Results 21 to 30 of about 20,159 (186)
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration [PDF]
, 2021 The human genome expresses thousands of natural antisense transcripts (NAT) that can regulate epigenetic state, transcription, RNA stability or translation of their overlapping genes.Hardy, JA, Mazdak Ehteramyan, Manzoni, C, Ryten, Mina, Raffaele Ferrari, Preza, E, Kay, Victoria A., Trabzuni, Daniah, Natalia Barahona-Torres, Javad, Faiza, Wray, Selina, Plagnol, Vincent, Roberto Simone, Warren Emmett, Emmett, Warren, Mina Ryten, Kia, Demis A., Wilkins, Oscar G., Svenningsson, Per, Kia, DA, Ule, J, Zuccotti, Paola, Barahona-Torres, N, Zareba-Paslawska, Justyna, Vincent Plagnol, Ehteramyan, M, Hondhamuni, Geshanthi, Ehteramyan, Mazdak, Preza, Elisavet, Elisavet Preza, Mitchell, JS, Trabzuni, D, Wilkins, OG, Harley, Jasmine, Modelska, A, Patani, Rickie, Michela A. Denti, Ferrari, Raffaele, Alan Pittman, Wray, S, Quattrone, A, Almeida, Filipa Lourenço, Lees, Andrew, Svenningsson, P, Geshanthi Hondhamuni, Filipa Lourenço Almeida, John A. Hardy, Rickie Patani, Demis A. Kia, Siva, K, Alessandro Quattrone, Manzoni, Claudia, Paola Zuccotti, Rohan de Silva, Simone, Roberto, Virdi, GS, Zuccotti, P, Zareba-Paslawska, J, Kavitha Siva, Javad, F, Jasmine Harley, Jernej Ule, Siva, Kavitha, Patani, R, Warner, TT, Lees, A, Denti, MA, Simone, R, Hondhamuni, G, Daniah Trabzuni, Pittman, A, Justyna Zareba-Paslawska, Plagnol, V, Warner, Thomas T., Thomas T. Warner, Claudia Manzoni, Denti, Michela A., Faiza Javad, Virdi, Gurvir S., Harley, J, Selina Wray, Emmett, W, Mitchell, Jamie S., Gurvir S. Virdi, Ule, Jernej, Jamie S. Mitchell, De Silva, R, Victoria A. Kay, Andrew Lees, Kay, VA, Per Svenningsson, Almeida, FL, de Silva, Rohan, Hardy, John A., Oscar G. Wilkins, Pittman, Alan, Barahona-Torres, Natalia, Angelika Modelska, Ryten, M, Modelska, Angelika, Ferrari, R, Quattrone, Alessandro +101 morecore +1 more sourceThe novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]
, 2013 Frontotemporal lobar degeneration (FTLD) is the one of the most frequent neurodegenerative disorders characterized by behavioral and executive impairment, language disorders and motor dysfunction.Holton, Janice L., Tammaryn Lashley, Treacy, Rebecca, Laura Calo, Michel Goedert, Parmar, Malin,, Muqit, Miratul M. K., Janice L. Holton, Revesz, Tamas, Lashley, Tammaryn, Mariangela Iovino, Tamas Revesz, Robert J. Swingler, Pfisterer, Ulrich, Swingler, Robert J., Malin Parmar, Maria Grazia Spillantini, Calo, Laura, Ulrich Pfisterer, Miratul M. K. Muqit, Parmar, Malin, Spillantini, Maria Grazia, Iovino, Mariangela, Pfisterer, Ulrich,, Lund University., Iovino, Mariaangela, Goedert, Michel, Rebecca Treacy +27 morecore +1 more sourceDissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. [PDF]
, 2010 We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS.R. A. Barker, Z. Su, Spencer, C.C.A., Pearson, Justin P., McCarthy, Mark I, Wellcome Trust Case Control Consortium 2, Sawcer, SJ, Craddock, Nicholas John, Markus, Hugh S, Viswanathan, Ananth C., L. Peltonen, Potter, S, Rautanen, A, Gray, E, Hardy, J., Donnelly, P., Casas, J.-P., V. Plagnol, Deloukas, P, CORVIN, AIDEN PETER, Langford, C., Sawcer, Stephen J, Peltonen, L, Jankowski, J., Palmer, Colin N. A., E. Bramon, Edkins, Sarah, M. I. McCarthy, Peltonen, L., null null, G. Band, Craddock, Nicholas, Hudson, Gavin, Gray, E., Palmer, CN, Morrison, KE, Su, Zhan, Evans, Jonathan, Corvin, A, Viswanathan, A.C., A. C. Viswanathan, Morrison, Karen, Mathew, Christopher G.; id_orcid, Palmer, Colin NA, Spencer, C. C., Donnelly, P, Evans, J, Morrison, K.E.; id_orcid, Hunt, S., Palmer, C.N.A., Wood, Nicholas W., Craddock, N, Brown, Martin A., Hunt, S, H. Blackburn, A. Strange, D. Burn, J. Evans, Corvin, A., P. Donnelly, Gardner, M, Chinnery, Patrick F., Palmer, C. N., Burn, D, A. J. Lees, Bramon, E, Potter, Simon, Pirinen, Matti, Trembath, Richard C, Plagnol, V., Hardy, John, McCarthy, M. I., J. P. Pearson, Morris, H. R., C. Freeman, Edkins, S., Clarke, Carl E, Blackburn, Hannah, Morris, H.R., Clarke, Carl; id_orcid, Plagnol, V, Trembath, RC, Bhatia, Kailash, Langford, C, Gardner, M., S. Edkins, Viswanathan, A. C., Peltonen, Leena, Burn, D., R. C. Trembath, Sawcer, Stephen J., K. Bhatia, C. Langford, McCarthy, MI, Spencer, Chris CA, Spencer, Chris, Strange, Amy, C. C. A. Spencer, Bellenguez, C., J. Jankowski, Freeman, C., Brown, M. A., Spencer, Chris