Results 31 to 40 of about 20,159 (186)

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels [PDF]

, 2014
Introduction: MAPT encodes for tau, the predominant component of neurofibrillary tangles that are neuropathological hallmarks of Alzheimer’s disease (AD). Genetic association of MAPT variants with late-onset AD (LOAD) risk has been inconsistent, although
John K Kauwe, Parisi, Joseph, Nguyen, Thuy, Haines, Jonathan, Kimberly Malphrus, Sarah Lincoln, Pankratz, V, Schellenberg, Gerard, Graff-Radford, Neill, Gerard D Schellenberg, Crook, Julia E, Carrasquillo, Minerva M, Crane, Paul, Jin Jen, Ma, Li, Chai, High Seng, Margaret A Pericak-Vance, Dennis W Dickson, Haines, Jonathan L, Pericak-Vance, Margaret A, Petersen, Ronald C, High Chai, Quicksall, Zachary, Chai, High, Farrer, Lindsay, Alzheimer's Dis Genetics Consortiu, Paul K Crane, Neill R Graff-Radford, Kolbert, Christopher P, Farrer, Lindsay A, Richard Mayeux, Younkin, Curtis, Mayeux, Richard Paul, V Pankratz, Malphrus, Kimberly, Pankratz, V Shane, Shubhabrata Mukherjee, Siddharth Krishnan, null null, Zou, Fanggeng, Crane, Paul K, Mukherjee, Shubhabrata, Schellenberg, Gerard D, Curtis Younkin, Jonathan L Haines, Michaela Kachadoorian, Fanggeng Zou, Kauwe, John, Christopher P Kolbert, Mariet Allen, Parisi, Joseph E, Kachadoorian, Michaela, Younkin, Steven, Allen, Mariet, Crook, Julia, Li Ma, Dickson, Dennis, Minerva M Carrasquillo, Younkin, Steven G, Julia E Crook, Thuy Nguyen, Graff-Radford, Neill R, Pericak-Vance, Margaret, Kolbert, Christopher, Lindsay A Farrer, Steven G Younkin, Kauwe, John K, Bisceglio, Gina, Petersen, Ronald, Gina Bisceglio, Joseph E Parisi, Ertekin-Taner, Nilüfer, Ronald C Petersen, Mayeux, Richard, Jen, Jin, Zachary Quicksall, Lincoln, Sarah, Nilüfer Ertekin-Taner, Carrasquillo, Minerva, Dickson, Dennis W, Krishnan, Siddharth   +80 more
core   +2 more sources

Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer

BMC Cancer, 2019
Background Microtubule-associated protein Tau (MAPT) overexpression has been linked to poor prognosis and decreased response to taxane-based therapies in several cancer types, but its relevance in prostate cancer is unknown.
Cornelia Schroeder, Jan Grell, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Ronald Simon, Doris Höflmayer, Sarah Minner, Eike Burandt, Till S. Clauditz, Franziska Büscheck, Frank Jacobsen, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Guido Sauter, Stefan Steurer   +16 more
doaj   +1 more source

Mouse and Human Tau Expression in Different Brain Areas

Journal of Alzheimer's Disease Reports, 2022
Background: An increase in tau protein is believed to be necessary for tau aggregation. However, whether this is due to increased expression of the endogenous tau promoter or protein accumulation due to proteostasis failure remains uncertain.
Laura Vallés-Saiz, Daniel Ruiz-Gabarre, Vega García-Escudero, George Perry, Jesús Avila, Félix Hernández   +5 more
doaj   +1 more source

Mapt isoforms in guinea pig brain. [PDF]

, 2013
A) Schematic diagram of the alternative splicing pattern of human Mapt. Six Mapt isoforms (0N3R, 1N3R, 2N3R, 0N4R, 1N4R, 2N4R) are generated from alternative splicing of exon2, 3 and 10 of the solo Mapt gene.
Daniel Ong (425319), Mathew J. Sharman (425316), Morgan Newman (425323), Linda Wijaya (425320), Michael Lardelli (349174), Ralph N. Martins (389271), Kevin Taddei (425322), Simon M. Laws (425321), Seyyed H. Moussavi Nik (425317), Mengqi M. Chen (425318), Giuseppe Verdile (425324)   +10 more
core   +1 more source

The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells

Journal of Diabetes Research, 2016
Structural and biochemical alterations of the microtubule-associated protein tau (MAPT) are associated with degenerative disorders referred to as tauopathies. We have previously shown that MAPT is present in human islets of Langerhans, human insulinomas,
Magdalena Maj, Gregor Hoermann, Sazan Rasul, Wolfgang Base, Ludwig Wagner, Johannes Attems   +5 more
doaj   +1 more source

Retromer regulates the lysosomal clearance of MAPT/tau [PDF]

, 2021
Data source: Supplementary material, https://doi.org/10.1080/15548627.2020.1821545The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading ...
Hein, L.K., Singh, S., Denton, D., Bardy, C., Milky, B., Carosi, J.M., van den Hurk, M., Kumar, S., Adams, R., Sargeant, T.J.   +9 more
core   +1 more source

Microtubule Associated Protein-Tau (MAPT) Is Influenced by ER: ICI182,780, a Selective ER Inhibitor, Down-Regulates MAPT Expression and Reverses Resistance to Taxanes in MAPT- and ER-Positive Breast Cancer Cells. [PDF]

, 2009
Background: Taxanes are important drugs in treatment of breast cancer. These drugs bind to tubulin and suppress spindle microtubule dynamics, which leads to cell cycle arrest in the G2/M phase followed by apoptosis.
H. Ikeda, T. Nogami, F. Hara, N. Taira, T. Shien, H. Doihara   +5 more
core   +1 more source

Haplotipos MAPT en homo sapiens [PDF]

, 2019
289 p.El objetivo principal de este proyecto de tesis ha sido tratar de desentrañar el misterio tras la peculiar distribución de los haplotipos MAPT en el mundo en general y muy en particular en el continente europeo, de donde es prácticamente exclusiva ...
Espinosa Carcabilla, Ibone
core   +3 more sources

Dissecting the Clinical Heterogeneity and Genotype-Phenotype Correlations of MAPT Mutations: A Systematic Review

Frontiers in Bioscience-Landmark
Background: Microtubule-associated protein tau (MAPT) mutations are one of the main causes of genetic Frontotemporal dementia (FTD) and are characterised by high clinical heterogeneity.
Cristina Villa, Elisa Pellencin, Aurora Romeo, Giorgio Giaccone, Giacomina Rossi, Sara Prioni, Paola Caroppo   +6 more
doaj   +1 more source

Frontotemporal dementia with the V337M MAPT mutation [PDF]

, 2017
Objective: To assess the efficacy of [ 18 F]AV1451 PET in visualizing tau pathology in vivo in a patient with frontotemporal dementia (FTD) associated with the V337M microtubule-associated protein tau (MAPT) mutation.
Schonhaut, Daniel R., Dickson, Dennis W., Murray, Melissa E, Ossenkoppele, Rik, Rabinovici, Gil D., Parisi, Joseph E, Seeley, William W., Parisi, Joseph E., Perry, David C, O'Neil, James P., Boeve, Bradley F., O'Neil, James P, Boxer, Adam L., Boeve, Bradley F, Seeley, William W, Miller, Bruce L, Spina, Salvatore, Perry, David C., Jagust, William J., Jagust, William J, Rosen, Howard J., Boxer, Adam L, Lazaris, Andreas, Rabinovici, Gil D, Miller, Bruce L., Dickson, Dennis W, Murray, Melissa E., Rosen, Howard J, Schonhaut, Daniel R   +28 more
core   +1 more source