiadi U. Onyike, Julio C. Rojas, Jolina Lombardi, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Joel Kramer, Brad F. Boeve, Adam L. Boxer, Leah K. Forsberg, Hilary W. Heuer, Kejal Kantarci, Eliana Marisa Ramos, Howard J. Rosen, Bruce L. Miller, William W. Seeley, Taru M. Flagan, Suzee E. Lee, the ARTFL/LEFFTDS/ALLFTD Consortia   +23 more
wiley   +1 more source