Results 161 to 170 of about 315,827 (302)

A world view: Considerations of sociocultural diversity in the study of subjective cognitive decline in Alzheimer's disease and related dementias

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Subjective cognitive decline (SCD) refers to cognitive concerns that may occur with or without objective impairment on standardized testing. Studies suggest that SCD may be an early clinical marker of Alzheimer's disease and related dementias, and that it can predict future objective cognitive decline and progression to dementia.
Mark A. Dubbelman, Tanisha G. Hill‐Jarrett, Silvia Chapman, Gustavo Alves Andrade dos Santos, Martina Azar, Ganesh M. Babulal, Tyler R. Bell, Mark A. Bernard, Carolina Boza‐Calvo, Anthony Q. Briggs, Omonigho Michael Bubu, Heather E. Cuevas, N. Maritza Dowling, Darlingtina K. Esiaka, Bernadette A. Fausto, Fabricio Ferreira de Oliveira, Carol E. Franz, Joyla A. Furlano, Christopher Gonzalez‐Corona, M. Aaron Guest, Veer Bala Gupta, Vivek K. Gupta, Daija Jackson, Jillian L. Joyce, Michael R. Kann, William S. Kremen, Athene Lee, Jairo E. Martinez, Arjun V. Masurkar, Maia A. McLin, Elisa de Paula França Resende, Zahra Rahemi, Brianca C. Renfro, Márlon Juliano Romero Aliberti, Shaina Shagalow, Andrea Slachevsky, Juliana N. De Souza Talarico, Jean François Trani, Carol Van Hulle, Leah Waltrip, Stephen Ojiambo Wandera, Charles C. Windon, Mônica Sanches Yassuda, Davide V. Moretti, Elizabeth Kuhn, Elke Butterbrod, Katherine A. Gifford, Sietske A. M. Sikkes, Raphael M. Castilhos, Rachel Nosheny, Shana D. Stites, a collaboration of the Alzheimer's Association International Society to Advance Alzheimer's Research and Therapy Subjective Cognitive Decline and Diversity and Disparities Professional Interest Areas   +51 more
wiley   +1 more source

ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Metabolic dysfunction, altered adenosine signaling, and white matter abnormalities are implicated in tauopathies, but their relationship to network disconnection remains unclear. Myelinating oligodendrocytes may represent a metabolically vulnerable hub linking these processes to circuit dysfunction.
Ching‐Pang Chang, Ching‐Wen Chang, Ching‐Wen Wu, Jian Jing Siew, David Blum, Lee‐Way Jin, You‐Yin Chen, Yijuang Chern   +7 more
wiley   +1 more source

Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION While both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) involve vascular dysfunction, the ocular microvascular differences between them remain largely underinvestigated. METHODS This cross‐sectional study included 650 participants (149 AD, 276 CSVD, and 225 cognitively unimpaired individuals).
Ziyi Zhang, Le Cao, Peng Liu, Shiyun Yang, Yuying Yan, William Robert Kwapong, Ying He, Mingyuan Yang, Hang Wang, Youjie Wang, Zijuan Feng, Jingyu Zhou, Ming Liu, Peng Lei, Bo Wu, Shuting Zhang   +15 more
wiley   +1 more source

Shared genetic architecture between DTI‐ALPS traits and neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear. METHODS By integrating genome‐wide association datasets for three DTI‐ALPS traits and seven NDDs, we quantified polygenic overlap using MiXeR ...
Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, Beisha Tang, Xinhua Wei, Lu He, Feng Liu   +10 more
wiley   +1 more source

Frontotemporal dementia in Hispanic populations: Regional and national comparisons. [PDF]

Alzheimers Dement (Amst)
Lavigne SB, Hromas G, LaRoche A, Parker AS, Abdullah MS, Fernandez RA, Wang CP, de Erausquin G, Salardini A, Tanner J, Kautz TF, Castro J, Mendoza C, Seshadri S, Sullivan AC.   +14 more
europepmc   +1 more source

SynthPET: A 3D generative AI approach for FDG‐PET image synthesis from T1‐weighted MRI and ASL CBF in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Fluorodeoxyglucose (FDG) positron emission tomography (PET) is widely used for detecting metabolic changes associated with neurodegeneration in Alzheimer's disease (AD) and other dementias but is costly and involves ionizing radiation. Here we developed SynthPET, a multimodal deep learning framework that synthesizes FDG PET images
Xavier Beltran‐Urbano, Katie R. Jobson, Ilya M. Nasrallah, Ajay Kumar, Manuel Taso, Sandhitsu R. Das, Christopher A. Brown, Sipei Li, Long Xie, Corey T. McMillan, Paul A. Yushkevich, Dave A. Wolk, Greg Zaharchuk, Sudipto Dolui, John A. Detre, for the Alzheimer's Disease Neuroimaging Initiative   +15 more
wiley   +1 more source

Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia. [PDF]

JAMA Neurol
Olzinski M, Downer J, Cobigo Y, Rajbanshi B, Li J, Loureiro J, Worringer KA, Heuer H, Ljubenkov P, Vandevrede L, Staffaroni A, Lario-Lago A, Leichter D, Wolf A, Wise A, Sanderson-Cimino M, Barragan E, Spina S, Grinberg LT, Seeley WW, Casaletto KB, Kramer J, Ramos EM, Geschwind D, Cook C, Petrucelli L, Forsberg LK, Gendron T, Boeve BF, Perneel J, Rademakers R, Rosen HJ, Saloner R, Boxer AL, Rojas JC, ALLFTD consortium.   +35 more
europepmc   +1 more source

Hippocampal snRNA‐seq in Collaborative Cross reveals molecular signatures of cognitive resilience independent of chronological aging

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Genetic factors contribute to variability in age‐related cognitive decline, yet the molecular mechanisms underlying cognitive resilience remain poorly understood. METHODS We performed single‐nucleus RNA sequencing on hippocampal tissue from 107 genetically diverse Collaborative Cross mice across three ages (6, 12, and 18 months ...
Yu Chen, Andrew R. Ouellette, Yiding Cao, Jigang Zhang, Catherine C. Kaczorowski   +4 more
wiley   +1 more source

A rostral prefrontal mediolateral gradient predicts creativity in frontotemporal dementia. [PDF]

Brain
Altmayer V, Ovando-Tellez M, Bieth T, Batrancourt B, Rametti-Lacroux A, Moreno-Rodriguez S, Bouzigues A, Ledu V, Garcin B, Lopez-Persem A, Margulies D, Levy R, Volle E, ECOCAPTURE study group .   +13 more
europepmc   +1 more source

MARBLE: An in vivo MRI marker of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC)

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA binding protein 43 kDa encephalopathy neuropathologic change (LATE‐NC) is common in older adults, yet definitive diagnosis is only possible at autopsy. METHODS This work developed a fully automated in vivo marker of LATE‐NC named MARBLE (MARker of Brain LatE) by applying ...
Mahir Tazwar, Arnold M. Evia, Abdur R. Ridwan, Sue E. Leurgans, Maude Wagner, Alzheimer's Disease Neuroimaging Initiative, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis   +8 more
wiley   +1 more source