Results 51 to 60 of about 20,159 (186)

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems [PDF]

, 2018
Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate.
Senthilvelrajan Kaniyappan (3638545), Eckhard Mandelkow (267152), Balaji, V., Kaniyappan, S., Wang, Y., Eva-Maria Mandelkow (2415553), Varun Balaji (3638548), Mandelkow, E., Yipeng Wang (9800)   +8 more
core   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Effect of MAPT-AS1 over- and knock-down expression on MAPT expression in HEK293 and SK-N-MC cells. [PDF]

, 2016
A) H1 (white columns) and H2 (black columns) haplotype MAPT promoter-driven luciferase activity. Luciferase activity is normalized to each control transfection levels.
Woojin S. Kim (228803), Kirsten G. Coupland (2852408), Carol Dobson-Stone (123798), John B. J. Kwok (123803), Marianne Hallupp (379790), Glenda M. Halliday (228807)   +5 more
core   +1 more source

The H2 MAPT haplotype is associated with familial frontotemporal dementia

Neurobiology of Disease, 2006
There is now considerable evidence that the gene encoding for tau protein (MAPT) is implicated in frontotemporal dementia (FTD). The role of MAPT haplotypes in neurodegenerative diseases has been suggested, but their contribution in familial dementia has
Roberta Ghidoni, Simona Signorini, Laura Barbiero, Elena Sina, Paola Cominelli, Aldo Villa, Luisa Benussi, Giuliano Binetti   +7 more
doaj   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

MAPT subhaplotypes in corticobasal degeneration: assessing associations with disease risk, severity of tau pathology, and clinical features

Acta Neuropathologica Communications, 2020
The microtubule-associated protein tau (MAPT) H1 haplotype is the strongest genetic risk factor for corticobasal degeneration (CBD). However, the specific H1 subhaplotype association is not well defined, and it is not clear whether any MAPT haplotypes ...
Rebecca R. Valentino, Shunsuke Koga, Ronald L. Walton, Alexandra I. Soto-Beasley, Naomi Kouri, Michael A. DeTure, Melissa E. Murray, Patrick W. Johnson, Ronald C. Petersen, Bradley F. Boeve, Ryan J. Uitti, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Michael G. Heckman   +14 more
doaj   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

微管相关蛋白Tau(MAPT)在肾透明细胞癌中的表达及意义

Zhongguo shiyan zhenduanxue, 2020
目的观察微管相关蛋白Tau(MAPT)在肾透明细胞癌(ccRCC)中的表达情况,与临床病理参数的关系以及对预后的评估价值。方法分析癌症基因组图谱(TCGA)和本院验证队列中ccRCC肿瘤组织和癌旁正常组织中MAPT的表达情况,分析与临床病理参数的关系以及生存情况。在786-O和Caki-1细胞系中敲降MAPT,观察MAPT对生物学功能的影响。结果在TCGA队列中,MAPT的表达与病理T分期(pT)、AJCC分期、Fuhrman分级和是否存在远处转移显著相关 ...
赵凌昆, 谭九峰, 崔万里, 晋学飞   +3 more
doaj  

ZMYND8 suppresses MAPT213 LncRNA transcription to promote neuronal differentiation

Cell Death and Disease, 2022
Zinc Finger transcription factors are crucial in modulating various cellular processes, including differentiation. Chromatin reader Zinc Finger MYND (Myeloid, Nervy, and DEAF-1) type containing 8 (ZMYND8), an All-Trans Retinoic Acid (ATRA)-responsive ...
Santanu Adhikary, Vipin Singh, Ramesh Choudhari, Barbara Yang, Swagata Adhikari, Enrique I. Ramos, Soumi Chaudhuri, Siddhartha Roy, Shrikanth S. Gadad, Chandrima Das   +9 more
doaj   +1 more source