Results 91 to 100 of about 20,159 (186)

A comprehensive analysis of MAPT-related genetic risk in Alzheimer’s disease

IBRO Neuroscience Reports
Despite some research into the correlation between microtubule associated protein tau (MAPT) rs2471738 and the risk of AD, the findings remain inconclusive.
Shitao Wang, Guoshuai Luo, Xiangqian Ding, Guangxin Sun, Mengen Zhang, Jingjing Dong, Hui Xu, Jinghong Lu, Zongyou Li, Bin Ning, Hongbo Liu   +10 more
doaj   +1 more source

Structural study of the microtubule-associated protein tau locus of Alzheimer's disease in Taiwan

Biomedical Journal, 2014
Background: Haplotype structure of the microtubule-associated protein tau (MAPT) gene is associated with various tauopathies in the Caucasian population.
Chun-Wei Chang, Wen-Chuin Hsu, Alan Pittman, Yih-Ru Wu, John Hardy, Hon-Chung Fung   +5 more
doaj   +1 more source

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) can be caused by autosomal‐dominant familial Alzheimer's disease (FAD) mutations in amyloid precursor protein (APP) or presenilin‐1 and 2, which form an enzyme substrate complex. KAT5 binds to the APP intracellular domain.
Greg A Cary, Jessica E. Young, Shannon E. Rose, Harald Frankowski, Heather Wilkins, Sai Sruthi Amirtha Ganesh, Julia Draper, Martin Darvas, Mark Bothwell, Suman Jayadev, Aquene N. Reid, Anna Greenwood, Allan I. Levey, Karina Leal, Gregory W. Carter, Jesse C. Wiley   +15 more
wiley   +1 more source

Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy [PDF]

, 2018
Deletion of Mapt, encoding the microtubuleâ binding protein Tau, prevents disease in multiple genetic models of hyperexcitability. To investigate whether the effect of Tau depletion is generalizable across multiple sodium channel geneâ linked models of
Holth, Jerrah K., Bunton‐stasyshyn, Rosie, Anumonwo, Charles K., Isom, Lori L., Noebels, Jeffrey L., Chen, Chunling, Meisler, Miriam H.   +6 more
core   +1 more source

Patient‐derived forebrain cortical organoids reveal biphasic tau–MAP6–microtubule axis dysfunction in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION In frontotemporal dementia (FTD), tau detaches from axonal microtubules and forms pathological aggregates. Rather than stabilizing microtubules, tau promotes labile microtubule domains, redefining its role in neurodegeneration and underscoring the need for human models that capture temporal disease progression.
Xiaohuan Sun, Skandha Ramakrishnan, Victor C. Ogbolu, Nicholas M. Kanaan, Celeste M. Karch, Peter W. Baas, Liang Qiang   +6 more
wiley   +1 more source

Elimination of tau tangles and soluble aggregates with the small molecule ACI‐16664 prevents neurodegeneration in vivo

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Nicolas Preitner, Véronique Dehlinger, Patrick Rodriguez, Kerstin Fabbri, Yvan Varisco, Matteo Pigni, Alessandra Lovison, Lucas Münzenmaier, Kasia Piorkowska, Aline Fuchs, Nadine Ait‐Bouziad, Nicolas Fournier, Sandra Jepaul, Jérôme Molette, Emanuele Gabellieri, Vincent Darmency, Sonia Poli, Andrea Pfeifer, Marie Kosco‐Vilbois, Francesca Capotosti   +19 more
wiley   +1 more source

Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations [PDF]

, 2018
Mutant Tau (MAPT) can lead to frontotemporal lobar degeneration (FTLD). Previous studies associated MAPT mutations and altered function with aneuploidy and chromosome instability in human lymphocytes and in Drosophila development. Here we examine whether
Heidi J. Chial, Julbert Caneus, Dennis W. Dickson, Christina M. Coughlan, Antoneta Granic, Rosa Rademakers, Huntington Potter   +6 more
core   +1 more source

Neuropathology‐specific language features in primary progressive aphasia

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Primary Progressive Aphasia (PPA) clinical syndromes do not align consistently with underlying pathology. This study aimed to identify language markers for specific neuropathologies using both standard clinical tests and narrative speech analysis.
Jane Stocks, Elena Barbieri, Michelle Anne Los, Cynthia K. Thompson, Tamar Gefen, Changiz Geula, M.‐Marsel Mesulam, Sandra Weintraub   +7 more
wiley   +1 more source

MAPT rs242562 and GSK3B rs334558 are associated with Parkinson’s Disease in central China [PDF]

, 2014
Background: Microtubule-associated protein tau (MAPT) is a neuronal protein involved in the pathogenesis of several neurodegenerative diseases including Parkinson’s Disease (PD).
Long, Xi, Xiong, Jing, Desheng Zhai, Wang, Youpei, Nian Xiong, Wang, Tao, Zhai, Desheng, Ping Wu, Ying Zhao, Huang, Jinsha, Ling Liu, Zhentao Zhang, Zhicheng Lin, Zhao, Ying, Zhang, Zhentao, Liu, Ling, Yu, Lan, Dingan Wang, Guo, Kexin, Wu, Jing, Jing Wu, Xi Long, Lin, Zhicheng, Tao Wang, Jinsha Huang, Wu, Ping, Xiong, Nian, Lan Yu, Wang, Dingan, Jing Xiong, Youpei Wang, Kexin Guo   +31 more
core   +1 more source

Acute viral encephalitis impacts dense‐core amyloid plaque pathology and dysregulates myeloid responses to amyloid plaques

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Recent epidemiological datasets have associated viral encephalitis exposure (i.e., viral‐induced neuroinflammation) with increased risk of Alzheimer's disease (AD) and dementia, highlighting the need to uncover how it may impact AD neuropathology.
Dominic Ibarra Javonillo, Susana Furman, Lucas Le, Kellie Fernandez, Jazmyn Mulford, Vidushi Singla, Roshni Jha, Kate Inman Tsourmas, Nellie E. Kwang, Kim N. Green, Thomas E. Lane   +10 more
wiley   +1 more source