Results 1 to 10 of about 17,167 (117)

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

Stem Cell Reports, 2018
Summary: Tauopathies such as frontotemporal dementia (FTD) remain incurable to date, partially due to the lack of translational in vitro disease models.
Joke Reumers, Ilse Van Den Wyngaert, An De Bondt   +2 more
exaly   +3 more sources

Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation [PDF]

Journal of Lipid Research
Mutations in microtubule-associated protein Tau (MAPT), the gene that codes for the protein Tau, cause frontotemporal lobar degeneration (FTLD) with phenotypes ranging from behavioral changes to cognitive impairment and parkinsonism.
Almudena Maroto-Juanes, Thomas Vogels, Sascha Koppes-den Hertog, Maarten Loos, Dieter Lütjohann, Martin Giera, Rik van der Kant   +6 more
doaj   +2 more sources

Empirical analysis of IPv6 transition technologies using the IPv6 Network Evaluation Testbed [PDF]

EAI Endorsed Transactions on Industrial Networks and Intelligent Systems, 2015
IPv6 has yet to become more than a worthy successor of IPv4, which remains, for now, the dominant Internet Protocol. This is due to the complicated transition period through which the Internet will have to go, until IPv6 will completely replace IPv4. One
Marius Georgescu, Hiroaki Hazeyama, Youki Kadobayashi, Suguru Yamaguchi   +3 more
doaj   +1 more source

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse

Frontiers in Aging Neuroscience, 2023
Tau is a microtubule-associated protein with a diverse functional repertoire linked to neurodegenerative disease. Recently, a human tau knock-in (MAPT KI) mouse was developed that may overcome many limitations associated with current animal models used ...
Matthew J. Benskey, Spencer Panoushek, Takashi Saito, Takashi Saito, Takaomi C. Saido, Tessa Grabinski, Nicholas M. Kanaan, Nicholas M. Kanaan   +7 more
doaj   +1 more source

Inhibition of MAPT enhances the effect of bexarotene and attenuates the damage after traumatic brain injury using in vivo and in vitro experiments

Folia Neuropathologica, 2020
Traumatic brain injury (TBI) is the leading cause of death and disability around the world in all age groups. The primary injury of TBI is exacerbated by secondary injury, leading to an increased inflammatory response, cell death and even impairment of ...
Haihai Dong, Haitao Wang, Liang Wang
doaj   +1 more source

Mitochondrial Defects in Fibroblasts of Pathogenic MAPT Patients

Frontiers in Cell and Developmental Biology, 2021
Mutations in MAPT gene cause multiple neurological disorders, including frontal temporal lobar degeneration and parkinsonism. Increasing evidence indicates impaired mitochondrial homeostasis and mitophagy in patients and disease models of pathogenic MAPT.
Vinita Bharat, Chung-Han Hsieh, Xinnan Wang   +2 more
doaj   +1 more source

DNA methylation in Parkinson disease

Анналы клинической и экспериментальной неврологии, 2020
Parkinson disease (PD) is one of the most widespread neurodegenerative diseases in the elderly. It causes motor impairment and the development of non-motor symptoms, which reduce the quality of life and gradually lead to patient disability.
Elena V. Yakovenko, Ekaterina Yu. Fedotova, Sergey N. Illarioshkin   +2 more
doaj   +1 more source

Blood MAPT expression and methylation status in Alzheimer's disease

PCN Reports, 2022
Aim This study aimed to investigate the expression levels and methylation status of microtubule‐associated protein tau (MAPT) in the blood of Alzheimer's disease (AD) patients and age‐ and sex‐matched healthy controls. Methods Fifty AD outpatients and 50
Hiroaki Mori, Yuta Yoshino, Mariko Ueno, Yu Funahashi, Hiroshi Kumon, Yuki Ozaki, Kiyohiro Yamazaki, Shinichiro Ochi, Jun‐ichi Iga, Shu‐ichi Ueno   +9 more
doaj   +1 more source

Neuroprotective Effect of Astragaloside IV on Cerebral Ischemia/Reperfusion Injury Rats Through Sirt1/Mapt Pathway

Frontiers in Pharmacology, 2021
Background: Ischemic stroke is a common disease with poor prognosis, which has become one of the leading causes of morbidity and mortality worldwide. Astragaloside IV (AS-IV) is the main bioactive ingredient of Astragali Radix (which has been used for ...
Yi-Hua Shi, Xi-Le Zhang, Peng-Jie Ying, Zi-Qian Wu, Le-Le Lin, Wei Chen, Guo-Qing Zheng, Wen-Zong Zhu   +7 more
doaj   +1 more source

Knockdown of LncRNA MAPT-AS1 inhibites proliferation and migration and sensitizes cancer cells to paclitaxel by regulating MAPT expression in ER-negative breast cancers

Cell & Bioscience, 2018
Background MAPT-AS1, a long non-coding RNA, has not been reported in any previous research about its function in cancers. In this study, we investigated the role of MAPT-AS1 in the progression and paclitaxel resistance in breast cancer, and the ...
Yiyuan Pan, Yiqi Pan, Yue Cheng, Fan Yang, Zhihan Yao, Ouchen Wang   +5 more
doaj   +1 more source