C.A., Bhatia, K., Langford, Cordelia, Wood, NW, Barker, R. A., Freeman, Colin, Chinnery, PF, Hunt, Sarah, Clarke, Carl E., C. E. Clarke, Markus, HS, Lees, A. J., Spencer, Chris C. A., P. F. Chinnery, Gray, Emma, Chinnery, P. F., Morris, Huw R., H. R. Morris, Paisan-Ruiz, C., Clarke, C.E., McCarthy, Mark I., Brown, MA, Blackburn, H., Wood, N.W., Clarke, CE, Gardner, Michelle, Plagnol, Vincent, S. Potter, A. Rautanen, Wood, N. W., Pearson, JP, Hardy, J, Evans, J., Morrison, K. E., Morrison, Karen E., Mathew, CG, Donnelly, Peter, C. Paisan-Ruiz, Chinnery, P.F., Pirinen, M., Lees, A.J., A. Corvin, Mathew, Christopher G, Su, Z., Edkins, S, Craddock, N., Brown, Martin A, Morris, Huw Rees, Trembath, Richard C., Wood, Nicholas W, Pirinen, M, Viswanathan, Ananth C, Clarke, C. E., Burn, David, Barker, Roger A, Strange, A., Blackwell, JM, Casas, J. P., C. G. Mathew, Williams, Nigel W, Paisan-Ruiz, C, Lees, AJ, P. Deloukas, N. W. Williams, C. Bellenguez, UK Parkinson's Disease Consortium, Deloukas, P., Mathew, C. G., G. Hudson, Su, Z, Plomin, R., Spencer, Chris C A, N. W. Wood, Plomin, R, S. Hunt, Morris, Huw R, Casas, Juan-Pablo, Barker, Roger A., Barker, Roger, Brown, Matthew A, Casas, JP, Barker, R.A., Rautanen, Anna, Bramon, Elvira, Plomin, Robert, Jankowski, Janusz, Band, G., McCarthy, M.I., Freeman, C, M. A. Brown, Bhatia, K, Brown, M. A, Sawcer, S.J., J. M. Blackwell, H. S. Markus, M. Gardner, Lees, Andrew J, Morris, HR, Band, Gavin, Strange, A, Brown, Matthew A., Markus, H.S., Blackburn, H, Paisan-Ruiz, Coro, Rautanen, A., Williams, Nigel W., Williams, N.W., Pearson, Justin P, C. N. A. Palmer, Blackwell, J. M., Deloukas, Panos, Bellenguez, Celine, Williams, N. W., Morrison, K.E., S. J. Sawcer, Brown, M.A., Bramon, E., Trembath, R. C., Barker, RA, Spencer, CC, Blackwell, Jennie M, Chinnery, Patrick F, Blackwell, Jennie M., Hudson, G, Spencer, C. C. A., Markus, Hugh S., N. Craddock, Morrison, Karen E, Lees, Andrew J., Band, G, Palmer, Colin N A; id_orcid, Jankowski, J, Blackwell, J.M., K. E. Morrison, Hudson, G., E. Gray, Viswanathan, AC, Potter, S., Palmer, C. N. A., Mathew, C.G., Williams, NW, J.-P. Casas, Bellenguez, C, J. Hardy, Williams, Nigel Melville, Pearson, J.P., R. Plomin, Pearson, J. P., Corvin, Aiden, Sawcer, S. J., M. Pirinen, Trembath, R.C., Markus, H. S. +254 morecore +1 more sourceConserved gene signatures shared among MAPT mutations reveal defects in calcium signaling
Frontiers in Molecular Biosciences, 2023 Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic events that lead to disease and the degree to which they are common across MAPT Miguel A. Minaya, Sidhartha Mahali, Abhirami K. Iyer, Abdallah M. Eteleeb, Rita Martinez, Guangming Huang, John Budde, Sally Temple, Alissa L. Nana, William W. Seeley, Salvatore Spina, Lea T. Grinberg, Lea T. Grinberg, Oscar Harari, Oscar Harari, Oscar Harari, Celeste M. Karch, Celeste M. Karch, Celeste M. Karch +18 moredoaj +1 more sourceExperimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration
Journal of Experimental Pharmacology, 2021 Marcello Giunta,1 Eino Solje,2 Fabrizio Gardoni,3 Barbara Borroni,1 Alberto Benussi1 1Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; 2Institute of Clinical Medicine - Neurology, University of ...Giunta M, Solje E, Gardoni F, Borroni B, Benussi A +4 moredoaj Cancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response
Scientific Data, 2023 Tau (MAPT) is a microtubule-associated protein causing common neurodegenerative diseases or rare inherited frontotemporal lobar degenerations. Emerging evidence for non-canonical functions of Tau in DNA repair and P53 regulation suggests its involvement ...Maurizio Callari, Martina Sola, Claudia Magrin, Andrea Rinaldi, Marco Bolis, Paolo Paganetti, Luca Colnaghi, Stéphanie Papin +7 moredoaj +1 more sourceThe Effect of MAPT H1 and APOE ε4 on Transition from Mild Cognitive Impairment to Dementia [PDF]
, 2010 Microtubule-associated protein tau (MAPT) and apolipoprotein E (APOE) are involved in the pathogenic mechanisms of Alzheimer's disease (AD). We prospectively followed three longitudinal independent samples (total n=319) with amnestic mild cognitive ...Pastor, Pau, Barabash Bustelo, Ana, Cabranes Díaz, José Antonio, Marcos Dolado, Alberto, Samaranch, Lluis et al. +4 morecore +1 more source
