Results 71 to 80 of about 22,079 (225)

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

, 2018
Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate.
Senthilvelrajan Kaniyappan (3638545), Eckhard Mandelkow (267152), Balaji, V., Kaniyappan, S., Wang, Y., Eva-Maria Mandelkow (2415553), Varun Balaji (3638548), Mandelkow, E., Yipeng Wang (9800)   +8 more
core   +1 more source

No difference in mean middle cerebral artery blood velocity responses between lower‐ and upper‐body unilateral resistance exercise in untrained individuals

Experimental Physiology, EarlyView.
Abstract Dynamic resistance exercise (RE) produces sinusoidal fluctuations in blood pressure that are mirrored by middle cerebral artery blood velocity (MCAv). However, whether lower‐ or upper‐body RE elicits a differential cerebrovascular response has not yet been examined.
Stephanie Korad, Toby Mündel, Blake G. Perry   +2 more
wiley   +1 more source

Cure MAPT FTD: MAPT Families Fighting for a Future

Alzheimer's & Dementia
Abstract Background Frontotemporal dementia is the most common form of dementia impacting those under the age of 60. It is estimated that 30% of affected persons have a genetic predisposition to this disease, with mutations in the genes encoding progranulin (
openaire   +2 more sources

H1-MAPT and the Risk for Familial Essential Tremor

PLoS ONE, 2012
The most frequent MAPT H1 haplotype is associated with the risk for developing progressive supranuclear palsy and other neurodegenerative diseases such as Parkinson's disease. A recent report suggests that the MAPT H1 is associated with the risk for developing essential tremor. We wanted to confirm this association in a different population.
Elena García-Martín, Carmen Martínez, Hortensia Alonso-Navarro, Julián Benito-León, Oswaldo Lorenzo-Betancor, Pau Pastor, Tomás López-Alburquerque, Lluis Samaranch, Elena Lorenzo, José A G Agúndez, Félix Javier Jiménez-Jiménez   +10 more
openaire   +4 more sources

Microtubule Associated Protein-Tau (MAPT) Is Influenced by ER: ICI182,780, a Selective ER Inhibitor, Down-Regulates MAPT Expression and Reverses Resistance to Taxanes in MAPT- and ER-Positive Breast Cancer Cells.

, 2009
Background: Taxanes are important drugs in treatment of breast cancer. These drugs bind to tubulin and suppress spindle microtubule dynamics, which leads to cell cycle arrest in the G2/M phase followed by apoptosis.
H. Ikeda, T. Nogami, F. Hara, N. Taira, T. Shien, H. Doihara   +5 more
core   +1 more source

Thermoregulatory and plasma neurobiomarker responses to heat tolerance assessment in exertional heat illness and matched controls

Experimental Physiology, EarlyView.
Abstract Exercise in the heat and elevated tissue temperature are associated with neuronal stress and changes in blood–brain barrier (BBB) function. More severe thermal insult may manifest as exertional heat illness (EHI) and complication by central nervous system (CNS) dysfunction may persist post‐EHI.
Tom W. Palin, Jo Corbett, Lisa J. Hill, David R. Woods, Alex A. M. Gould, Barney Wainwright, James A. Roberts, Chloe N. Thomas, Daniel Snape, Carol House, Omar Tayari, Richard J. Elsworthy, James L. Mitchell, Andrew J. Roberts, John P. O'Hara, Michael J. Stacey   +15 more
wiley   +1 more source

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

Stem Cell Reports, 2018
Summary: Tauopathies such as frontotemporal dementia (FTD) remain incurable to date, partially due to the lack of translational in vitro disease models.
An Verheyen, Annick Diels, Joke Reumers, Kirsten Van Hoorde, Ilse Van den Wyngaert, Constantin van Outryve d’Ydewalle, An De Bondt, Jacobine Kuijlaars, Louis De Muynck, Ronald De Hoogt, Alexis Bretteville, Steffen Jaensch, Arjan Buist, Alfredo Cabrera-Socorro, Selina Wray, Andreas Ebneth, Peter Roevens, Ines Royaux, Pieter J. Peeters   +18 more
doaj   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Genetic analysis of MAPT haplotype diversity in frontotemporal dementia

, 2008
The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD).
Forstl, H., Laws, S.M., Eisele, T., Kurz, A., Friedrich, P., Diehl-Schmid, J., Bauml, J., Mueller, J., Ibach, B., Müller, J., Laws, S., Riemenschneider, M., Laws, SM;Friedrich, P;Diehl-Schmid, J;Muller, J;Ibach, B;Bäuml, J;Eisele, T;Förstl, H;Kurz, A;Riemenschneider, M   +12 more
core   +2 more sources

MAPT nonsynonymous variants and allele frequencies.

, 2016
MAPT nonsynonymous variants and allele frequencies.
Basar Bilgic (3122505), Peter Heutink (39587), Nihan Erginel-Unaltuna (3122523), Gamze Guven (3122517), Hasmet Hanagasi (3122508), Andrew Singleton (23294), J. Raphael Gibbs (66139), Jose Bras (376253), Rita Guerreiro (237387), Patrizia Rizzu (260324), John Hardy (23295), Walter Just (3122514), Hakan Gurvit (3122511), Ebba Lohmann (524849), Murat Emre (3122520)   +14 more
core   +1 more source