Results 81 to 90 of about 22,079 (225)

Translating the U.S. POINTER cognitive‐slope benefit into predicted clinical progression: an external‐cohort analysis with exploratory economic thresholds

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 4, December 2026.
Abstract INTRODUCTION Cognitive‐slope benefits from multidomain lifestyle trials are difficult to interpret clinically or economically. We translated the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) structured‐versus‐self‐guided cognitive‐slope benefit into predicted clinical progression and ...
Saki Nakashima, Kenichiro Sato, Yoshiki Niimi, Wataru Satake, Takeshi Iwatsubo, for the Alzheimer's Disease Neuroimaging Initiative   +5 more
wiley   +1 more source

Experimental modeling for tauopathies: An isogenic panel of humanized MAPT knock-in mice

Neuroscience Research
Tauopathies are a group of neurodegenerative diseases characterized by the aberrant accumulation of tau protein in the brain. While numerous mouse models have been developed to study tauopathies, the majority depend on tau overexpression, which may ...
Takahiro Morito, Naoto Watamura
doaj   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction We have conducted the pathological cohort study of autopsied cases of Hisayama residents to reveal a recent trend of dementia‐related pathology. We noticed a trend of putaminal involvement of Alzheimer's disease (AD) with parkinsonism. Then,
Hideomi Hamasaki, Hiroyuki Honda, Satoshi O. Suzuki, Masahiro Shijo, Tomoyuki Ohara, Yozo Hatabe, Tsuyoshi Okamoto, Toshiharu Ninomiya, Toru Iwaki   +8 more
doaj   +1 more source

4‐Methylumbelliferone Restores Age‐Related Changes in Perineuronal Nets, Memory, and Neuroinflammation

Glia, Volume 74, Issue 12, December 2026.
Brain aging alters perineuronal nets and neuroinflammation. 4‐methylumbelliferone reversed these aging‐associated changes. 4‐methylumbelliferone reduced age‐associated cognitive decline. Six months of chronic oral treatment was well tolerated. ABSTRACT Aging‐associated cognitive decline is closely linked to dysregulated glial activity and chronic ...
Anda Cimpean, Jana Mizerakova, Noelia Martinez‐Varea, Dana Marekova, Lucia Machova Urdzikova, James W. Fawcett, Pavla Jendelova, Jessica C. F. Kwok   +7 more
wiley   +1 more source

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease

Translational Neurodegeneration
Background Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer’s disease (AD). Tau pathology occurs in axons of affected neurons and tau removal from axons might thus be an early intervention ...
Abdolhossein Zare, Saeede Salehi, Jakob M. Bader, Anna-Lena Wiessler, Manuela Prokesch, Vincent Albrecht, Carmen Villmann, Matthias Mann, Michael Briese, Michael Sendtner   +9 more
doaj   +1 more source

Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For Tauopathies

Molecular Therapy: Nucleic Acids, 2014
In Alzheimer's disease, progressive supranuclear palsy, and a number of other neurodegenerative diseases, the microtubule associated protein tau aggregates to form intracellular neurofibrillary tangles and glial tangles, abnormal structures that are part
Reeteka Sud, Evan T Geller, Gerard D Schellenberg   +2 more
doaj   +1 more source

The Effect of MAPT H1 and APOE ε4 on Transition from Mild Cognitive Impairment to Dementia

, 2010
Microtubule-associated protein tau (MAPT) and apolipoprotein E (APOE) are involved in the pathogenic mechanisms of Alzheimer's disease (AD). We prospectively followed three longitudinal independent samples (total n=319) with amnestic mild cognitive ...
Pastor, Pau, Barabash Bustelo, Ana, Cabranes Díaz, José Antonio, Marcos Dolado, Alberto, Samaranch, Lluis et al.   +4 more
core   +1 more source

Inverse problems for semilinear elliptic PDE with a general nonlinearity a(x,u)$a(x,u)$

Transactions of the London Mathematical Society, Volume 13, Issue 1, December 2026.
Abstract This article studies the inverse problem of recovering a nonlinearity in an elliptic equation Δu+a(x,u)=0$\Delta u + a(x,u) = 0$ from boundary measurements of solutions. Previous results based on first‐order linearization achieve this under a sign condition on ∂ua(x,u)$\partial _u a(x,u)$, and results based on higher order linearization ...
David Johansson, Janne Nurminen, Mikko Salo   +2 more
wiley   +1 more source

MAPT promoter CpG island hypermethylation is associated with poor prognosis in patients with stage II colorectal cancer

Cancer Management and Research, 2019
Chuntao Wang,1 Yanliang Liu,1 Wenyi Guo,1 Xu Zhu,1 Nita Ahuja,2 Tao Fu11Department of Gastrointestinal Surgery II, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital, Wuhan University, Wuhan, People’s Republic of China ...
Wang C, Liu Y, Guo W, Zhu X, Ahuja N, Fu T   +5 more
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