Results 51 to 60 of about 22,079 (225)
Novel P397S MAPT variant associated with late onset and slow progressive frontotemporal dementia
Annals of Clinical and Translational Neurology, 2019 Mutations in the MAPT gene cause frontotemporal dementia with tau deposits. We report the novel p.P397S MAPT variant in eight subjects from five apparently nonrelated families suffering from frontotemporal dementia with autosomal dominant pattern of ...
Sergi Borrego‐Écija +11 more
doaj +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Frontiers in Molecular NeuroscienceIntroductionGenetic studies have shown that variants in the microtubule-associated protein tau (MAPT) gene, which encodes tau protein, can increase the risk for Alzheimer’s disease (AD).
Mirjana Babić Leko +16 more
doaj +1 more source
Maximum a posteriori Threshold Genomic Prediction Model for Ordinal Traits
G3: Genes, Genomes, Genetics, 2020 Due to the ever-increasing data collected in genomic breeding programs, there is a need for genomic prediction models that can deal better with big data.
Abelardo Montesinos-López +3 more
doaj +1 more source
Advanced Science, EarlyView.A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan +13 more
wiley +1 more source
Tau Isoforms: Gaining Insight into MAPT Alternative Splicing
International Journal of Molecular Sciences, 2022 Tau microtubule-associated proteins, encoded by the MAPT gene, are mainly expressed in neurons participating in axonal transport and synaptic plasticity. Six major isoforms differentially expressed during cell development and differentiation are translated by alternative splicing of MAPT transcripts.
Corsi, Andrea +3 more
openaire +3 more sources
Porcupine‐Quill‐Inspired Shape‐Morphing Biointerfaces Disassemble Biofilms
Advanced Science, EarlyView.A porcupine‐spine‐inspired dynamic offensive bio‐interface is developed for active biofilm disassembly. By coupling electrically driven nano‐dagger penetration with light‐triggered ROS generation, the surface overcomes the passive limitations of conventional mechano‐bactericidal topographies, achieving near‐complete biofilm eradication, strong ...
Feng Qian +10 more
wiley +1 more source
Haplotipos MAPT en homo sapiens [PDF]
, 2019 289 p.El objetivo principal de este proyecto de tesis ha sido tratar de desentrañar el misterio tras la peculiar distribución de los haplotipos MAPT en el mundo en general y muy en particular en el continente europeo, de donde es prácticamente exclusiva ...
Espinosa Carcabilla, Ibone
core +2 more sources
Annals of Neurology, EarlyView.Objective Epigenetic clocks are biomarkers of biological aging influenced by lifestyle and systemic factors. Accelerated epigenetic aging has been associated with neurodegeneration, but its relevance in frontotemporal dementia is unclear. We investigated biological aging in frontotemporal dementia using the GrimAge2 epigenetic clock, a DNA methylation ...
Daphne Nijland +9 more
wiley +1 more source
The H2 MAPT haplotype is associated with familial frontotemporal dementia
Neurobiology of Disease, 2006 There is now considerable evidence that the gene encoding for tau protein (MAPT) is implicated in frontotemporal dementia (FTD). The role of MAPT haplotypes in neurodegenerative diseases has been suggested, but their contribution in familial dementia has
Roberta Ghidoni +7 more
doaj +1 more source