Results 41 to 50 of about 22,079 (225)

A murine model of amyloid enhanced tauopathy: progressive changes in tau pathology and behavior [PDF]

Alzheimers Dement
Abstract BACKGROUND Our prior work demonstrated systemic P301L‐tau injections in mice with mature amyloid resulted in several‐fold enhancement of tauopathy compared to non‐transgenic (NTg) littermates. METHODS APP+PS1 mice were injected intravenously with AAV.CAP‐B10 expressing P301L tau (A/P+P301L).
Finneran D, Desjarlais T, Jackman B, Morgan D, Gordon M.   +4 more
europepmc   +2 more sources

Dissecting the Clinical Heterogeneity and Genotype-Phenotype Correlations of MAPT Mutations: A Systematic Review

Frontiers in Bioscience-Landmark
Background: Microtubule-associated protein tau (MAPT) mutations are one of the main causes of genetic Frontotemporal dementia (FTD) and are characterised by high clinical heterogeneity.
Cristina Villa, Elisa Pellencin, Aurora Romeo, Giorgio Giaccone, Giacomina Rossi, Sara Prioni, Paola Caroppo   +6 more
doaj   +1 more source

Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress

, 2021
Defects of autophagy-lysosomal protein degradation are thought to contribute to the pathogenesis of several neurodegenerative diseases, and the accumulation of aggregation prone proteins such as MAPT/Tau in Alzheimer disease (AD).
Julien Giustiniani (3123564), Béatrice Chambraud (3371201), Corentin Daguinot (9998970), Kevin Guillemeau (9998973), Christian Poüs (9282452), Melanie Genet (9378943), Geri Meduri (89811), Etienne Emile Baulieu (9998979), Omar Dounane (9998976)   +8 more
core   +1 more source

The human MAPT locus generates circular RNAs [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
The microtubule-associated protein Tau, generated by the MAPT gene is involved in dozens of neurodegenerative conditions ("tauopathies"), including Alzheimer's disease (AD) and frontotemporal lobar degeneration/frontotemporal dementia (FTLD/FTD). The pre-mRNA of MAPT is well studied and its aberrant pre-mRNA splicing is associated with frontotemporal ...
Justin R, Welden, Jacob, van Doorn, Peter T, Nelson, Stefan, Stamm   +3 more
openaire   +2 more sources

Deregulated Transcription and Proteostasis in Adult mapt Knockout Mouse

International Journal of Molecular Sciences, 2023
Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with WT mice, tau-KO mice displayed reduced anxiety-like behavior and lower fear expression induced by aversive conditioning, whereas ...
Pol Andrés-Benito, África Flores, Sara Busquet-Areny, Margarita Carmona, Karina Ausín, Paz Cartas-Cejudo, Mercedes Lachén-Montes, José Antonio Del Rio, Joaquín Fernández-Irigoyen, Enrique Santamaría, Isidro Ferrer   +10 more
openaire   +5 more sources

Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration

Translational Psychiatry, 2022
Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of protein, which can be toxic to cells and tissue.
Sidhartha Mahali, Rita Martinez, Melvin King, Anthony Verbeck, Oscar Harari, Bruno A. Benitez, Kanta Horie, Chihiro Sato, Sally Temple, Celeste M. Karch   +9 more
doaj   +1 more source

Mapt isoforms in guinea pig brain.

, 2013
A) Schematic diagram of the alternative splicing pattern of human Mapt. Six Mapt isoforms (0N3R, 1N3R, 2N3R, 0N4R, 1N4R, 2N4R) are generated from alternative splicing of exon2, 3 and 10 of the solo Mapt gene.
Daniel Ong (425319), Mathew J. Sharman (425316), Morgan Newman (425323), Linda Wijaya (425320), Michael Lardelli (349174), Ralph N. Martins (389271), Kevin Taddei (425322), Simon M. Laws (425321), Seyyed H. Moussavi Nik (425317), Mengqi M. Chen (425318), Giuseppe Verdile (425324)   +10 more
core   +1 more source

Presentation_1_Mitochondrial Defects in Fibroblasts of Pathogenic MAPT Patients.PDF

, 2021
Mutations in MAPT gene cause multiple neurological disorders, including frontal temporal lobar degeneration and parkinsonism. Increasing evidence indicates impaired mitochondrial homeostasis and mitophagy in patients and disease models of pathogenic MAPT.
Chung-Han Hsieh (787256), Vinita Bharat (11248047), Xinnan Wang (2026033)   +2 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source